2-BROMO-3-NITRO-4-METHYL-5-FLUOROPYRIDINE

2-Bromo-3-nitro-4-methyl-5-fluoropyridine is a key compound in organic synthesis. It has a wide range of uses and is often used as an intermediate in the synthesis of drugs in the field of medicinal chemistry. Due to its unique structure, different functional groups can be introduced through various chemical reactions to construct drug molecules with specific biological activities.
In the field of pesticide synthesis, it also plays an important role. It can be chemically modified to create new pesticides with efficient pest control effect and low impact on the environment, which is in line with the current trend of green pesticide development.
Furthermore, in the field of materials science, this compound may participate in the synthesis of materials with special properties. For example, by polymerizing with other monomers, the material is endowed with unique electrical, optical or thermal properties, which are used in electronic devices, optical materials and many other aspects.
In addition, in the study of organic synthesis methodologies, 2-bromo-3-nitro-4-methyl-5-fluoropyridine can be used as a model substrate to explore new reaction pathways and reaction mechanisms, and to promote the development of organic chemistry. The diverse functional groups in its structure provide rich possibilities for various chemical reactions, allowing chemists to deeply explore the reaction behavior under different reaction conditions, and then develop more efficient and green organic synthesis methods.

2-Bromo-3-nitro-4-methyl-5-fluoropyridine is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
In terms of its appearance, under room temperature and pressure, it is often in a solid state, mostly powdery or crystalline, and the color may vary from white to light yellow. This color state can vary depending on the purity and preparation method.
Melting point is one of its key physical properties. After many experiments, it is about a certain temperature range, but the exact value varies slightly due to different literature and experimental conditions. When heated to this temperature, the compound gradually melts from a solid state to a liquid state. This phase transition process has a great impact on its application in synthesis reactions and material preparation.
The boiling point cannot be ignored either. In an atmospheric pressure environment, when a specific high temperature is reached, the compound changes from a liquid state to a gas state. The value of the boiling point reflects the strength of the intermolecular forces, which is of great significance for the distillation operation of separating and purifying the compound.
In terms of solubility, it varies in common organic solvents. In some polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), there is a certain solubility, which makes it useful as a reactant or intermediate in chemical reactions using such solvents as media. In non-polar organic solvents, such as n-hexane and cyclohexane, the solubility is very small. In water, due to the difference in molecular polarity and water, the solubility is also low.
The density is the mass per unit volume, which characterizes the compactness of the substance. The density value of this compound, compared with other similar structural compounds, has a specific value and has a significant impact in the process involving mixed systems and phase separation.
In addition, the stability of this compound also belongs to the category of physical properties. Under general environmental conditions, it still has a certain stability. When exposed to high temperature, strong light or specific chemical reagents, decomposition or chemical reactions may occur, resulting in changes in its structure and properties.
In summary, the physical properties of 2-bromo-3-nitro-4-methyl-5-fluoropyridine, such as appearance, melting point, boiling point, solubility, density and stability, play a decisive role in its application in many fields such as organic synthesis, pharmaceutical chemistry, and materials science.

The method of preparing 2-bromo-3-nitro-4-methyl-5-fluoropyridine often takes the compound containing the pyridine structure as the starting material. One method is to select an appropriate methyl pyridine derivative, first treat it with a fluorine-substituted reagent, and introduce fluorine atoms. Fluorinated reagents commonly used, such as Selectfluor, etc., under suitable reaction conditions, such as a specific solvent (such as acetonitrile, etc.), appropriate temperature and the presence of a base, the specific position of the methyl pyridine derivative can be fluorinated to obtain a fluorine-containing pyridine intermediate.
Then, bromide is applied to this intermediate. Brominated reagents can be selected from liquid bromine, N-bromosuccinimide (NBS), etc. If NBS is used, an initiator (such as benzoyl peroxide, etc.) is often required. Under heating or lighting conditions, in a suitable solvent (such as carbon tetrachloride, etc.), the bromine atom is replaced at a specific position in the pyridine ring to obtain a pyridine intermediate containing bromine and fluorine.
Finally, nitrification is carried out. The commonly used nitrification reagent is a mixed acid of concentrated nitric acid and concentrated sulfuric acid. The above intermediates are slowly added to the mixed acid at low temperature (such as 0-5 ° C), so that the pyridine ring is introduced into the nitro group, and the final product is 2-bromo-3-nitro-4-methyl-5-fluoropyridine. During the reaction process, attention should be paid to the precise control of the reaction conditions at each step to improve the yield and purity of the product, and the reaction waste should be properly disposed of to meet the requirements of environmental protection.

2-Bromo-3-nitro-4-methyl-5-fluoropyridine is a chemical substance. During storage, the following things should be noted:
First, it must be placed in a dry place. If this substance encounters water vapor, it may cause reactions such as hydrolysis and cause it to deteriorate. Because water can interact with some active groups and destroy the molecular structure. If in a humid environment, bromine atoms, nitro groups, etc. may be affected, causing chemical properties to change.
Second, it should be stored in a cool place, away from heat sources and open flames. When this compound is heated, it may become unstable, and even risk decomposition, combustion and even explosion. Nitro is easily decomposed when heated, releasing a lot of energy. If it is in a high temperature environment, it may cause danger.
Third, care should be taken to avoid co-storage with oxidizing and reducing substances. The nitro group in its structure is oxidizing, while the bromine atom may be reducing under specific conditions, encountering strong oxidizing or strong reducing substances, or react violently. For example, in contact with strong reducing agents, the nitro group may be reduced, and the bromine atom may be replaced, changing its chemical composition and properties.
Fourth, the storage container must be well sealed. Prevent air from entering, so as not to react with oxygen, carbon dioxide and other components in the air. Oxygen may cause oxidation, and carbon dioxide dissolves in water to form carbonic acid, or affect it.
Fifth, it should be placed in a place beyond the reach of children, and the corresponding warning signs should be made. Because it is a chemical substance, or toxic, corrosive and other hazards, if inadvertently exposed, it may cause harm to the human body. If it comes into contact with the skin, it may cause burns; inhalation or ingestion, or damage health.
When storing 2-bromo-3-nitro-4-methyl-5-fluoropyridine, it should be stored in a dry, cool, non-oxidizing and reducing substances and well-sealed environment, and safety protection and warnings should be taken to ensure its stability and safety.

2-Bromo-3-nitro-4-methyl-5-fluoropyridine, the market price range of this substance is difficult to determine exactly. Due to the price of chemical reagents, it is often affected by many factors.
First, the difference between manufacturers has a great impact. Well-known large factories have high prices due to their sophisticated production processes and high product purity; while some small factories have relatively low prices in order to compete for the market.
Second, the number of purchases is also the key. If the batch is large, the manufacturer may give preferential discounts, and the unit price will drop; if you buy a small amount, the unit price will be higher.
Third, the relationship between market supply and demand affects price fluctuations. If the demand is strong and the supply is tight, the price will rise; on the contrary, the supply exceeds the demand, and the price may decline.
Fourth, the product purity requirements are different, and the price is also different. For high purity, the production is difficult, the cost is high, and the price is naturally high; for low purity, the price may be lower.
According to past market conditions, if this compound is of ordinary purity and purchased in small quantities, the price per gram may be between tens of yuan and hundreds of yuan; if purchased in large quantities and the purity requirements are not very high, the price per gram may drop to a few to tens of yuan. However, this is only a rough guess, and the actual price needs to be determined by consulting each supplier in detail.