2-Aminopyridine-3-carboxyaldehyde

2-Aminopyridine-3-formaldehyde, which has a wide range of uses. In the field of medicine, it is a key intermediate. Due to the synthesis of medicine, it often requires delicate construction of molecular structures. Its special chemical structure can participate in various reactions and help synthesize many compounds with biological activities, such as specific antibacterial drugs, drugs for treating neurological diseases, etc.
In the field of materials science, it also has important value. It can be used to prepare functional materials. By reacting with other substances, it can give materials unique properties, such as improving the optical and electrical properties of materials, or enhancing their stability and durability. It is widely used in the research and development of new optoelectronic devices and sensor materials.
In addition, in the field of organic synthetic chemistry, 2-aminopyridine-3-formaldehyde is often used as a starting material or reaction intermediate. Due to the activity of amino and aldehyde groups, it can initiate and guide the construction of complex organic molecules. Chemists can use this to design and synthesize organic compounds with novel structures and specific functions, promoting the progress and development of organic synthetic chemistry.

The method for synthesizing 2-aminopyridine-3-formaldehyde is now your way. There are many methods, and the common ones have several ends.
First, the pyridine compound is used as the starting material. If a suitable pyridine derivative is selected, the amino group is introduced at a specific position first, and then the aldehyde group is introduced at the ortho position through a suitable oxidation step. Specifically, a pyridine with a suitable substituent can be found, and the amino group can be connected to the target check point by a reaction such as nucleophilic substitution. Subsequently, with a suitable oxidizing agent, such as a mild oxidizing agent, the ortho group is converted into an aldehyde group. This process requires precise control of reaction conditions, such as temperature, reaction time, reagent dosage, etc., to prevent excessive oxidation or side reactions.
Second, the construction of nitrogen-containing heterocycles can be started. With specific nitrogen-containing raw materials, pyridine rings are constructed through cyclization, and amino and aldehyde groups are introduced into the rings at the same time. This approach requires clever design of the reaction route, selection of suitable starting materials, so that the cyclization reaction can occur as expected, and precise positioning of amino and aldehyde groups. In the reaction, the choice of solvent and the addition of catalyst have a significant impact on the reaction process and product purity.
Third, metal-catalyzed coupling reactions can also be used. Halogenated pyridine or borate esters with specific substituents are selected, and under the catalysis of metal catalysts such as palladium and copper, they are coupled with reagents containing amino groups and aldehyde precursors. Such reaction conditions are relatively mild and the selectivity is good, but the catalyst cost is high, and the post-reaction treatment may require complicated operations to remove metal residues, so as not to affect the quality of the product.
All these synthesis methods have advantages and disadvantages. In practice, it is necessary to carefully choose according to the availability of raw materials, cost considerations, product purity requirements and many other factors in order to obtain satisfactory synthesis results.

2-Aminopyridine-3-formaldehyde is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
Looking at its properties, under normal temperature and pressure, it often appears as a solid state. This state is stable, laying the foundation for its application. As for the color, it is mostly white to light yellow, and this color characteristic may help to distinguish this substance.
When it comes to the melting point, the melting point of this compound is about 144-146 ° C. The melting point, the temperature limit at which a substance changes from a solid state to a liquid state, is of great significance for the study of its state change during heating.
Solubility is also a key property. 2-Aminopyridine-3-formaldehyde exhibits good solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). However, in water, the solubility is relatively limited. This property determines its application scenarios in different solvent systems. In organic synthesis, a suitable solvent can be selected according to its solubility to achieve the best reaction effect.
In addition, the density of this substance also has its specific value. Although the exact density value varies slightly due to measurement conditions, the density is about 1.3g/cm ³. Density, as an inherent property of a substance, is an important consideration in the fields of material preparation and product design.
In summary, the physical properties of 2-aminopyridine-3-formaldehyde, such as properties, color, melting point, solubility, and density, are interrelated and play an indispensable role in chemical research and practical applications, providing an important basis for in-depth exploration of its chemical behavior and application value.

2-Aminopyridine-3-formaldehyde is an organic compound with multiple chemical properties, which is essential in the field of organic synthesis.
It bears the brunt, containing two active functional groups of amino and aldehyde groups. The amino group is basic and can react with acids to form corresponding salts. Under specific conditions, amino groups can also participate in nucleophilic substitution reactions, combining with electrophilic reagents such as halogenated hydrocarbons to expand the structure of molecules.
Furthermore, the activity of aldehyde groups should not be underestimated. The aldehyde group can undergo oxidation reaction. After being treated with weak oxidants such as Torun reagent or Feilin reagent, the aldehyde group will be oxidized to a carboxyl group. This property is often used in the identification and qualitative analysis of aldehyde compounds. At the same time, aldehyde groups can also undergo reduction reactions, and are converted into alcohol hydroxyl groups under the action of reducing agents, which enriches the chemical conversion pathways of compounds.
Especially important, aldehyde groups can participate in classic condensation reactions, such as with compounds containing active hydrogen, such as ketones and esters, under alkali catalysis, hydroxyl aldehyde condensation reactions occur to form carbon-carbon double bonds, providing an effective means for the growth of carbon chains and the construction of complex structures in organic synthesis.
In addition, the pyridine ring of 2-aminopyridine-3-formaldehyde has aromatic properties, which endows the molecule with certain stability. The nitrogen atom on the pyridine ring can provide lone pairs of electrons to participate in coordination chemistry and form complexes with metal ions, which shows potential application value in the field of materials science and catalysis.
In summary, 2-aminopyridine-3-formaldehyde plays a key role in many fields such as medicinal chemistry, materials science and fine chemistry due to its unique structure and diverse chemical properties, providing an indispensable basic raw material for organic synthesis chemists to create novel compounds and materials.

The price of 2-aminopyridine-3-formaldehyde in the market is difficult to determine. There are three reasons for this: First, the purity of this compound is different. Those with high purity are expensive, and those with more impurities are slightly cheaper. Second, the purchase quantity is also the key. If you buy it in bulk, you can often get a preferential price; if you buy it in small quantities, the unit price may be higher. Third, the supply and demand situation of the market also affects its price. If you need more supply and less supply, the price will increase; if supply exceeds demand, the price may drop.
According to the previous "Tiangong Kaiwu", the price of the product often varies due to various factors, and this 2-aminopyridine-3-formaldehyde is no exception. In today's market, if the purity is excellent, if you buy it in small quantities, the price per gram may be in the tens of yuan. If it is industrial grade and the purchase volume is quite large, such as kilogram grade, the price per kilogram may be in the hundreds of yuan. However, this is only a rough estimate, and the actual price depends on the current market conditions, the supplier's asking price, etc. To know the exact price, you need to consult the chemical raw material supplier and compare it with its quotation to get a more accurate price.