2-Bromo-3-fluoro-4-(trifluoromethyl)pyridine

2-Bromo-3-fluoro-4- (trifluoromethyl) pyridine is a crucial compound in the field of organic synthesis. It has a wide range of main uses and is often used as a key intermediate in the field of medicinal chemistry to create various specific drugs. The unique properties of the gainpyridine ring structure and halogen atom and trifluoromethyl can effectively regulate the activity, lipophilicity and metabolic stability of drug molecules. For example, when developing antibacterial drugs, it can precisely act on specific bacterial targets and demonstrate excellent antibacterial efficacy.
In the field of pesticide chemistry, 2-bromo-3-fluoro-4 - (trifluoromethyl) pyridine also plays a key role. With its own structural characteristics, pesticide molecules with high-efficiency insecticidal, bactericidal or herbicidal activities can be constructed. Such pesticides are often highly selective to target organisms, which can not only effectively prevent and control pests, but also reduce the adverse effects on non-target organisms and the environment, meeting the needs of the development of modern green pesticides.
Furthermore, in the field of materials science, this compound can be used to prepare functional materials. After rational chemical modification and polymerization, materials with unique photoelectric properties can be obtained. They have emerged in cutting-edge fields such as organic Light Emitting Diode (OLED) and solar cells, contributing to the progress of materials science. Overall, 2-bromo-3-fluoro-4- (trifluoromethyl) pyridine plays an indispensable role in many important fields, and is of great significance for promoting technological innovation and development in related fields.

The synthesis method of 2-bromo-3-fluoro-4- (trifluoromethyl) pyridine depends on the clever technology of organic synthesis. There may be many methods, and the following are the common numbers.
First, it can be started by pyridine derivatives, and bromine and fluorine atoms can be introduced by halogenation reaction. First select an appropriate pyridine substrate, use a specific halogenated reagent, and under suitable reaction conditions, let the bromine atom replace the hydrogen at a specific position, and then introduce the fluorine atom by a similar method. In this process, the control of the reaction conditions is the key. Factors such as temperature, solvent, catalyst, etc. need to be precisely regulated in order to make the reaction proceed in the expected direction and obtain a product with high yield and high selectivity.
Second, it can be achieved by the strategy of constructing a pyridine ring. Using raw materials containing corresponding substituents, pyridine rings are constructed by cyclization. For example, using small molecules containing bromine, fluorine and trifluoromethyl, through multi-step reactions, key intermediates are formed first, and then cyclized and condensed to obtain the target pyridine compound. This approach requires careful design of the reaction route, consideration of the feasibility and sequence of each step of the reaction, to ensure that each step can be carried out smoothly, and the product is easy to isolate and purify.
Furthermore, the reaction catalyzed by transition metals can also be a good method for synthesis. With the unique activity of transition metal catalysts, the selective construction of carbon-halogen bonds and carbon-carbon bonds can be achieved. For example, palladium-catalyzed cross-coupling reactions can cleverly connect fragments of different functionalizations to accurately synthesize target molecules. This method requires screening suitable transition metal catalysts, ligands and reaction conditions to improve reaction efficiency and selectivity.
All these synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh the availability of raw materials, cost, reaction difficulty and product purity, and make careful choices to achieve the purpose of synthesis.

2-Bromo-3-fluoro-4- (trifluoromethyl) pyridine, this is an organic compound. Looking at its physical properties, it is mostly liquid at room temperature and pressure, or a solid with a low melting point. Due to the difference in the intermolecular forces between the pyridine derivatives containing halogen atoms and fluoromethyl groups. Its boiling point is relatively high due to the presence of many halogen atoms and fluorine-containing groups in the molecule. Both halogen atoms and fluoromethyl groups have high electronegativity, which increases the intermolecular forces. To make the molecule break free from the liquid phase and transform into the gas phase, more energy is required, so the boiling point increases.
Its melting point is also affected by the molecular structure. The symmetry and regularity of the molecule affect the tightness of the lattice arrangement, and then the melting point. In the molecular structure of this compound, the spatial distribution of halogen atoms and fluoromethyl groups makes the molecular symmetry poor, the lattice arrangement is not extremely tight, and the melting point is not very high.
In terms of solubility, because it is an organic compound, it should have good solubility in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc. Due to the principle of "similar miscibility", the compound and organic solvents have certain organic properties, and the intermolecular forces can match each other. However, its solubility in water may not be good, because although there are nitrogen atoms in the molecule, the hydrophobicity of halogen atoms and fluoromethyl groups is strong, and it is difficult to form an effective force between water molecules and the compound molecules, making it difficult to dissolve in water.
In appearance, pure 2-bromo-3-fluoro-4- (trifluoromethyl) pyridine, or colorless to light yellow liquid or solid, depending on the purity and environmental conditions. If it contains impurities, the appearance or color and state will change. And the compound is volatile, and in an open environment, some molecules can escape from the liquid phase to the gas phase.

2-Bromo-3-fluoro-4- (trifluoromethyl) pyridine, this is an organic compound. Its chemical properties are particularly important and of great significance in the field of organic synthesis.
Let's talk about its halogen atom properties first. The molecule contains bromine atoms and fluorine atoms, and the bromine atom has good activity and can often participate in nucleophilic substitution reactions. In many organic reactions, nucleophilic reagents are prone to attack the carbon atom connected to the bromine atom, and the bromine ion leaves, thereby forming new organic compounds. For example, in alkaline environments, hydroxyl groups and other nucleophiles can replace bromine atoms to obtain hydroxyl-containing pyridine derivatives. Fluorine atoms have a significant impact on the distribution of molecular electron clouds due to their extremely high electronegativity, causing molecular polarity changes and enhancing molecular stability. The density of their ortho and para-site electron clouds decreases, making electrophilic substitution reactions more difficult.
Furthermore, the existence of trifluoromethyl also greatly affects molecular properties. Trifluoromethyl is a strong electron-absorbing group, which can greatly reduce the electron cloud density of the pyridine ring, making it more difficult for electrophilic substitution reactions on the pyridine ring to occur, but making nucleophilic substitution reactions easier. At the same time, trifluoromethyl can enhance molecular fat solubility and play a significant role in the pharmacokinetic properties of the compound in vivo, such as absorption and distribution.
In addition, the pyridine ring of this compound has aromatic properties and can carry out some reactions related to aromatic rings. The nitrogen atom of pyridine has a certain alkalinity and can react with acids to form salts. This property has applications in separation, purification and pharmaceutical preparations.
Overall, 2-bromo-3-fluoro-4 - (trifluoromethyl) pyridine contains special functional groups and has rich chemical properties. It has broad application prospects in many fields such as organic synthesis and medicinal chemistry.

The price of 2 - Bromo - 3 - fluoro - 4 - (trifluoromethyl) pyridine has been confirmed in Wuwei City. However, the price of such compounds often varies due to multiple reasons.
Its purity is one of the main reasons. If the purity is high and there are few impurities, it is suitable for high-demand fields such as fine chemicals and pharmaceuticals, and the price must be high; if the purity is low, it is only used for general experiments or industrial primary processes, and the price is relatively low.
Mass production scale also has an impact. Mass production, due to economies of scale, unit cost may decrease, and the price will also decrease; if only a small amount of customization is made, the cost of production preparation, equipment commissioning, etc. is spread over a small amount of products, and the price will increase.
Furthermore, the cost of raw materials is related. If the raw materials for synthesizing this compound are easy to obtain and inexpensive, the price can also be controlled; if the raw materials are rare or difficult to prepare, the cost will increase greatly, and the price will be high.
The trend of supply and demand also affects its price. If the demand is strong and the supply is small, the price will rise; if the market is saturated, the supply is large and the demand is small, the price may drop.
In addition, different suppliers have different pricing strategies, or due to brand, service, after-sales and other factors, the price varies.
To know the actual price, you can consult chemical raw material suppliers, chemical trading platforms, or ask colleagues at relevant industry conferences and forums to obtain a more accurate price range.