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2-Bromo-3, what is the main use of 5-dichloro-6-methylpyridine?
2-Bromo-3,5-dichloro-6-methylpyridine is a class of organic compounds. It has a wide range of uses and is often used as a key intermediate in the creation of new pesticides in the field of pesticides. The special structure of the geinpyridine ring endows the compound with unique biological activity, which can be chemically modified and transformed to produce pesticide products with high insecticidal, bactericidal or herbicidal effects.
In the field of medicinal chemistry, 2-bromo-3,5-dichloro-6-methylpyridine is also important. It may be used as a starting material for the synthesis of specific drug molecules, and complex drug skeleton structures can be constructed by organic synthesis. The chemical properties of this pyridine derivative contribute to the optimization of drug activity, selectivity and pharmacokinetic properties.
Furthermore, in the field of materials science, it may be involved in the synthesis of functional materials. For example, reacting with other organic or inorganic components to prepare materials with specific photoelectric properties for the fabrication of organic Light Emitting Diodes, solar cells and other devices.
Due to the presence of halogen atoms and methyl groups in its structure, 2-bromo-3,5-dichloro-6-methylpyridine has become an important building block in organic synthetic chemistry. It can construct more complex and diverse organic compounds through nucleophilic substitution, coupling and other reactions, providing rich raw materials and possibilities for the development of organic synthetic chemistry.
2-Bromo-3, what are the synthesis methods of 5-dichloro-6-methylpyridine
To prepare 2-bromo-3,5-dichloro-6-methylpyridine, there are many methods, and the main ones are selected as follows.
First, use 2-methyl-3,5-dichloropyridine as the starting material. Shilling it meets the brominating agent, such as N-bromosuccinimide (NBS) as the brominating agent in a suitable solvent, with the help of light or initiator, the bromine atom can replace the hydrogen on the methyl group, so 2-bromo-3,5-dichloro-6-methylpyridine is obtained. The beauty of this approach is that the reaction conditions are relatively easy to control, and there are few side reactions, and the purity of the product is quite high.
Second, start from 2,6-dimethyl-3,5-dichloropyridine. First, the methyl group is oxidized, and 2-carboxyl-3,5-dichloro-6-methylpyridine can be obtained by suitable oxidants, such as potassium permanganate. After the carboxyl group is reduced to a halide, it is reduced to a methyl group by a reducing agent, and bromine atoms are introduced with a brominating agent. After a multi-step reaction, the target product can also be obtained. However, this path step is slightly complicated, and each step of the reaction needs to be carefully adjusted to preserve the yield and purity.
Third, use 3,5-dichloro-6-methylpyridine-2-alcohol as the starting material. Make this alcohol react with bromine-containing reagents, such as phosphorus tribromide (PBr
), etc. The hydroxyl group of the alcohol can be replaced by a bromine atom, so that 2-bromo-3,5-dichloro-6-methylpyridine can be obtained. This method is relatively direct and easy to operate, but it is necessary to pay attention to the selection of reagents and reaction conditions to prevent unnecessary side reactions.
All these methods have their own advantages and disadvantages. In the actual preparation, according to the availability of raw materials, cost considerations, yield and purity requirements and other factors, the appropriate method can be carefully selected to efficiently prepare 2-bromo-3,5-dichloro-6-methylpyridine.
2-Bromo-3, what are the physical properties of 5-dichloro-6-methylpyridine
2-Bromo-3,5-dichloro-6-methylpyridine, this is an organic compound with unique physical properties.
Under normal temperature and pressure, it is mostly a colorless to light yellow liquid. This state is due to the intermolecular forces and structural characteristics. Its boiling point is in a specific range, about 200-220 ° C. Due to the strength of the chemical bonds between the atoms in the molecule and the interaction between the molecules, it needs to reach this temperature before it can be converted from liquid to gaseous.
The melting point of this compound is also fixed, roughly -10-0 ° C. This temperature reflects the transformation of the molecular lattice arrangement from order to disorder. Its density is about 1.6-1.7 g/cm ³, which is heavier than water. Due to the presence of relatively large atoms such as bromine and chlorine in the molecule, the mass per unit volume increases.
In terms of solubility, in organic solvents such as dichloromethane and chloroform, 2-bromo-3,5-dichloro-6-methylpyridine has good solubility. Due to the principle of "similar miscibility", its organic structure is similar to that of organic solvents, which is conducive to mutual penetration and dispersion; in water, its solubility is very small, because its molecular polarity is weak, and the force between water molecules is difficult to match the hydrogen bond between water molecules.
In addition, 2-bromo-3,5-dichloro-6-methylpyridine is volatile to a certain extent, and it will evaporate slowly in the air, emitting a special odor. Although it is not odorous and pungent, it is also unique. This is due to the tendency of its molecules to escape from the liquid phase at room temperature.
In summary, the physical properties of 2-bromo-3,5-dichloro-6-methylpyridine are determined by its molecular structure and atomic composition. These properties are of great significance for its application in organic synthesis and other fields.
2-Bromo-3, what are the chemical properties of 5-dichloro-6-methylpyridine
2-Bromo-3,5-dichloro-6-methylpyridine, an organic compound, has unique chemical properties and is widely used in the field of organic synthesis.
In terms of its activity, bromine atoms are highly active. Due to the large electronegativity of bromine atoms and the relatively small bond energy of C-Br, nucleophilic substitution reactions are prone to occur. For example, in the case of nucleophilic reagents, such as sodium alcohols and amines, bromine atoms can be replaced by nucleophilic reagents. If reacted with sodium ethanol, bromine atoms may be replaced by ethoxy groups to form corresponding ether compounds; if reacted with amines, nitrogen-containing derivatives can be formed, which is of great significance in drug synthesis and preparation of fine chemicals.
Furthermore, the chlorine atom on the pyridine ring can also participate in the reaction, but its activity is slightly weaker than that of the bromine atom. Under certain conditions, chlorine atoms can also undergo nucleophilic substitution reactions, and selective substitution of chlorine atoms can be achieved by changing the reaction conditions and selecting suitable nucleophilic reagents.
The presence of methyl groups also affects the properties of the compound. The presence of methyl groups as power supply groups increases the electron cloud density of the pyridine ring, which affects the reactivity of the pyridine ring to a certain extent, and methyl groups can undergo some specific reactions, such as methyl groups can be oxidized to carboxyl groups under the action of appropriate oxidants.
In addition, the pyridine ring of 2-bromo-3,5-dichloro-6-methylpyridine has aromatic properties and can undergo aromatic electrophilic substitution reactions. However, due to the localization effect of substituents such as bromine, chlorine, and methyl, the reaction check point and activity will be affected accordingly. For example, when electrophilic reagents attack the pyridine ring, they will mainly substitution reactions at specific positions according to the localization rules of the substituents.
In short, 2-bromo-3,5-dichloro-6-methylpyridine provides rich possibilities for organic synthesis chemistry due to its diverse chemical properties. Organic compounds with complex structures and different functions can be prepared through various reactions.
2-Bromo-3, what is the price range of 5-dichloro-6-methylpyridine in the market?
I don't know the exact price range of 2-bromo-3,5-dichloro-6-methylpyridine in the market. However, "Tiangong Kaiwu" focuses on the techniques and production methods of Baigong, and does not involve the price of this product. To know the price, you can find it on the chemical raw material trading platform and chemical reagent supplier. Ask the merchant specializing in chemical products, or you can get a near-real price. In these ways, you can get a newer and accurate price. Due to the changeable supply and demand in the chemical market and the rise and fall of raw material costs, the price is constantly changing, and it is difficult to set a fixed range. If you want to know the details, you should follow the above path.