2-bromo-3-fluoro-4-methyl-pyridine

2-Bromo-3-fluoro-4-methylpyridine is a class of organic compounds with a wide range of uses and important value in many fields.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of various drugs. Due to its unique chemical structure, specific functional groups can be added or transformed by organic synthesis, and then molecular structures with specific pharmacological activities can be constructed. On this basis, drugs for specific diseases can be developed, such as antibacterial, antiviral, anti-tumor and other drugs, which play a crucial role in human health protection.
In the field of materials science, 2-bromo-3-fluoro-4-methylpyridine also shows unique uses. It can be used as a building unit to participate in the synthesis of high-performance polymers or functional materials. By polymerizing with other monomers or compounds, it can endow materials with unique electrical, optical or mechanical properties, such as the preparation of materials with special electrical conductivity, or luminescent materials for the manufacture of optoelectronic devices, etc., providing rich possibilities for the development of new materials.
In the field of pesticide chemistry, this compound has also been used. After rational molecular design and modification, pesticide products with high insecticidal, bactericidal or herbicidal activities can be synthesized. With their precise mechanism of action and low environmental toxicity, these pesticides contribute to the sustainable development of modern agriculture, helping to improve the yield and quality of crops while reducing the adverse impact on the environment.
In conclusion, although 2-bromo-3-fluoro-4-methyl pyridine is an organic compound, it has a wide range of uses and key uses in many fields such as medicine, materials, pesticides, etc., and has made great contributions to promoting scientific and technological progress and industrial development in various fields.

The preparation of 2-bromo-3-fluoro-4-methylpyridine can be achieved by various methods. Firstly, bromine and fluorine atoms can be introduced by halogenation reaction starting from suitable pyridine derivatives. For example, under specific reaction conditions, using 4-methyl-containing pyridine compounds as substrates, selecting suitable brominating reagents, such as bromine (Br ²), under the catalysis of suitable catalysts, such as iron powder (Fe) or iron tribromide (FeBr < unk >), in a suitable solvent, such as dichloromethane, in a certain temperature range, such as 0-25 ° C, the reaction time, such as 1-3 hours, can introduce bromine atoms at specific positions in the pyridine ring to generate corresponding brominated products. After that, the bromopyridine derivative is used as a raw material, and an appropriate fluorination reagent, such as Selectfluor, is selected. In the presence of a base, such as potassium carbonate (K ² CO 🥰), in a suitable solvent, such as acetonitrile, at a certain temperature, such as 50-80 ° C, the reaction is carried out for a certain period of time, such as 6-12 hours, so as to introduce fluorine atoms to obtain the target product 2-bromo-3-fluoro-4-methylpyridine.
Second, it can also be synthesized by the strategy of constructing a pyridine ring. For example, the structure of the pyridine ring is first constructed through a multi-step reaction, and the methyl, bromide and fluorine atoms are introduced into the appropriate position at Pyridine rings can be formed by the reaction of nitrile compounds containing specific substituents with β-dicarbonyl compounds under suitable conditions, through cyclization, dehydration and other steps. For example, in the presence of acidic catalysts such as p-toluenesulfonic acid (p-TsOH), in high boiling point solvents such as toluene, heated and refluxed, such as 110-130 ° C, for a certain period of time, such as 8-12 hours, to form pyridine rings. Subsequent to appropriate functional group conversion, such as halogenation, bromine and fluorine atoms are precisely placed in the target position to obtain 2-bromo-3-fluoro-4-methylpyridine.
Furthermore, it can also be prepared by the coupling reaction catalyzed by transition metals. Using methyl-containing pyridine halides as raw materials, through transition metals such as palladium (Pd) or nickel (Ni), the coupling reaction occurs with brominating reagents and fluorinating reagents. For example, 4-methylpyridine bromide is used as a substrate, under the catalysis of palladium catalyst, such as tetrakis (triphenylphosphine) palladium (Pd (PPh < unk >) < unk >), with zinc bromide (ZnBr < unk >) and potassium fluoride (KF), in the presence of suitable ligands, such as tri-tert-butylphosphine (P (t-Bu) < unk >), in a suitable solvent, such as N, N-dimethylformamide (DMF), at a certain temperature, such as 80-100 ° C, the reaction time is certain, such as 10-15 hours, to achieve the introduction of bromine and fluorine atoms, to obtain 2-bromo-3-fluoro-4-methylpyridine This number method has its own advantages and disadvantages, and the actual synthesis needs to be based on the availability of raw materials, the ease of control of reaction conditions and the cost and many other factors.

2-Bromo-3-fluoro-4-methyl-pyridine is an organic compound, and its physical properties are of great interest. This substance is mostly liquid at room temperature, but the specific state is also affected by surrounding environmental factors. Looking at its color, it is usually almost colorless, but it may be slightly deviated due to the mixing of impurities.
Its boiling point is one of the key physical parameters. In view of the intermolecular force, containing atoms such as bromine and fluorine, the intermolecular force is enhanced, so the boiling point is relatively high. The exact boiling point value needs to be accurately determined by experiments, but the approximate range can be inferred by similar structural compounds. Generally speaking, the boiling point of such pyridine derivatives containing halogen atoms and methyl groups may be between 150 ° C and 250 ° C.
Melting point is also an important property. The regularity of molecular structure and the force of action have a great influence on the melting point. The molecular structure of the compound contains a variety of different atoms, and the structure is slightly complicated, resulting in its melting point or not very high. It is reasonably speculated that the melting point may be in the range of -20 ° C - 20 ° C, and the specific value still depends on the experimental determination.
In terms of density, the relative atomic mass of bromine and fluorine atoms is larger than that of common organic solvents. Or between 1.5 and 2.0 g/cm ³, and the specifics also vary depending on the experimental conditions and sample purity.
In terms of solubility, this compound has a certain polarity due to its pyridine ring, and should have good solubility in polar organic solvents such as ethanol and acetone; while in non-polar solvents such as n-hexane, the solubility may be poor.
In addition, the vapor pressure of 2-bromo-3-fluoro-4-methyl-pyridine is also worthy of attention. Due to the high boiling point, the vapor pressure at room temperature is relatively low, that is, the tendency to volatilize is small. However, with the increase of temperature, the vapor pressure will also increase accordingly.
In summary, the physical properties of 2-bromo-3-fluoro-4-methyl-pyridine are significantly affected by the atoms and groups in the molecular structure, and the exact values of many properties need to be determined experimentally and carefully.

2-Bromo-3-fluoro-4-methyl-pyridine is an organic compound with many unique chemical properties.
First, nucleophilic substitution reaction. Due to the high activity of bromine atoms, it is easy to be attacked by nucleophilic reagents and leave, thereby triggering nucleophilic substitution. If nucleophilic reagents such as alkoxides and amines are close, bromine atoms will be replaced. For example, the oxygen atoms in the alkoxides carry lone electrons to attack the carbon atoms connected to bromine, and then form new ether derivatives; the nitrogen atoms in amines can also be used as nucleophilic centers to replace bromine atoms to obtain new nitrogen-containing compounds.
Second, the activity difference of halogen atoms. Bromine and fluorine in the molecule are both halogen atoms, but bromine atoms are more likely to leave. This is because the carbon-bromine bond energy is smaller than that of the carbon-fluorine bond. In chemical reactions, the carbon-bromine bond is more likely to break, causing bromine atoms to participate in the reaction first. For example, under certain conditions, only the bromine atom is replaced, while the fluorine atom remains in the molecule.
Third, the pyridine ring is alkaline. There are lone pairs of electrons on the pyridine ring nitrogen atom, which makes it alkaline. In an acidic environment, nitrogen atoms can bind to protons to form pyridine salts. This property can be used to regulate the solubility and reactivity of the compound. For example, in some organic synthesis, converting it to pyridine salts can improve its solubility in polar solvents, which is conducive to the reaction.
Fourth, the influence of methyl groups. The presence of methyl groups at the 4-position affects the distribution of molecular electron clouds. Methyl groups are the power supply groups, which can increase the electron cloud density of the pyridine ring, especially in the ortho and para-position of the methyl group. This will affect the selectivity of the check point of the electrophilic substitution reaction. When the electrophilic reagent attacks, it is more inclined to the check point reaction with a higher electron cloud density. This is a key point to be considered when designing the reaction path in organic synthesis.
In conclusion, 2-bromo-3-fluoro-4-methyl-pyridine is rich in chemical properties and can be used as a key intermediate in the field of organic synthesis. By reacting to its different activity check points, various compounds containing pyridine structures can be prepared.

Today, there is 2-bromo-3-fluoro-4-methyl-pyridine. If you want to know the price range of 2-bromo-3-fluoro-4-methyl-pyridine in the market, it is difficult to determine the exact number of changes in the market. According to the theory of "Tiangong Kaiwu", the price of a product often depends on supply and demand, the difficulty of preparation, and the quality.
This 2-bromo-3-fluoro-4-methyl-pyridine, if its preparation method is complicated, requires concentrate, and takes labor hours, the price will be very high. And if there are many people who ask for it, and there are few who supply it, the price will also rise. On the contrary, if the system is easy, the material is easy to obtain, and the market supply is sufficient and the demand is thin, the price should be reduced.
According to the previous market price, the price may vary depending on the purity. For those with high purity, the price per gram may be between tens of yuan and more than 100 yuan; for those with less purity, the price may be lower, or between a few yuan and a few tens of yuan per gram. However, these are all approximate numbers. The market conditions are ever-changing, and it cannot be limited to this. The price may change from time to time due to changes in supply and demand, or due to new processes. In order to know the exact price, it is advisable to consult the sellers of this product in various cities, or refer to the trading platform of chemical materials, to get a near-real price.