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What are the main uses of 2-BROMO-3-CHLORO-5-AMINOPYRIDINE?
2-Bromo-3-chloro-5-aminopyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. Due to the unique structure of this compound, it can introduce other functional groups through various chemical reactions, so as to construct a molecular structure with specific pharmacological activities.
It also plays an important role in the creation of pesticides. By chemically modifying it, a series of compounds with high insecticidal, bactericidal or herbicidal activities can be derived. The presence of bromine, chlorine and amino groups in its structure endows the molecule with unique electronic effects and spatial effects, and can interact with specific targets in organisms to achieve ideal biological activities.
In addition, in the field of materials science, 2-bromo-3-chloro-5-aminopyridine may also be used as a basic raw material for the construction of special functional materials. Through rational molecular design and synthesis strategies, it can be integrated into polymer materials or organic semiconductor materials to impart novel electrical, optical or mechanical properties to the materials.
What are the physical properties of 2-BROMO-3-CHLORO-5-AMINOPYRIDINE?
2-Bromo-3-chloro-5-aminopyridine is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
First of all, its appearance is usually white to light yellow solid powder. This color and morphology are remarkable in laboratory observation and preliminary identification. From the visual, the purity and physical state can be preliminarily judged.
Second, the melting point is between 140-145 ° C. The melting point is the temperature limit of the substance from solid to liquid, which is extremely critical. Accurate determination of melting point not only allows to test its purity, but also serves as an important reference in the process of synthesis and purification. If the melting point deviates from the normal range, or implies the mixing of impurities, its chemical properties will be affected.
In addition, its solubility also has characteristics. In common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), it has a certain solubility. In dichloromethane, it can be moderately dissolved due to the intermolecular force between the two molecules. This property is quite useful in the reaction operation of organic synthesis and product separation steps. In DMF, the solubility is better, because of its polarity, it can provide a good reaction environment for some reactions and promote the progress of the reaction.
And its stability is also a key consideration. Under normal temperature and pressure, if there are no improper storage conditions, this compound is quite stable. In case of hot topics, open flames or strong oxidants, the stability will be broken or dangerous chemical reactions will be triggered. Therefore, when storing, it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants.
The physical properties of 2-bromo-3-chloro-5-aminopyridine, such as appearance, melting point, solubility and stability, are all indispensable key factors in chemical research, organic synthesis and related industrial applications, and need to be carefully paid attention to and precisely controlled.
What are 2-BROMO-3-CHLORO-5-AMINOPYRIDINE synthesis methods?
The synthesis of 2-bromo-3-chloro-5-aminopyridine is an important research direction in the field of organic synthesis. To synthesize this substance, there are several common methods.
One is to start from a suitable pyridine derivative. Through a halogenation reaction, bromine and chlorine atoms are introduced at specific positions in the pyridine ring. For example, first, a suitable halogenating agent is used to introduce bromine and chlorine at the corresponding check point of the pyridine ring to form a bromine and chlorine-containing pyridine intermediate. Subsequently, for the introduction of amino groups, an aminolysis reaction can be selected. Using ammonia or ammonia derivatives as reagents, substitution reactions occur with halogenated pyridine intermediates to generate amino groups at specific positions to achieve the synthesis of 2-bromo-3-chloro-5-aminopyridine.
Second, the strategy of constructing a pyridine ring can also be used. Select chain compounds containing suitable substituents and form pyridine rings through cyclization. During the cyclization process, or after cyclization, with the help of appropriate reaction conditions, bromine, chlorine and amino groups are introduced in sequence. This approach requires precise control of the reaction conditions to ensure that each substituent can be accurately positioned to the target position.
Third, the catalytic coupling reaction is also a feasible method. Palladium, copper and other metal catalysts are used to promote the coupling reaction between bromine and chlorine-containing pyridine derivatives and amino-containing reagents. This method requires careful selection of catalysts and ligands, optimization of reaction conditions, in order to improve the yield and selectivity of the reaction, and successfully synthesize 2-bromo-3-chloro-5-aminopyridine.
Each synthesis method has its advantages and disadvantages. In actual operation, the most suitable synthesis route should be selected based on the availability of starting materials, the difficulty of reaction conditions, the purity and yield requirements of target products, and many other factors.
What 2-BROMO-3-CHLORO-5-AMINOPYRIDINE need to pay attention to when storing and transporting
2-Bromo-3-chloro-5-aminopyridine is an important chemical raw material in organic synthesis. When storing and transporting this chemical, many key matters need to be paid attention to.
Bear the brunt, storage temperature is crucial. It should be stored in a cool place to prevent chemical reactions or even deterioration due to excessive temperature. Excessive temperature may cause its decomposition, which in turn affects its quality and effectiveness. Therefore, the warehouse temperature should be maintained in a suitable range, generally speaking, it is better not to exceed 30 ° C.
Furthermore, humidity should not be underestimated. This chemical needs to be stored in a dry place, due to humid environment or cause it to absorb moisture. After absorbing moisture, caking may occur, or even react with moisture to change its chemical properties. Therefore, the humidity of the storage environment should be controlled below 60%, and the environment can be kept dry by means of desiccants.
In addition, make sure that the package is well sealed when storing. If the package is damaged, the outside air, moisture and other substances are easy to come into contact with it, causing oxidation and other reactions. Sealed packaging can effectively isolate external adverse factors and ensure its chemical stability.
When transporting, there are also many precautions. This chemical needs to be properly fixed to prevent packaging damage due to collisions and bumps during transportation. And the means of transportation must have good ventilation conditions to avoid safety hazards caused by rising temperature and gas accumulation during transportation.
Furthermore, transportation personnel must be familiar with the characteristics of this chemical and emergency treatment methods. In the event of an unexpected situation such as leakage, rapid and correct response measures can be taken, such as evacuation of crowds, disposal of leaks, etc., to minimize the harm.
In conclusion, the storage and transportation of 2-bromo-3-chloro-5-aminopyridine requires thorough consideration in terms of temperature, humidity, packaging, protection during transportation, and personnel training, so as to ensure its safety and quality are not affected.
What is the market price range for 2-BROMO-3-CHLORO-5-AMINOPYRIDINE?
2-Bromo-3-chloro-5-aminopyridine, the price of this product in the market is difficult to determine. The range of its price often changes due to multiple reasons.
The first to bear the brunt is the scale of production. If the workshop has a large number of people and the output is quite large, according to the common sense of supply and demand in the city, its price may be affordable. On the contrary, if the system is small and the output is small, the price will be high.
Furthermore, the price of raw materials is also a major factor. The preparation of 2-bromo-3-chloro-5-aminopyridine requires all kinds of raw materials, and the rise and fall of the price of raw materials directly affects its cost. If the price of raw materials rises, the price of finished products will also rise; if the price of raw materials is depressed, the price of finished products may be lowered.
In addition, the quality of the quality also affects the price. Those with high quality may be more valuable to the user, so the price may be high; and those with lower quality, the price should be lower.
The price of 2-bromo-3-chloro-5-aminopyridine in the market varies from tens to hundreds of yuan per gram. However, this is only an approximate figure, and the actual transaction price depends on the market conditions, supply and demand, quality level, etc. at that time. To know the exact price, you must carefully study the market at that time and consult the industry.