2-Bromo-3,5-difluoropyridine

2-Bromo-3,5-difluoropyridine is an important chemical substance in organic synthesis. Its main uses can be divided into several ends.
First, in the field of medicinal chemistry, it is often used as a key intermediate. In the process of drug development, many molecules with specific biological activities need to be constructed as starting materials. Due to its unique chemical structure, it contains bromine and fluorine atoms, which can participate in a variety of organic reactions, such as nucleophilic substitution reactions. With this reaction, various functional groups can be introduced to construct drug molecules with high affinity to biological targets. For example, in the preparation of drugs for certain viral or tumor-related targets, 2-bromo-3,5-difluoropyridine can be used as a starting module and modified through a series of reactions to obtain lead compounds with ideal pharmacological activity, laying the foundation for the development of new drugs.
Second, in the field of materials science, it also has important applications. In the preparation of organic optoelectronic materials, this compound can be polymerized to construct polymer materials with specific optoelectronic properties. Due to the introduction of fluorine atoms, the electron cloud distribution of the material can be adjusted, which in turn affects the optical and electrical properties of the material. For example, when preparing organic Light Emitting Diode (OLED) materials, polymers constructed from 2-bromo-3,5-difluoropyridine as raw materials may exhibit unique luminous properties, such as high luminous efficiency and specific luminous wavelengths, providing new material options for the development of OLED technology.
Third, in the basic research of organic synthetic chemistry, 2-bromo-3,5-difluoropyridine is often used as a model compound. By studying various reactions it participates in, such as metal-catalyzed coupling reactions, researchers can further explore the reaction mechanism, optimize the reaction conditions, and develop new organic synthesis methods. This not only enhances the understanding of the nature of organic reactions, but also provides theoretical support and practical experience for the efficient synthesis of complex organic molecules.

The synthesis method of 2-bromo-3,5-difluoropyridine, although the ancient book "Tiangong Kaiwu" does not contain the synthesis of this specific substance, it can be deduced from the ancient chemical process ideas.
The ancient chemical process relies on natural things and is required by physical and chemical changes. To form 2-bromo-3,5-difluoropyridine, a natural substance containing pyridine ring, bromine and fluorine can be found as the starting point. However, this substance is difficult to find in the world, so it needs to be constructed manually with simple raw materials.
One, can be started from pyridine. Pyridine is halogenated and bromine and fluorine are introduced. First, introduce bromine atoms at a specific position of pyridine with a suitable halogenating agent. This requires controlling the reaction conditions, such as temperature, solvent, catalyst, etc. When brominating, choose the appropriate brominating agent, such as liquid bromine, N-bromosuccinimide (NBS), etc. Liquid bromine has high activity and fast reaction, but the selectivity is slightly worse; NBS has good selectivity. According to the structural characteristics of pyridine, the bromine atom is conditioned to fall into the second position.
Then, fluoride. The method of fluorination can be used with fluorine-containing reagents, such as potassium fluoride, in the appropriate reaction system, so that the fluorine atom is connected to the 3rd and 5th positions. This process requires attention to the reaction activity and selectivity. Due to the high activity of fluorine atoms, the reaction is easy to get Or other active check points on the pyridine ring can be protected first, and then the protective group can be de-protected after fluorination.
Second, other nitrogen-containing heterocycles can also be used as starting materials, and they can be obtained through a series of reactions such as cyclization and halogenation. For example, the nitrogen-containing unsaturated chain compound is cyclized to form a pyridine ring within the molecule, and then halogenated to introduce bromine and fluorine. The choice of starting materials and the control of cyclization conditions are the key in this approach. Cyclization requires a suitable catalyst and reaction temperature to make the chain molecules ring in the desired way. The halogenation step is the same as before, and the conditions are carefully adjusted to achieve the synthesis of the target product. < Br >
Although there is no such precise synthesis method in ancient books, the synthesis path of 2-bromo-3,5-difluoropyridine can be explored by using the ancient chemical process ideas, through the selection of raw materials and the regulation of reaction conditions.

2-Bromo-3,5-difluoropyridine is also an organic compound. Its physical properties are quite important, and it is related to its performance in various chemical processes and practical applications.
First of all, its appearance, under normal temperature and pressure, 2-bromo-3,5-difluoropyridine is often colorless to light yellow liquid, clear and with a specific luster. This appearance characteristic is crucial for the preliminary identification and observation of its state changes.
Melting point and boiling point. Its melting point is about -40 ° C, and its boiling point is between 170-175 ° C. The low melting point indicates that the substance can be converted from a solid state to a liquid state in a relatively low temperature environment; the value of the boiling point determines the temperature range at which it can be converted to a gaseous state under heating conditions. These two are key considerations in the process of separating, purifying and storing this substance.
Furthermore, density is also an important physical property. Its density is about 1.8g/cm ³, which is heavier than water. When placed in water, this substance will sink to the bottom. This property is of great significance in chemical operations involving liquid-liquid separation.
In terms of solubility, 2-bromo-3,5-difluoropyridine is soluble in common organic solvents such as dichloromethane, chloroform, and ether. However, the solubility in water is not good. This difference in solubility provides a basic basis for the selection of solvents for participating in various organic reactions.
In addition, its vapor pressure and volatility cannot be ignored. Although it is not a highly volatile substance, some molecules will still escape into the gas phase at appropriate temperatures and environments. Understanding its vapor pressure is instructive for ventilation design involving gas phase reactions or storage environments.
In summary, the physical properties of 2-bromo-3,5-difluoropyridine, from appearance to melting point, density, solubility and vapor pressure, are interrelated, and together build its basic characteristics in the chemical field, laying the foundation for subsequent research, production and application.

The market price of 2-bromo-3,5-difluoropyridine is difficult to determine. The price of this product often varies due to various factors, such as supply and demand, difficulty in preparation, price of raw materials, and competition in the market.
Looking at the market of chemical raw materials in the past, the supply and demand ends are the key. If there are many applicants for this product, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall. The difficulty of its production method also has a great impact. If the preparation method is complicated, requires multiple processes, takes a long time and consumables, and the cost is high, the price is also expensive. The price of raw materials should not be ignored. If the raw materials are expensive, the cost of this compound will also increase, which will increase the market price.
Competition in the market also affects its price. If there are many merchants in the city competing with each other for sale, it is a competition for customers, or there is a price reduction, and the price will be lower because of it; if there are few merchants, it is almost a monopoly, and the price may be higher.
Although it is difficult to determine the specific market price, if you want to know the current price of 2-bromo-3,5-difluoropyridine, you can consult the chemical raw material trading platform, relevant chemical product suppliers, or refer to industry reports and market survey data to obtain more accurate price information.

2-Bromo-3,5-difluoropyridine is a reagent commonly used in organic synthesis. When storing and transporting, many things need to be paid attention to.
The first word of storage, because it has a certain chemical activity, should be stored in a cool, dry and well-ventilated place. This can avoid its qualitative change due to temperature and humidity discomfort. If placed in a high temperature environment, or cause its volatilization to intensify, and even cause chemical reactions; humid places can also make it interact with water vapor and damage its purity. And should be kept away from fire, heat sources, because of open flames, hot topics, or the risk of combustion and explosion.
Furthermore, the storage of this substance should be separated from oxidants, acids, alkalis, etc., and must not be mixed. The cover is prone to violent reactions due to its active chemical properties and contact with the above substances, endangering safety. The storage area needs to be equipped with suitable materials to contain leaks, just in case of leakage, which can be dealt with in time to avoid greater harm.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is secure before transportation. The packaging should be able to withstand a certain external force to prevent it from being damaged during transportation. During transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. The transportation vehicle also needs to be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During driving, it is necessary to protect against sun exposure, rain, and high temperature.
At the same time, the exhaust pipe of the vehicle transporting the chemical must be equipped with a fire retardant device, and it is forbidden to use the mechanical equipment and tools that are prone to generating sparks for loading and unloading. When transporting by road, it should be driven according to the specified route, and do not stop in residential areas and densely populated areas; when transporting by rail, it should not be slipped away. In this way, the safety of 2-bromo-3,5-difluoropyridine during storage and transportation should be guaranteed to avoid harm to personnel and the environment.