2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)

This is an organic compound named 2 - [benzyl (methyl) amino] ethyl, methyl 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine - 3,5 - dicarboxylate, hydrochloride (1:1). Its chemical structure is as follows:
The main structure is a 1,4 - dihydropyridine ring, which is very important in the field of organic synthesis and pharmaceutical chemistry. There is a methyl group attached to the 2nd and 6th positions on the ring, which is symmetrically distributed, which increases the structural stability. The 4-position is connected with 3-nitrophenyl group, which affects the electron cloud distribution and reactivity of the compound. The nitro group is a strong electron-absorbing group, or changes the physicochemical properties and biological activities of the compound.
The 3-position and 5-position monocarboxylic acid ester groups, namely 2 - [benzyl (methyl) amino] ethyl, methyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate "dicarboxylate" part. Among them, the alcohol part of the carboxylic acid ester at the 3rd position is 2- [benzyl (methyl) amino] ethyl, and this long-chain structure introduces benzyl and methyl amino groups, or increases the fat solubility of the compound and its ability to interact with biological targets; the alcohol part of the carboxylic acid ester at the 5th position is methyl.
Furthermore, the compound is in the form of hydrochloride, that is, it forms a salt with hydrochloric acid, which can often change the solubility and stability of the compound, and is common in pharmaceutical preparations. Hydrochloride is formed or can form a salt with hydrogen ions in hydrochloric acid due to the presence of basic nitrogen atoms in the molecule.

This is a chemical substance named 2 - [benzyl (methyl) amino] ethyl, methyl 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine - 3,5 - dicarboxylate, hydrochloride (1:1). Its physical properties are as follows:
This substance is solid at room temperature, and its specific properties vary depending on purity and preparation process. Looking at its structure, it contains groups such as dihydropyridine ring, benzyl, methyl and nitrophenyl. These structures have a great influence on its physical properties.
In terms of melting point, due to the interaction between atoms and groups in the molecule, the intermolecular force is relatively strong, and the melting point is expected to be higher. The exact melting point needs to be determined experimentally, but the structural characteristics make it tend to have a higher melting point.
In terms of solubility, because it contains polar groups such as carboxyl esters and amino groups, it may have a certain solubility in polar solvents such as alcohols and ketones. The existence of hydrocarbon groups and nitrophenyl groups results in limited solubility in non-polar solvents such as alkanes. In water, it may have certain solubility due to the interaction of hydrogen bonds with water molecules, but due to the large molecule and some non-polar groups, the solubility may not be very high. < Br >
In terms of stability, the dihydropyridine ring is relatively active, and under specific conditions such as light, high temperature or strong acid and alkali environment, it may undergo a reaction to cause structural changes. Nitrophenyl groups have certain oxidizing properties and may participate in the reaction in specific chemical environments. However, when they are dry at room temperature and without the action of special chemical reagents, they are overall or relatively stable.
The physical properties of this chemical substance are speculated based on structural analysis, and accurate data need to be determined experimentally and carefully.

2 - [benzyl (methyl) amino] ethyl, methyl 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine - 3,5 - dicarboxylate, hydrochloride (1:1), although this drug is difficult to find in ancient texts, but from today's medical perspective, it is quite effective in the field of cardiovascular.
The structure of this substance is a dihydropyridine derivative. Many of these compounds have the ability to regulate cardiovascular function. This drug may act on calcium ion channels on cell membranes to regulate calcium ion influx. The normal contraction of the heart and vascular smooth muscle depends on the participation of calcium ions. If the calcium ion influx is abnormal, the cardiovascular function is easily disturbed.
This drug may block the calcium ion channel and make the calcium ion influx moderate, thereby relieving the vascular smooth muscle, making the blood vessels relax, reducing the peripheral vascular resistance, and achieving the effect of lowering blood pressure. In angina, vasodilation can increase coronary blood flow, improve myocardial blood supply, and relieve angina symptoms.
Furthermore, it may affect the electrophysiological activity of the heart, which can adjust the heart rate and make the heart rhythm return to normal. In arrhythmia, it may play a role in correcting the heart rhythm.
However, the use of drugs should be done with caution. It is necessary to weigh the advantages and disadvantages according to the specific condition, constitution and other factors of the patient, and use precise medication to achieve the best effect and avoid the harm of adverse reactions.

There are currently 2 - [benzyl (methyl) amino] ethyl, methyl 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine - 3,5 - dicarboxylate hydrochloride (1:1). To prepare it, the method is as follows.
First take an appropriate amount of 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine - 3,5 - dicarboxylic acid and place it in a clean reaction vessel. Add an appropriate amount of alcohol solvent, such as methanol, stir to dissolve it, and prepare a uniform solution. In this solution, a solution containing an appropriate amount of sulfoxide chloride is slowly added dropwise. The reaction temperature needs to be controlled during the dropwise addition process, and the temperature should not be too high to prevent side reactions from occurring. After the dropwise addition is completed, continue to stir to fully react for a period of time. This step aims to convert the carboxyl group into an acid chloride group.
After the reaction is completed, the excess sulfoxide chloride can be removed by vacuum distillation. Subsequently, the obtained acid chloride product is added to the reaction system containing 2 - [benzyl (methyl) amino] ethanol, and an appropriate amount of acid binding agent, such as triethylamine, is added at the same time to neutralize the hydrogen chloride generated by the reaction. This reaction needs to be carried out under suitable temperature and stirring conditions, so that the acid chloride and alcohol can be esterified smoothly to form the target product precursor.
Finally, the obtained precursor product is dissolved in an appropriate amount of organic solvent, and dry hydrogen chloride gas is introduced until the reaction system reaches the expected pH, so that the precursor is converted to 2 - [benzyl (methyl) amino] ethyl, methyl 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine - 3,5 - dicarboxylate hydrochloride (1:1). After the reaction is completed, a pure target product can be obtained through post-processing steps such as filtration, washing, and drying. During the entire synthesis process, attention should be paid to the precise control of reaction conditions, and the connection between each step must also be close, so as to improve the yield and purity of the product.

The name of this drug is 2 - [benzyl (methyl) amino] ethyl, methyl 2,6 - dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine - 3,5 - dicarboxylate hydrochloride (1:1). It is related to the safety of this drug, and the user should be cautious.
Before taking the drug, it is necessary to check your medical history carefully. If you have a history of cardiovascular disease, liver and kidney impairment or allergies, you must tell the doctor truthfully. Because it may affect the metabolism and reaction of the drug, a little carelessness will cause accidents. For example, in patients with hepatic and renal insufficiency, the excretion of drugs slows down, which can easily lead to accumulation in the body and increase the risk of adverse reactions.
In medication, it is essential to strictly follow the doctor's instructions. Do not change the dose and course of treatment without authorization to prevent ineffective or increased toxicity. This medicine may interact with other medicines, such as taking it with certain antihypertensive medicines, or causing a sudden drop in blood pressure. Therefore, before using other medicines, consult a doctor, and it can only be used if there is no hindrance.
At the same time, pay attention to your own reactions. If you have any abnormalities such as headache, dizziness, heart palpitations, and rashes, report to the doctor immediately. In light cases, the medication may be adjusted, and in severe cases, emergency treatment is required. Furthermore, pregnant women and breastfeeding women should The drug may endanger the fetus or infant through the placenta or milk. Do not use these two groups of people unless absolutely necessary. Only in this way can the safety of the drug be guaranteed, and the effect of the drug can be expected.