2-Aminopyridine-3-methanol

2-Aminopyridine-3-methanol is an organic compound with multiple chemical properties. It contains amino groups and hydroxymethyl groups, which can cause a variety of chemical reactions.
Bear the brunt, the amino group is basic, and the nitrogen atom has lone pairs of electrons, which can form salts with acids. In the case of strong acids such as hydrochloric acid, the amino group will accept protons and form corresponding salts. This property is used in organic synthesis to separate and purify the compound.
Furthermore, hydroxymethyl groups can participate in many reactions. One is oxidation, which can be oxidized to an aldehyde group or a carboxyl group by suitable oxidants, such as mild Dess-Martin oxidants or strong potassium permanganate. If the conditions are suitable, the hydroxymethyl group can be oxidized to an aldehyde group to obtain 2-aminopyridine-3-formaldehyde; if the oxidizing agent is stronger, the reaction conditions are more severe, or further oxidized to a carboxyl group, 2-aminopyridine-3-carboxylic acid can be obtained.
In addition, hydroxymethyl groups can also participate in the substitution reaction. Hydroxyl groups can be replaced when suitable nucleophiles are available. For example, under appropriate conditions, when reacting with halogenated hydrocarbons, the hydroxyl group is replaced by a halogenated atom to form a halogenated derivative. This derivative is often used as an important intermediate in the construction of carbon-carbon bonds or carbon-heterogeneous bonds, such as Suzuki coupling and Negishi coupling.
At the same time, the pyridine ring of 2-aminopyridine-3-methanol also has certain reactivity. The electron cloud distribution on the pyridine ring is uneven, the nitrogen atom makes the electron cloud density of the adjacent and para-sites relatively low, and the meta-site is relatively high, and the electrophilic substitution reaction is more likely to occur in the meta-site. For example, under suitable catalysts and conditions, electrophilic substitution reactions such as halogenation and nitrification can occur.
In addition, amino groups and pyridine rings can jointly participate in some cyclization reactions to construct more complex heterocyclic systems, providing novel structural compounds for organic synthesis, which may have potential applications in pharmaceutical chemistry, materials science and other fields. In conclusion, 2-aminopyridine-3-methanol is of great significance in organic synthesis and related fields due to its unique structure and rich chemical properties.

There are several common methods for the synthesis of 2-aminopyridine-3-methanol.
One is to use 2-amino-3-methylpyridine as the starting material. First, 2-amino-3-methylpyridine is oxidized, and suitable oxidants such as potassium permanganate or potassium dichromate can be selected. During this oxidation process, methyl groups are oxidized to carboxyl groups to obtain 2-amino-3-pyridine carboxylic acid. Subsequently, 2-aminopyridine-3-carboxylic acid is reduced by a strong reducing agent, such as lithium aluminum hydride, which can convert the carboxyl group into methanol group, and then successfully obtain 2-aminopyridine-3-methanol.
The second is to use 2-aminopyridine-3-carboxylate as the starting material. First, ethyl 2-aminopyridine-3-carboxylate is prepared by esterification with ethanol, concentrated sulfuric acid and other reagents. After that, 2-aminopyridine-3-carboxylate ethyl ester is reduced by a reducing agent, such as the combination of sodium borohydride and lithium chloride. The reaction can convert the ester group into methanol group to achieve the synthesis of 2-aminopyridine-3-methanol.
The third is to use 2-amino-3-halopyridine and formaldehyde as raw materials. First, 2-amino-3-halopyridine reacts with formaldehyde under the catalysis of bases, which can be sodium hydroxide, potassium hydroxide, etc. In the reaction, the halogen atom is replaced by hydroxymethyl to form the corresponding 2-amino-3- (hydroxymethyl) pyridine intermediate. Then, the intermediate is reduced, and suitable reducing agents, such as hydrogen and palladium-carbon catalyst system, can be selected to obtain 2-aminopyridine-3-methanol.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, yield and difficulty of post-treatment to choose the most suitable synthesis path.

2-Aminopyridine-3-methanol is useful in various fields. This compound has a great role in the development of medicine. Because of its unique chemical structure, it can be used as a key intermediate to create a variety of drugs. For example, it can be used to develop antimalarial drugs, which can inhibit or kill malaria parasites by its structure; or in the development of anticancer drugs, it can participate in the construction of active ingredients that interfere with the growth and division of cancer cells.
In the field of materials science, 2-aminopyridine-3-methanol can also be used. It can be used to prepare materials with specific functions, such as those with special optical or electrical properties. After ingenious design and synthesis, the material exhibits unique properties, which may play an important role in optoelectronic devices, sensors, etc. For example, sensors that are sensitive to specific substances can be constructed, and accurate detection can be achieved by virtue of their specific effects on the target.
Furthermore, in the field of organic synthesis, this compound is often used as a building block for organic synthesis. Because it contains amino and methanol groups, it can participate in many organic reactions, assisting chemists in constructing complex organic molecular structures. Through various reaction paths, a variety of organic compounds can be derived, expanding the boundaries of organic synthesis, and providing a rich material basis for the creation of new materials and new drugs.

At this time, it is really difficult to know the market price of 2-aminopyridine-3-methanol. This is because the market price is like a boat on a river, fluctuating with many factors. Its price is often affected by variables such as the abundance of raw materials, the situation of supply and demand, the difficulty of technology, and regional differences.
When it comes to raw materials, the amount and price of raw materials are directly related to the cost of this material. If raw materials are scarce, the price will rise, and the price of 2-aminopyridine-3-methanol will also rise. The same is true of supply and demand. If there are many applicants and few suppliers, the price will rise; conversely, if the supply exceeds the demand, the price will fall.
The difficulty of the process is also the key. If the preparation method is complicated, exquisite technology and expensive tools are required, and the cost increases, the price will also be high. Furthermore, the price varies depending on the region. The prosperous capital of Dayi, due to convenient logistics and strong demand, the price may be different from that of remote places.
Therefore, if you want to know the exact market price, you should carefully observe the dynamics of the chemical market, consult a merchant specializing in chemical materials, or check a professional chemical price information platform, in order to obtain a more accurate price to meet the needs.

2-Aminopyridine-3-methanol is an organic compound. Its storage conditions are crucial, which is related to the stability and quality of this compound.
If this compound is stored, the first thing is to keep it in a cool place away from light. Sun exposure, or cause the compound to undergo photochemical reactions, causing its structure to change and damaging its chemical properties. Therefore, it should be stored in a dark place, such as in a dark bottle, or in a cabinet without light.
Second, temperature is also critical. It should be stored in a low temperature environment, usually 2-8 ° C. High temperature may promote its decomposition or accelerate chemical reactions, reducing its shelf life. If left at room temperature for a long time, it may cause quality deterioration.
Furthermore, the storage environment needs to be kept dry. Moisture may react with the compound, causing adverse consequences such as hydrolysis. Therefore, it can be stored and disposed of as a desiccant to absorb moisture from the environment and keep it dry.
In addition, this compound may have certain toxicity and irritation, and it must be properly sealed when stored. To prevent leakage, endanger personnel safety, and avoid its reaction with air components.
In short, the storage of 2-aminopyridine-3-methanol needs to be protected from light, low temperature, dry and sealed, so as to maintain its chemical stability and extend its service life.