2-bromo-3-cyanopyridine

2-Bromo-3-cyanopyridine is an organic compound with unique chemical properties. In this compound, the bromine atom is attached to the pyridine ring with a cyanyl group.
In terms of reactivity, the bromine atom is active and can participate in nucleophilic substitution reactions. Due to its electronegativity difference, bromine is easily attacked and left by nucleophilic reagents, and then new compounds are formed. For example, when reacted with alkoxides, ether derivatives can be formed; when reacted with amines, nitrogen-containing substitutions can be obtained.
Cyanyl groups are also active check points. Cyanyl groups can be hydrolyzed, and under acidic or alkaline conditions, carboxylic acids or carboxylates and ammonia are formed, respectively. The cyanyl group can also participate in the reduction reaction and can be reduced to an amine group, expanding its use in organic synthesis.
The pyridine ring itself has aromatic properties, making it relatively stable. However, due to the electron-absorbing interaction between bromine and cyanyl, the electron cloud density of the pyridine ring decreases, and the electrophilic substitution reactivity changes compared with that of pyridine. Electrophilic substitution is more likely to occur at relatively high electron cloud densities.
2-bromo-3-cyanopyridine exhibits various chemical reactivity due to the existence of bromine atoms and cyanyl groups. It has a wide range of uses in the field of organic synthesis and can be used in the preparation of drugs, pesticides and functional materials.

2-Bromo-3-cyanopyridine is also an important intermediate in organic synthesis. There are several common synthesis methods.
One is the halogenation method using 3-cyanopyridine as the raw material. Among them, 3-cyanopyridine reacts with brominating reagents, such as liquid bromine, N-bromosuccinimide (NBS), etc., under appropriate conditions. If liquid bromine is used, it is often required to be used in a solvent such as carbon tetrachloride and catalyzed by a suitable catalyst such as iron powder or iron tribromide. 2-Bromo-3-cyanopyridine is obtained by replacing the hydrogen atom at the 2-position of the pyridine ring with a bromine atom. The raw materials for this method are easily available, but the reaction conditions need to be carefully regulated to prevent the formation of polyhalogenated by-products.
The second is synthesized by using a pyridine derivative as the starting material through a multi-step reaction. Appropriate substituent modifications of the pyridine ring are first carried out to introduce a cyanyl group, followed by the introduction of a bromine atom in a suitable step. For example, a specific substituted pyridine can be prepared first, and then a cyanide group can be introduced through a cyanation reaction, and then a bromine atom can be introduced at Although this approach is slightly complicated, it can precisely control each step of the reaction, which is conducive to improving the purity and yield of the target product.
Third, there are also synthesis methods based on metal catalytic coupling reactions. Substrates containing pyridine structures are selected, and reagents containing bromine and cyanyl groups are selected. Under the action of metal catalysts such as palladium catalysts, a coupling reaction occurs to construct the structure of 2-bromo-3-cyanopyridine. Such methods have mild conditions and high selectivity, but the cost of metal catalysts is higher, and the reaction equipment and operation requirements are also stricter. < Br >
Each method for the synthesis of 2-bromo-3-cyanopyridine has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material availability, cost, yield and purity requirements, and choose carefully.

2-Bromo-3-cyanopyridine is an important compound in organic synthesis, which is widely used in the fields of medicine, pesticides, and materials science.
In the field of medicine, it can be used as a key intermediate to synthesize many biologically active compounds. For example, it can be used to prepare pyridine derivatives with specific pharmacological activities, which may have antibacterial, antiviral, and antitumor effects. Through a carefully designed reaction route, 2-bromo-3-cyanopyridine can be combined with other compounds with specific structures to construct molecules with complex structures and unique biological activities, laying the foundation for the development of new drugs.
In the field of pesticides, 2-bromo-3-cyanopyridine also plays an important role. Using it as a starting material, through a series of chemical reactions, high-efficiency pesticides, fungicides and other pesticide products can be prepared. Its unique chemical structure endows the synthesized pesticide with a specific mechanism of action, or can more accurately act on specific targets of pests or pathogens, thereby improving the control effect of pesticides, and the impact on the environment is relatively small, in line with the development trend of modern green pesticides.
In the field of materials science, 2-bromo-3-cyanopyridine can participate in the synthesis of functional materials. For example, in the preparation of organic optoelectronic materials, introducing them into the molecular structure of materials can adjust the photoelectric properties of materials, such as fluorescence emission wavelength, charge transfer ability, etc. With this, excellent organic Light Emitting Diode (OLED) materials and solar cell materials may be prepared, which will promote the development and innovation of the field of materials science.
In short, 2-bromo-3-cyanopyridine has shown great application potential in many fields such as medicine, pesticides, and materials science, and plays an important role in promoting technological progress and Product Research & Development in various fields.

I think what you are asking is the market price of 2-bromo-3-cyanopyridine. However, the market price of this product often changes due to various factors such as time and place, supply and demand, quality, etc., and it is difficult to determine the price.
If in the past, if you wanted to know the price of this product, merchants often went to the city, visited various pharmaceutical stores and workshops, inquired about its price, and then comprehensively considered it before they could get a rough estimate. However, today is different from the past. The market has changed greatly, and the flow of information is also fast.
Today's price request can be searched on the e-commerce platform for the name of this product, and the price marked by various merchants can be viewed. However, this price may vary depending on the amount and the distance of purchase. Or ask the distributor of chemical raw materials, he often knows the current market, and can tell the range of recent prices.
There is also a platform for chemical information, on which there are analysis and statistics of various raw material prices. If you search for this thing, you can get the recent price trend and approximate price. However, the market is impermanent, and the price is like a flowing water, changing rapidly. The price obtained can only be used as a reference for the moment, not a long-term evidence. Therefore, in order to know the real-time price, you need to constantly observe the changes in the market and ask the industry.

2-Bromo-3-cyanopyridine is an important compound in organic chemistry. Regarding its safety and precautions, it needs to be examined in detail.
First of all, safety, this compound has certain toxicity. The presence of its bromine atom and cyanyl group makes it harmful to the human body when it comes into contact with it. If its dust is inadvertently inhaled, it can irritate the respiratory tract, cause cough, asthma and other diseases. And if its dust comes into contact with the skin, it may cause skin allergies, redness and swelling. If it enters the eyes by mistake, it will cause great irritation to the eyes, or cause eye pain and blurred vision. In addition, it also has potential hazards in the environment, if it is released at will, or pollutes soil and water sources.
As for precautions, when handling this compound, it is necessary to wear appropriate protective clothing, such as laboratory clothes, protective gloves, etc., to prevent skin contact. Appropriate respiratory protective equipment, such as gas masks, should also be worn to prevent dust inhalation. The operation should be carried out in a well-ventilated environment, preferably in a fume hood, so that harmful gases can be discharged in time. After taking it, the remaining items must not be discarded at will, and should be properly disposed of according to regulations. When storing, it should be placed in a cool, dry and ventilated place, away from fire and heat sources, and should be stored separately from oxidants and acids to avoid dangerous reactions.
In summary, when handling 2-bromo-3-cyanopyridine, it is necessary to strictly follow safety procedures and treat it with caution to prevent accidents and ensure personal and environmental safety.