2-Bromo-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)-pyridine

2 - Bromo - 4 - (3 - pyridin - 2 - yl - 1H - pyrazol - 4 - yl) - pyridine is an organic compound with a wide range of uses. In the field of organic synthesis, this compound is often used as a key intermediate. Because its structure is rich in pyridine and pyrazole groups, giving it unique reactivity and selectivity, chemists can modify and derive its structure through delicate chemical reactions, and then construct organic molecules with more complex structures and more specific functions. This is of great significance in the field of medicinal chemistry. In the design and synthesis of many drug molecules, these compounds are often used as starting materials. By introducing different functional groups, the physicochemical properties, biological activities and pharmacokinetic properties of the molecules are optimized, in order to develop innovative drugs with better curative effect and less side effects.
In the field of materials science, 2 - Bromo - 4 - (3 - pyridin - 2 - yl - 1H - pyrazol - 4 - yl) - pyridine also shows potential application value. Because of its specific electronic structure and molecular configuration, it may participate in the preparation of materials with special photoelectric properties. For example, it may be used to synthesize organic semiconductor materials, which play a central role in devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells, and are expected to improve the performance and efficiency of the devices.
In addition, in the field of coordination chemistry, the nitrogen atom in the compound can act as a check point to coordinate with metal ions to form metal complexes. These metal complexes often have unique structures and properties and have potential applications in catalysis, fluorescence sensing, etc. For example, some metal complexes can act as efficient catalysts to accelerate the progress of specific chemical reactions, exhibiting good catalytic activity and selectivity.

To prepare 2-bromo-4- (3-pyridine-2-yl-1H-pyrazole-4-yl) -pyridine, the method is as follows.
First, the corresponding precursor containing pyridine and pyrazole structures can be started. First, take a suitable pyridine derivative and make it condensate with the pyrazole derivative under specific conditions. Choose a suitable solvent, such as dichloromethane, N, N-dimethylformamide, etc., and add a suitable base, such as potassium carbonate, triethylamine, etc., to this solvent system to promote the reaction to occur. The reaction temperature needs to be finely regulated, or between room temperature and moderate heating range, such as 30-80 ° C, after a certain period of reaction, the two are initially combined.
Subsequently, the preliminary product is brominated. A brominating reagent, such as N-bromosuccinimide (NBS), benzoyl peroxide, etc. can be used as an initiator, under the protection of inert gas, in a suitable solvent such as carbon tetrachloride. Temperature control is also critical, or maintained at 40-60 ° C, so that the bromine atom precisely replaces the hydrogen atom at the target position, thereby obtaining 2-bromo-4- (3-pyridine-2-yl-1H-pyrazole-4-yl) -pyridine.
Second, the strategy of synchronizing the construction of the pyridine ring with the pyrazole ring can also be started. Specific nitrogen-containing and carbon-containing raw materials, such as compounds containing amino and carbonyl groups, are prepared by multi-step cyclization reaction. First, the raw material is cyclized in the molecule under the catalysis of acid or base, and the structure of the pyrazole ring is constructed, and the activity check point connected to the pyridine ring is reserved. After subsequent reactions, the pyridine ring is constructed under suitable conditions, and bromine atoms are introduced. During the reaction process, factors such as solvent selection, catalyst dosage, reaction time and temperature need to be carefully considered and optimized to effectively improve the yield and purity of the product, and finally obtain 2-bromo-4- (3-pyridine-2-yl-1H-pyrazole-4-yl) -pyridine.

2 - Bromo - 4 - (3 - pyridin - 2 - yl - 1H - pyrazol - 4 - yl) - pyridine is an organic compound. Its physical and chemical properties are quite critical and of great significance in scientific research and related fields.
First of all, the appearance of this compound is usually in solid form, and the specific color may vary due to purity and crystal form. It is usually white to light yellow solid powder, like fine sand and dust, with uniform texture. The melting point of 2-Bromo-4- (3-pyridin-2-yl-1H-pyrazol-4-yl) -pyridine is one of the important physical properties of the substance. The melting point of 2-Bromo-4- (3-pyridin-2-yl-1H-pyrazol-4-yl) -pyridine is in a specific temperature range, but the exact value varies depending on the measurement method and conditions. Generally speaking, its high melting point indicates that the intermolecular force is strong and the structure is relatively stable, just like a closely connected masonry, forming a stable structure.
In terms of solubility, the compounds have different solubility in common organic solvents. In polar organic solvents, such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it has good solubility, just like being integrated into water droplets of Wangyang, and can disperse quickly; in non-polar organic solvents, such as n-hexane and petroleum ether, the solubility is poor, and it is difficult to blend like oil and water.
From the perspective of chemical properties, the bromine atom in the molecule has high reactivity and can participate in many substitution reactions, just like an active dancer, which is easy to interact with other molecules. The nitrogen atom on the pyridine and pyrazole ring is rich in electrons and can participate in the coordination reaction as an electron donor, forming complexes with metal ions, etc., like dancing hand in hand with partners to build new chemical systems. The chemical stability of this compound is acceptable, but under specific conditions, such as strong acid, strong base or high temperature environment, the molecular structure may change, just like a fragile building block, recombined under external force. These physicochemical properties lay the foundation for its application in organic synthesis, medicinal chemistry and other fields.

I don't know the price of 2 - Bromo - 4 - (3 - pyridin - 2 - yl - 1H - pyrazol - 4 - yl) - pyridine in the market. This is a fine chemical, and its price is easily influenced by many factors.
First, the cost of preparing this compound is the key factor. The price of raw materials, the complexity of synthesis steps, and the difficulty of reaction conditions are all related to the preparation cost. If raw materials are rare and difficult to find, and the synthesis requires multiple complex reactions, the cost will be high, and the price will also rise.
Second, the market supply and demand situation has a great impact. If the demand for this product is strong and the supply is limited, the merchant may raise the price due to the tight market; conversely, if the supply exceeds the demand, the price may be reduced for promotional sales.
Third, product purity is also an important consideration. High-purity products are difficult to prepare and have strict technical and process requirements, and the price is naturally higher than that of low-purity products.
Fourth, manufacturers and brands can also control the price. Well-known large factories pay attention to quality control and R & D investment, and the product quality is excellent, and the price may be slightly higher; new factories or small factories compete for market share, and the price may be more affordable.
In addition, regional differences, transportation costs, macroeconomic conditions, etc., will also have a greater or lesser impact on their prices. Therefore, in order to know the exact price, it is necessary to consult the relevant chemical product suppliers in detail and comprehensively consider various factors in order to obtain more accurate price information.

2 - Bromo - 4 - (3 - pyridin - 2 - yl - 1H - pyrazol - 4 - yl) - pyridine is an organic compound, and its stability is related to many aspects.
In this compound, the bromine atom is connected to the pyridine and pyrazole groups. From a chemical bond point of view, the carbon-bromine bond has a certain polarity, but its bond energy is not very high, and under certain conditions, it may break. When encountering nucleophiles, the bromine atom is easily replaced, resulting in molecular structure changes and impaired stability.
In addition, the pyridine and pyrazole groups both contain nitrogen atoms and have certain alkalinity. In an acidic environment, nitrogen atoms may protonate, which not only changes the molecular charge distribution, but also affects the intermolecular forces, which in turn affects its stability. For example, after protonation, the polarity of the molecule increases, and the solubility decreases in non-polar solvents, which may lead to aggregation or precipitation, which affects its stability.
At the same time, the conjugate system has a great impact on the stability of the compound. The conjugate system formed by pyridine and pyrazole can delocalize electrons, reduce molecular energy, and improve stability. However, if other groups are introduced into the system or chemical reactions occur, the stability of the conjugate system will also decrease.
External conditions such as light and heating also have a significant impact on its stability. Under light, the molecule or absorbs photon energy and transitions to an excited state, causing the chemical reaction activity to increase, triggering reactions such as photolysis. When heated, the thermal motion of the molecule intensifies. When the energy reaches the threshold of chemical bond breaking, the compound decomposes and loses stability.
In addition, the presence of impurities may also affect its stability. Certain impurities may act as catalysts to accelerate the decomposition of compounds or other chemical reactions.
Overall, the stability of 2-Bromo-4- (3-pyridin-2-yl-1H-pyrazol-4-yl) -pyridine is restricted by many factors such as internal structure and external conditions. When storing and using, these factors need to be fully considered to ensure its stability.