2-bromo-3-iodopyridine

2-Bromo-3-iodopyridine is an organic compound with unique chemical properties.
In terms of reactivity, both bromine (Br) and iodine (I) are halogen atoms, so this compound has the characteristics of halogenated aromatics. In the nucleophilic substitution reaction, the halogen atom can be replaced by the nucleophilic reagent. Since the iodine atom has a slightly stronger ability to leave than the bromine atom, under suitable conditions, the iodine atom is more likely to be attacked and left by the nucleophilic reagent, and the nucleophilic substitution reaction occurs to generate new organic compounds.
In addition, the pyridine ring in 2-bromo-3-iodopyridine is aromatic and can participate in some reactions related to the aromatic ring. For example, in the presence of a specific catalyst, a Friedel-Crafts reaction can be carried out to introduce alkyl or acyl groups into the pyridine ring. At the same time, the lone pair electrons on the nitrogen atom of the pyridine ring make it basic to a certain extent, which can react with acids to form salts.
Furthermore, this compound is active in metal-catalyzed coupling reactions. Palladium-catalyzed cross-coupling reactions can react with reagents such as borate esters or halogenated hydrocarbons to form carbon-carbon bonds and realize the functionalization of molecules, which is used in the field of organic synthesis to construct more complex organic molecular structures. In conclusion, 2-bromo-3-iodopyridine has a variety of chemical reactivity due to the presence of halogen atom and pyridine ring, and has important applications in organic synthesis chemistry.

2-Bromo-3-iodopyridine is a key intermediate in the field of organic synthesis. The common synthesis methods are as follows:
One is halogenation. Pyridine is used as the starting material to achieve the goal through halogenation. Under specific reaction conditions, pyridine first interacts with brominating reagents (such as liquid bromine, N-bromosuccinimide, etc.) to generate 2-bromo pyridine. This process requires attention to the reaction temperature, the choice and dosage of catalysts. If the temperature is too high or the catalyst is too high, it is easy to cause the formation of polybrominated products. Then, 2-bromopyridine is reacted with iodizing reagents (such as potassium iodide, iodine elemental substance, etc.) to obtain 2-bromopyridine. In this step, factors such as the polarity of the reaction solvent and the reaction time have a significant impact on the reaction yield.
Second, metal-catalyzed cross-coupling method. Using 2-bromopyridine as a substrate, in the presence of metal catalysts (such as palladium catalysts), ligands (such as phosphine ligands) and bases, the cross-coupling reaction is carried out with iodine substitutes. The key to this method lies in the screening of metal catalysts and ligands. Different combinations have significant effects on reaction activity and selectivity. At the same time, the anhydrous and oxygen-free conditions of the reaction system are also crucial. A little carelessness will cause the catalyst to deactivate and then affect the reaction process.
Third, the guide group auxiliary method. Introduce a guide group on the pyridine ring, which can selectively guide the halogen atom into a specific position. Common guide groups such as amino, methoxy, etc. Let the pyridine derivative containing the guide group react with the brominating reagent first, and then react with the iodizing reagent. After the halogenation reaction is completed, the guide group is removed under suitable conditions to obtain 2-bromo-3-iodopyridine. The advantage of this method is that the halogenation position is highly selective, but the introduction and removal steps of guide groups are relatively cumbersome, and the reaction conditions need to be carefully controlled.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, purity and yield of target products and many other factors to choose the most suitable synthesis path.

2-Bromo-3-iodopyridine is an organic compound with important applications in many fields.
In the field of medicinal chemistry, it is often a key intermediate in the synthesis of drugs. Due to its unique chemical structure, it can introduce different functional groups through chemical reactions to build complex drug molecular structures. In the development of many antibacterial, antiviral and antitumor drugs, 2-bromo-3-iodopyridine plays an important role in assisting chemists in synthesizing compounds with specific biological activities, providing new possibilities for disease treatment.
In the field of materials science, this compound can participate in the preparation of special performance materials. By reacting with other monomers or compounds to form polymers or composites, the material is given unique electrical, optical or thermal properties. For example, it is used to prepare organic Light Emitting Diode (OLED) materials to improve their luminous efficiency and stability, so that display devices have better display effects.
In the field of organic synthetic chemistry, 2-bromo-3-iodopyridine is an important raw material and participates in many organic reactions, such as coupling reactions. Under the catalysis of transition metals, it is coupled with nucleophiles containing carbon, nitrogen, oxygen, etc., to form carbon-carbon, carbon-heteroatom bonds, to achieve efficient synthesis of complex organic molecules, to help chemists synthesize organic compounds with novel structures, and to expand the boundaries of organic synthesis chemistry.
In summary, 2-bromo-3-iodopyridine is widely used in the fields of medicine, materials and organic synthesis, which is of great significance to promote the development of related fields.

2-Bromo-3-iodopyridine is an organic compound with specific physical properties. It is mostly solid at room temperature and is caused by intermolecular forces. Looking at its melting point, it is about 90-92 ° C. This property is of great significance for the identification and purification of compounds. When heated to the melting point, solid can be turned into liquid, the molecule is energized, the movement intensifies, and the lattice structure is broken.
The boiling point of this compound is quite high, about 273-275 ° C. The high boiling point is due to the fact that the molecule contains heavy atoms such as bromine and iodine, which increases the intermolecular van der Waals force and requires more energy for gasification. This property can be separated by distillation according to the difference in boiling points when separating and purifying the compound.
In terms of solubility, 2-bromo-3-iodopyridine has good solubility in organic solvents such as dichloromethane, chloroform, and tetrahydrofuran. Due to the principle of "similar miscibility", the molecule of the compound has a certain non-polarity and is similar to the polarity of organic solvents. However, the solubility in water is poor. Water is a strong polar solvent, and the molecular force between the compound and the compound is weak, and it is difficult to miscible.
In addition, its appearance is often off-white to light yellow crystalline powder, which can help preliminary identification. And it has a certain stability. However, when it encounters specific chemical substances such as strong oxidants and strong bases, or under conditions such as high temperature and light, or chemically reacts, the stability is broken. This physical property provides an important basis for its synthesis, storage, and application.

The 2-bromo-3-iodopyridine is one of the organic compounds. It is not easy to know its market price. The price of this compound often changes with time, place, and supply and demand.
Looking at the past market conditions, the price of this compound may vary depending on the difficulty of production and the price of raw materials. If the production technique is simple and easy, and the raw materials are abundant and cheap, the price may be slightly lower; conversely, if the production process is complicated and the raw materials are thin and expensive, the price will be higher.
Furthermore, the supply and demand situation has a huge impact on its price. If there are many people in the market, but there are few people in supply, the price will rise; if the supply exceeds the demand, the price will be depressed.
In addition, prices vary in different places. Prosperous cities, where commerce gathers, or because of the convenience of logistics and information, their prices may be different from remote places.
However, today, I do not have the exact market price data, and it is difficult to say what the price is. To know the exact price, it is necessary to carefully observe the dynamics of the chemical raw material market, visit chemical product suppliers, or get a summary of their recent prices.