2-(Boc-amino)-4-bromopyridine

2-% 28Boc-amino% 29-4-bromopyridine, which is an important compound in organic chemistry. Its chemical properties are unique and need to be studied carefully.
Looking at its structure, it contains a pyridine ring, which is aromatic and stable in nature. The nitrogen atom of the pyridine ring has a solitary pair of electrons, which can be used as an electron donor and complexes with metal ions, which is quite useful in catalytic reactions. The bromine atom at the 4-position has high activity. It can be replaced by a variety of nucleophilic reagents, such as hydroxyl and amino groups, through nucleophilic substitution reactions, thereby introducing different functional groups and expanding the application range of the compound. < Br >
And 2-position (Boc-amino), that is, tert-butoxycarbonyl amino, has the effect of protecting amino groups. In organic synthesis, amino groups are active and easily participate in many unnecessary reactions. (Boc-amino) can stabilize amino groups. When the reaction is appropriate, tert-butoxycarbonyl can be removed under mild conditions to release free amino groups. This protective group has certain stability to acids and bases, and can effectively maintain the integrity of amino groups in multi-step synthesis.
In addition, the compound can participate in various reactions to construct complex organic structures due to its different activity check points. For example, through cross-coupling reaction, it reacts with other halogenated compounds or olefins to achieve the formation of carbon-carbon bonds, which lays the foundation for the synthesis of organic molecules with specific structures and functions.
In short, 2-% 28Boc-amino% 29-4-bromopyridine has broad application prospects in the field of organic synthesis due to its unique structure and rich chemical properties.

To prepare 2 - (Boc - amino) - 4 - bromopyridine, there are several common synthesis methods as follows.
First, 4 - bromopyridine is used as the starting material. Shilling 4 - bromopyridine reacts with Boc anhydride (ie di-tert-butyl dicarbonate) in a suitable solvent, such as dichloromethane, catalyzed by an organic base such as triethylamine. This base neutralizes the acid generated by the reaction and prompts the reaction to proceed forward. The nitrogen atom of 4 - bromopyridine nucleophilically attacks the carbonyl carbon of Boc anhydride, and then leaves a molecule of tert-butanol to obtain the target product. In this process, the solvent needs to be anhydrous, and the reaction temperature should be controlled at low temperature, such as between 0 ° C and room temperature, to avoid side reactions.
Second, start from 2-amino-4-bromopyridine. React 2-amino-4-bromopyridine with Boc acid anhydride under conditions similar to the above. Due to the strong nucleophilicity of the amino group, it is easy to react with Boc acid anhydride to form the desired 2- (Boc-amino) -4-bromopyridine. If the starting material of this route is not easy to obtain, 2-amino-4-bromopyridine can be prepared by multi-step reaction of pyridine derivatives.
Or, it is prepared by the construction and functionalization of pyridine rings. The pyridine ring is constructed first, for example, by using compounds containing nitrogen, carbonyl and bromine to form pyridine rings through a series of reactions such as condensation and cyclization, and then introducing Boc-amino groups. The steps of this method may be more complicated, but it may have advantages when specific starting materials are easily available. The reaction conditions of each step need to be carefully controlled to ensure the selectivity and yield of the reaction. In short, all synthesis methods have advantages and disadvantages, and the advantages should be selected according to the actual situation, such as the availability of raw materials, cost, and difficulty of reaction conditions.

2-% 28Boc - amino% 29 - 4 - bromopyridine is 2 - (tert-butoxycarbonyl amino) - 4 - bromopyridine, which is widely used in organic synthesis.
One is often used in the field of medicinal chemistry. The creation of drugs often requires the construction of complex molecular structures. This compound can be used as a key intermediate because of its pyridine ring and specific substituents. Pyridine rings have unique electronic properties and structural stability, which can impart specific biological activities and pharmacological properties to drug molecules. Tert-butoxycarbonyl amino can protect the amino group. During the reaction process, the amino group can be prevented from participating in the reaction without end. At an appropriate time, the protective group is removed and the amino group is allowed to play a role, so as to accurately construct the active structure of the drug containing the amino group. It is often seen in the synthesis path of many antibacterial and anti-tumor drugs.
Second, it is also useful in materials science. When synthesizing special functional materials, 2- (tert-butoxycarbonyl amino) -4-bromopyridine can participate in the construction of polymers or small molecule materials with specific photoelectric properties. Bromine atoms can introduce other functional groups through halogenation reactions and other means to change the electronic conductivity and luminescence properties of materials, laying the foundation for the development of new photoelectric materials.
Thirdly, it is a commonly used substrate in the study of organic synthesis methodologies. Chemists use its structural characteristics to explore novel reaction pathways and catalytic systems. Using it as a starting material, study the reaction mechanism and selectivity under different reaction conditions, develop efficient and green new methods of organic synthesis, and promote the development of organic synthetic chemistry.

2-% 28Boc-amino% 29-4-bromopyridine is an important compound commonly used in organic synthesis. During storage and transportation, all precautions should be taken with caution.
First words storage. This compound should be stored in a cool, dry and well-ventilated place. Due to high temperature and humidity, its chemical properties may change due to environmental factors. High temperature can promote its molecular activity to intensify, or trigger decomposition reactions; moisture can easily cause compounds to absorb moisture, affect purity, and even induce adverse reactions such as hydrolysis, causing its deterioration, so suitable temperature and humidity conditions are crucial.
Furthermore, storage should be kept away from kindling, heat sources and oxidants. Tinder, heat source or compounds catch fire and burn, and oxidizing agents have strong oxidizing properties, contact with them or cause violent chemical reactions, endangering safety. And this compound needs to be sealed and stored to prevent interaction with air components, such as oxygen, carbon dioxide, etc., resulting in quality damage.
As for transportation, it should not be underestimated. It is necessary to ensure that the packaging is intact to prevent the packaging from cracking due to bumps and collisions during transportation and compound leakage. The selected means of transportation must comply with relevant safety regulations, and should avoid mixing with other incompatible substances during transportation to avoid dangerous reactions. Transport personnel should also be familiar with the characteristics of this compound and emergency treatment methods. In case of emergencies, they can be disposed of quickly and properly to ensure safe transportation.
In summary, 2-% 28Boc - amino% 29 - 4 - bromopyridine must be treated with caution during storage and transportation, temperature and humidity control, fire prevention and oxidation prevention, sealed packaging and compliance with transportation.

Fu 2 - (Boc - amino) - 4 - bromopyridine is also a chemical raw material. Its market price often changes for many reasons, making it difficult to generalize.
First, the price of raw materials has a great impact. If the price of raw materials for preparing this compound rises or falls, the price of the finished product will also fluctuate. If the preparation of Boc - amino-related raw materials, if the supply is tight, the price will rise, and the cost of this compound will increase, and the market price will also be high.
Second, the technique of production is also the key. If there is a new way to reduce consumption and increase efficiency, the cost can be reduced, and the price may be lowered. On the contrary, if the process is cumbersome and expensive, the price will be high.
Third, market supply and demand determine the price. If there is strong demand for this product in many industries, such as pharmaceutical research and development, fine chemicals, etc., the demand exceeds the supply, and the price will tend to rise; if the demand is low, the supply exceeds the demand, and the price may drop.
Fourth, the price varies depending on the region. In the place where the chemical industry gathers, due to the scale effect, logistics is convenient, the cost is low, and the price may be slightly inferior to that in remote places.
In the current market, the price per gram may range from tens of yuan to hundreds of yuan. However, this is only an approximate number. The actual price depends on the specific quality, purity, as well as the season of buying and selling, the strategy of the merchant, and many other factors. To know the exact price, consult the chemical raw material supplier in detail and compare the quotations of various companies before you can get it.