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2- (Aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride 97% What is the main application field?
2-%28Aminomethyl%29-3-chloro-5-%28trifluoromethyl%29pyridine hydrochloride is 97%, that is, 97% pure 2- (aminomethyl) - 3-chloro-5- (trifluoromethyl) pyridine hydrochloride, which has a wide range of uses.
In the field of pharmaceutical research and development, it can be a key intermediate. Geinpyridine compounds are quite common in the molecular structure of drugs and have a variety of biological activities. This compound contains functional groups such as chlorine, trifluoromethyl and aminomethyl. It can be linked to other groups by organic synthesis to create new compounds with specific pharmacological activities, such as drugs such as inhibitors or agonists targeting specific disease targets.
In the field of pesticide creation, it also plays an important role. Pyridine derivatives have many applications in the field of pesticides, or have the functions of bactericidal, insecticidal, herbicidal, etc. This compound has a unique structure and can be used as a lead compound. After structural modification and optimization, new pesticides with high efficiency, low toxicity and environmental friendliness can be developed. For example, by adjusting its substituents, the effect on specific pests or pathogens can be enhanced, providing strong support for the pest control of agricultural production.
In the field of materials science, because it contains special functional groups, or can participate in the synthesis of specific materials. For example, in the preparation of some functional polymer materials, as functional monomers, the materials are endowed with special properties such as fluorescence and conductivity, expanding the application of materials in the field of optoelectronics.
In summary, 2- (aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride has important potential applications in the fields of medicine, pesticides, and materials science, and is of great significance for promoting technological progress in related industries.
What is the market price range for 2- (Aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride 97%?
What I'm asking you is about the market price range of 97% for 2- (aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride. However, the price of such chemicals often varies due to many factors, and it is difficult to hide it.
The first to bear the brunt is the trend of supply and demand. If the demand for this chemical is strong and the supply is limited, the price will increase; conversely, if the market supply is abundant and the demand is weak, the price may drop. Second, the price of raw materials also has an impact. The fluctuation of the price of raw materials required to produce this chemical is directly related to the cost of the finished product, which in turn affects the price. Furthermore, the difficulty of production and the simplicity of the process are also variables of price. If the preparation process requires superb skills and complex processes, the cost will increase, and the price will follow.
As for the specific price range, based on past examples, it may range from tens to hundreds of yuan per gram. However, this is only a rough figure, and the actual price depends on the current market situation, the volume of transactions and the specific circumstances of the transaction. Or you can consult the chemical raw material supplier, or visit the relevant chemical trading platform to get a more accurate price.
2- (Aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride 97% quality control standards
2-%28Aminomethyl%29-3-chloro-5-%28trifluoromethyl%29pyridine hydrochloride 97%, that is, 2 - (aminomethyl) -3 - chloro - 5 - (trifluoromethyl) pyridine hydrochloride, its quality control standard is very critical.
In terms of appearance, white to off-white crystalline powder is often preferred. If the color is dull, there is obvious variegation or agglomeration, it may affect the quality of the product. This appearance characteristic is similar to the purity and flawlessness of beautiful jade, which is the first characteristic of quality.
Content determination is crucial. According to high-performance liquid chromatography (HPLC), the content of the main component must reach 97.0% and above. This measurement is like a precise measurement, which is the core indicator to determine whether the product is qualified. Just like marching and fighting a war, sufficient grain and grass (content up to standard) can ensure victory.
Related substances cannot be ignored. By HPLC detection of specific impurities, each single impurity should not exceed 1.0%, and the total impurity should not exceed 3.0%. Impurities such as hidden enemies, although small, can affect the overall situation. Strict control of impurities can ensure product purity.
Drying weight loss is usually not more than 0.5%. Too much moisture will damage the stability of the product, just like the cornerstone of the house is eroded by water, and the stability cannot be discussed. Burning residue is generally not more than 0.1%. This is the control of residual impurities after high temperature burning of the product, reflecting the purity of the product.
The content of heavy metals shall not exceed 20 parts per million in terms of lead. If the heavy metals exceed the standard, they will be mixed in like poisons, which is extremely harmful and must be strictly limited.
The above quality control standards complement each other and are indispensable. Together, they ensure the quality of 2- (aminomethyl) -3 -chloro-5- (trifluoromethyl) pyridine hydrochloride, so that it can play its due role in many fields.
2- (Aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride 97% production process
2 - (aminomethyl) - 3 - chloro - 5 - (trifluoromethyl) pyridine hydrochloride, the content is 97%, and the preparation process is as follows:
The starting material selects a compound containing a pyridine structure. This compound needs to contain a transformable group at a specific position in the pyridine ring, such as a halogen atom or other active substituent, to lay the foundation for the subsequent introduction of the target substituent.
First, the aminomethylation reaction is carried out, and a suitable aminomethylation reagent, such as a mixed system of formaldehyde and ammonia or other equivalent reagents, is used under suitable reaction conditions, such as specific temperature, pressure and catalyst, to interact with the starting pyridine compound. This process requires fine regulation of the reaction conditions. Due to too high or too low temperature and improper reagent ratio, side reactions may occur, affecting the purity and yield of the product. For example, too high temperature may cause excessive ammonia methylation and generate unnecessary multiple substituted products; if the temperature is too low, the reaction rate will be slow and time-consuming.
After the successful introduction of aminomethyl, the chlorination reaction will be carried out. Select suitable chlorination reagents, such as chlorine gas, sulfoxide chloride, etc., and select suitable chlorination methods according to the characteristics of the reaction substrate and the reaction environment. If the substrate is sensitive to the reaction conditions, or mild chlorination reagents and conditions are required to prevent other groups of the pyridine ring from being affected. This step also requires strict control of the reaction process. With the help of thin-layer chromatography, gas chromatography and other analytical methods, the degree of reaction is monitored to ensure that the chlorine atoms are accurately replaced to the target position.
Then, the trifluoromethylation step is carried out. Commonly used trifluoromethylation reagents, such as trifluoromethyl halides or metal-organic reagents with trifluoromethyl, react with the products of the previous two steps under catalysts and specific reaction conditions. This reaction condition requires strict conditions. Due to the high activity of trifluoromethylation reagents, the requirements for anhydrous and oxygen-free reaction environments are quite high, otherwise it is easy to cause side reactions and reduce the quality of the products.
After the above series of reactions, the products may contain impurities and need to be purified. Methods commonly used include recrystallization, column chromatography, etc. During recrystallization, a suitable solvent is selected to dissolve the product in a hot solvent, and pure crystals are precipitated after cooling; column chromatography is based on the different distribution coefficients of the product and impurities in the stationary and mobile phases to achieve separation.
Finally, the purified product is reacted with hydrochloric acid to form a salt to obtain 2- (aminomethyl) -3 -chloro-5- (trifluoromethyl) pyridine hydrochloride, and then dried and other post-treatment processes to obtain a target product with a content of 97%. The whole preparation process requires precise control of the reaction conditions at each step, and detailed analysis and monitoring of the product to ensure high purity and high yield of the product.
2- (Aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride 97% What are the precautions for storage and transportation?
2 - (aminomethyl) - 3 - chloro - 5 - (trifluoromethyl) pyridine hydrochloride, the content is 97%. This chemical substance has several important items to pay attention to when storing and transporting.
Let's talk about storage first. This chemical substance should be placed in a cool, dry and well-ventilated place. A cool place can avoid changes in its properties due to excessive temperature. If it is placed in a warm place, it may cause chemical reactions that damage its purity and even cause danger. Drying is also critical because it is resistant to moisture, moisture attack, or hydrolysis of the substance, which loses its inherent characteristics. And in a well-ventilated place, harmful gases can be avoided from accumulating. If the storage space is closed, once the substance evaporates a little gas, it will add up to a lot, or it may be a safety hazard.
As for transportation, be sure to ensure that the packaging is tight. This is to prevent it from leaking. Once it leaks, it will be harmful to the transportation environment and transportation personnel. And during transportation, avoid it from being mixed with other substances that may react. If it coexists with incompatible objects, the traffic will be bumpy, or it will cause a violent reaction, and the consequences will be unimaginable. The means of transportation also need to be kept clean and dry. If other contaminants are stored, the quality of the chemical may be affected. The transportation temperature should also be controlled, and relevant standards should be followed. It should not be too high or too low, so as to ensure the safety and quality of 2- (aminomethyl) -3-chloro-5- (trifluoromethyl) pyridine hydrochloride during transportation and storage.