2-Bromo-3-amino-5-chloropyridine

2-Bromo-3-amino-5-chloropyridine is an important member of organic compounds. Its main uses are quite extensive, and it is often used as a key intermediate in the field of medicinal chemistry. The road of pharmaceutical creation, the synthesis of many drugs depends on this as the basis. Due to its unique structure, it can use chemical methods to ingeniously react with other compounds to construct complex drug molecular structures, thus paving the way for the research and development of new drugs.
In the field of pesticide chemistry, it also has a presence. With its own chemical activity, it can participate in the synthesis of pesticide ingredients with specific biological activities. Such ingredients may be effective against specific pests, pathogens, etc., to help agricultural production resist the invasion of pests and diseases, maintain the robust growth of crops, and protect the harvest.
Furthermore, in the emerging field of materials science, it also has potential uses. With the rapid development of science and technology, the demand for special performance materials is increasing. 2-Bromo-3-amino-5-chloropyridine may intervene in the material synthesis process, endowing materials with different physical and chemical properties, such as improving the stability and conductivity of materials, which contributes to the innovative development of materials science.

To prepare 2-bromo-3-amino-5-chloropyridine, there are several common methods.
First, it can be started from a suitable pyridine derivative. Before the introduction of chlorine atoms on the pyridine ring, chlorine reagents, such as thionyl chloride, phosphorus oxychloride, etc., are often used to make the pyridine ring undergo electrophilic substitution under suitable reaction conditions to obtain chlorine-containing pyridine derivatives. This process requires attention to the reaction temperature, time and ratio of the reactants to ensure that the chlorine atoms are accurately introduced into the desired position.
Then, bromine atoms are introduced. Brominating reagents such as bromine, N-bromosuccinimide (NBS), etc. can be selected. When bromine is substituted with bromine, a catalyst such as iron powder may be required to assist, and the bromine atom is connected to the pyridine ring through electrophilic substitution to obtain a pyridine intermediate containing both chlorine and bromine.
Finally, an amino group is introduced. Generally, an aminolysis reaction is used, and ammonia or ammonia derivatives are used as the amino source. In an appropriate solvent, such as an alcohol solvent, under heating and pressure, the chlorine-containing, bromine-containing pyridine intermediates are reacted with the amino source, and the halogen atom is replaced by an amino group to obtain 2-bromo-3-amino-5-chloropyridine.
Second, a strategy to gradually build a pyridine ring can also be considered. First, the pyridine ring structure is constructed by multi-step reaction with small molecule compounds containing chlorine and bromine as raw materials. During the construction process, the reaction steps are cleverly designed to make the chlorine and bromine atoms in the appropriate position, and finally the amino group is introduced to achieve the purpose of preparing the target product. Although this strategy may be more complicated, the control of the reaction check point may be more accurate.
When preparing 2-bromo-3-amino-5-chloropyridine, the optimization of the reaction conditions in each step is extremely critical, and many factors such as reactant activity, solvent effect, and catalyst selection need to be considered comprehensively to improve the yield and purity of the product.

2-Bromo-3-amino-5-chloropyridine is one of the organic compounds. Its physical properties are very important, and it is related to its performance in various chemical processes and practical applications.
Looking at its properties, under room temperature and pressure, 2-bromo-3-amino-5-chloropyridine is often in a solid state. The appearance of this solid, either powdered or crystalline, varies slightly depending on the preparation conditions and purity. Powdered, the particles are fine and the fluidity is good; crystalline, it has a regular crystal structure, crystal clear.
When it comes to melting point, the specific melting point of this compound is one of its important physical markers. Accurate determination of melting point can help to distinguish its purity and authenticity. The value of melting point is roughly within a certain range due to slightly different accuracy of measurement methods and instruments. Knowing the melting point is of great significance for chemical operations such as heating treatment, separation and purification, and can control the temperature accordingly to achieve the expected chemical transformation.
Solubility is also a key physical property. 2-Bromo-3-amino-5-chloropyridine has different solubility in different solvents. In common organic solvents, such as ethanol, dichloromethane, acetone, etc., it may have a certain solubility. In ethanol, with the increase of temperature, the solubility may increase. This is due to the increase of temperature, the thermal motion of molecules intensifies, and the interaction between solvent and solute molecules is enhanced. In water, its solubility may be limited, due to the structural characteristics of the compound, the polarity does not match well with water, resulting in weak interaction with water molecules.
Density cannot be ignored. Its density is the mass per unit volume, and the specific value reflects the compactness of the substance. Measuring density is of great significance for experimental operations such as accurate weighing and formulation of solutions, which can ensure the accuracy and repeatability of chemical experiments.
In addition, the vapor pressure of this compound is very low. Vapor pressure is the pressure of a substance at a certain temperature when it is in equilibrium with its gas. The vapor pressure is low, indicating that it has a small tendency to volatilize at room temperature, is relatively stable during storage and operation, and is not easy to be lost due to volatilization or cause environmental pollution.
In summary, the physical properties of 2-bromo-3-amino-5-chloropyridine, such as properties, melting point, solubility, density and vapor pressure, are important for the research and application of this compound, and play a key role in many fields such as organic synthesis and drug development.

2-Bromo-3-amino-5-chloropyridine is one of the organic compounds. Its chemical properties are particularly important and are related to many organic synthesis reactions.
In this compound, bromine, amino group and chlorine atoms each show unique properties. Bromine atoms have considerable activity and often play the role of leaving groups in nucleophilic substitution reactions. Due to the high electronegativity of bromine atoms, the carbon-bromine bond is easily broken, so it can be attacked by nucleophiles, which in turn triggers a substitution reaction and forms a novel carbon-nucleophilic bond.
Amino (-NH2O) is alkaline and nucleophilic. The nitrogen atom of the amino group is rich in lone pairs of electrons and can attack atoms or groups that lack electrons. In organic synthesis, amino groups can undergo nucleophilic substitution reactions with halogenated hydrocarbons, acyl halides, etc., to form amine derivatives. And amino groups can participate in many condensation reactions, such as reacting with aldides or ketones to form imines.
Furthermore, although chlorine atoms are slightly less active than bromine atoms, they can also participate in specific nucleophilic substitution reactions. Under certain conditions, chlorine atoms can be replaced by other nucleophilic groups, thereby changing the molecular structure.
The chemical properties of 2-bromo-3-amino-5-chloropyridine make it have the potential to be widely used in many fields such as medicine, pesticides and materials science. Due to its diverse reactivity, chemists can ingeniously design reaction routes to convert it into organic molecules with complex structures and specific functions.

I don't know what the price range of 2-bromo-3-amino-5-chloropyridine is in the market. However, if you want to check its price, you can go to the chemical raw material trading platform and the official website of the chemical reagent supplier. These platforms and merchants often list the price of various chemicals, or the price varies depending on the purity, packaging, and purchase quantity.
Or go to the chemical market in person to inquire about the merchants and get first-hand price information. If the purchase volume is large, negotiate with the supplier, or get a preferential price.
Furthermore, refer to past transaction records, industry reports, or know the approximate price range. However, the price of chemical products often fluctuates due to changes in raw material costs, market supply and demand, policies and regulations, etc. Therefore, in order to obtain an accurate price, the real-time inquiry shall prevail.