2-Benzylaminopyridine, [N-Benzyl-2-pyridylamine

2-Benzylaminopyridine, [N-benzyl-2-pyridylamine] has a wide range of uses and is used in various fields such as chemical industry and medicine.
In the chemical industry, it is often used as a key intermediate in organic synthesis. Due to the unique structure of the pyridine ring and benzyl group, it can participate in a variety of chemical reactions, such as nucleophilic substitution and electrophilic substitution. By ingeniously designing the reaction path, many complex organic compounds can be synthesized, such as aromatic compounds with specific structures. In materials science, such compounds may contribute to the creation of new polymer materials and functional materials.
In the field of medicine, its importance cannot be underestimated. Studies have shown that compounds containing this structure may have certain biological activities. It may be used as a lead compound for medicinal chemists to further explore and modify in order to develop new drugs with better efficacy and less side effects. For example, after structural optimization, it may be used to develop inhibitors for specific disease targets, which is expected to provide new ideas for the treatment of difficult diseases.
In addition, in some catalytic reactions, 2-benzylaminopyridine may also play the role of a ligand, combining with metal ions to form a catalyst with unique properties, improving the selectivity and efficiency of the reaction, and helping the synthesis of fine chemicals to a new height.

2-Benzylaminopyridine, that is, [N-benzyl-2-pyridylamine], this material has the following physical properties:
Its appearance is mostly white to light yellow crystalline powder, and it looks like finely crushed jade chips, delicate and uniform. Under normal temperature and pressure, the properties are quite stable, just like a gentleman who is not alarmed by changes, and does not change easily due to external perturbations.
The melting point is between 59 and 62 ° C, just like ice melting at a specific temperature. In this temperature range, its solid state begins to gradually transform into a liquid state, and the shape changes, but the essence remains unchanged. The boiling point of
is about 204-206 ° C. When the temperature rises to this point, it boils like water in a river and turns into a gaseous state.
Slightly soluble in water, entering the water is like swimming fish into a shoal, and only a small amount can be dispersed in it. However, in organic solvents such as ethanol and chloroform, it is like a bird entering the forest, easily soluble, and fuses well with the solvent.
Its density is slightly larger than that of water, and it is thrown into the water, such as a stone sinking into the abyss, slowly settling. And it has a certain smell, smell it, and the smell is unique. Although it is not pungent, it is also clearly recognizable.
These physical properties are of great significance in many fields such as chemical engineering and medicine, and are related to their extraction, separation, and application. They are like strands of silk and beads, connecting many links in industrial production and scientific research.

There are several methods for the synthesis of 2-benzylaminopyridine, that is, [N-benzyl-2-pyridylamine]:
First, 2-chloropyridine and benzylamine are used as raw materials. Take an appropriate amount of 2-chloropyridine, place it in a reactor, add benzylamine, and dissolve it in an appropriate amount of organic solvent, such as toluene. Then add an appropriate amount of base, such as potassium carbonate, to promote the reaction. When heated to a suitable temperature, about 80-100 ° C, and the number of reactions is stirred. After the reaction is completed, the solvent is removed by vacuum distillation, and then separated and purified by column chromatography. The product can be obtained. This is because the chlorine atom of 2-chloropyridine is active and can undergo nucleophilic substitution reaction with benzylamine.
Second, 2-pyridyl boric acid and benzyl halide are used as raw materials. Add 2-pyridyl boric acid, benzyl halide (such as benzyl bromide), appropriate base (such as sodium carbonate) and palladium catalyst (such as tetra (triphenylphosphine) palladium) to an organic solvent (such as a mixture of dioxane and water). React at 80-100 ° C, with the help of palladium catalysis, and an arylation reaction occurs. After the reaction is completed, the product is obtained through extraction, drying, column chromatography and other steps. This method uses palladium-catalyzed cross-coupling reaction to efficiently construct carbon-nitrogen bonds.
Third, 2-aminopyridine and benzyl aldehyde are used as raw materials. In the reaction vessel, add 2-aminopyridine and benzyl aldehyde, and use an appropriate amount of acid as catalyst, such as p-toluenesulfonic acid. Add an appropriate amount of organic solvent, such as ethanol. Under the condition of heating and reflux, the imine intermediate is formed first, and then reduced by a reducing agent (such as sodium borohydride) to obtain 2-benzylaminopyridine. This process is synthesized by the condensation of aldehyde and amine and subsequent reduction reactions.

I look at what you are asking, it is 2-benzyl aminopyridine, that is, [N-benzyl-2-pyridylamine] in the market price range. However, the price of these substances often changes for many reasons, and it is difficult to determine its fixed number.
First, the price of raw materials, if the price of benzyl compounds, pyridines and other raw materials required for its preparation fluctuates, the price of 2-benzyl aminopyridine will also fluctuate. If the price of benzyl raw materials rises due to harvest and transportation obstacles in the place of origin, the price of this product will also increase.
Second, the method of production. If the product is produced by the best method, the cost may be reduced, and the price may be low; if the method is difficult and expensive, the price will tend to be higher.
Third, the trend of supply and demand. If there are many seekers in the market, but there are few producers, the price will rise; if the supply exceeds the demand, the price will tend to fall.
Fourth, the difference in quality. Those with high purity and excellent quality often have higher prices than ordinary ones.
According to past examples and market conditions, the price range may range from a few yuan per gram to tens of yuan. However, this is only a rough estimate. The actual price needs to be determined by consulting chemical product suppliers, traders, or referring to the latest quotations from professional chemical trading platforms.

The storage conditions of 2-benzylaminopyridine, [N-benzyl-2-pyridylamine], are crucial to the preservation and utility of this substance. This substance should be stored in a cool, dry and well-ventilated place.
Those who are in the shade should avoid baking at high temperatures. High temperatures can easily cause changes in its molecular structure or trigger chemical reactions, which can damage its purity and quality. For example, under the hot sun, everything is easy to dry. Similarly, high temperatures can make the chemical properties of 2-benzylaminopyridine unstable or even deteriorated.
Where it is dry, it can prevent it from getting wet. Water is the medium for many chemical reactions. If this substance is damp, moisture can promote its hydrolysis or other adverse reactions. For example, wood is perishable in water, and 2-benzylaminopyridine may also change its chemical properties in water, so it needs to be kept away from water vapor.
Well-ventilated places can disperse volatile gases that may accumulate. If stored in a closed, airless place, volatile gas accumulates, or the local concentration is too high, which not only affects the surrounding environment, but may also cause unexpected reactions due to concentration changes, endangering the storage safety of this substance.
In addition, storage should be separated from oxidants, acids and other substances. Oxidants are strong oxidizing, acids are corrosive, and contact with 2-benzylaminopyridine can easily induce violent chemical reactions, such as fire and dry firewood, which may lead to serious consequences such as combustion and explosion.
Storage containers also need to choose those with good corrosion resistance and sealing. Corrosive-resistant containers can prevent the material of the container from interacting with 2-benzylaminopyridine and causing it to deteriorate; good sealing can effectively block the intrusion of external water vapor, air and other factors to ensure stable storage conditions. In this way, 2-benzylaminopyridine can be properly preserved to make its properties stable and ready to play its due effect when needed.