2 Amino 6 Trifluoromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2-amino-6-trifluoromethyl pyridine

    Specifications

    HS Code

    727117

    Chemical Formula C6H5F3N2
    Molecular Weight 162.11
    Appearance Solid (Typical)
    Melting Point Data needed
    Boiling Point Data needed
    Density Data needed
    Solubility In Water Data needed
    Solubility In Organic Solvents Data needed
    Pka Value Data needed
    Flash Point Data needed
    Refractive Index Data needed

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    Frequently Asked Questions

    As a leading 2-amino-6-trifluoromethyl pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-amino-6-trifluoromethylpyridine?
    2-% Amino-6-trifluoromethylpyridine is an important organic compound with critical uses in many fields.
    In the field of medicine, it is often a key intermediate for the synthesis of various drugs. Due to its specific chemical structure, it can endow drugs with unique biological activities and pharmacological properties. By modifying and modifying its structure, new drugs with high efficiency and low toxicity can be developed to treat various diseases such as cardiovascular diseases, neurological diseases, tumors, etc. For example, the synthesis of some anti-cancer drugs relies on 2-% amino-6-trifluoromethylpyridine as the starting material, and an effective structure that interacts with cancer cells is constructed through multi-step reactions.
    In the field of pesticides, this compound also occupies an important position. The pesticides synthesized on this basis have high-efficiency insecticidal, bactericidal or herbicidal activities. Its special chemical structure allows it to precisely act on the specific physiological processes of the target organism, interfering with its normal growth and reproduction, thus achieving good control effects. And because it is relatively friendly to the environment and has low residues, it is in line with the current trend of green pesticide development.
    In the field of materials science, 2-% amino-6-trifluoromethylpyridine can participate in the preparation of special polymer materials. Because its functional groups can react with other monomers, it endows the material with special physical and chemical properties, such as improving the thermal stability, mechanical properties, and optical properties of the material. The preparation of some high-performance engineering plastics and optoelectronic materials will also use this compound to expand the application range of materials and play an important role in high-end fields such as electronics and aerospace.
    What are the synthesis methods of 2-amino-6-trifluoromethylpyridine?
    To prepare 2-amino-6-trifluoromethylpyridine, the method is as follows:
    First, start with 2-chloro-6-trifluoromethylpyridine and react with ammonia under a specific catalyst and suitable temperature and pressure. In this reaction, the chlorine atom is replaced by an amino group to obtain the target product. The key to this process is to select a suitable catalyst, which can promote the reaction to proceed quickly and increase the yield and purity of the product. Usually metal salts or supported metal catalysts can be selected. The reaction temperature should be controlled in a certain range, and the pressure needs to be precisely adjusted to make the reaction proceed towards the formation of the target product.
    Second, using suitable pyridine derivatives as raw materials, the target structure is constructed through multi-step reaction. First, a specific substituent is introduced on the pyridine ring, and then the functional group is converted and modified to gradually reach the structure of 2-amino-6-trifluoromethyl pyridine. For example, a group that can be converted into an amino group is first introduced, and then it is converted into an amino group by reduction and other reactions, and trifluoromethyl is introduced at the same time. This process requires fine regulation of the reaction conditions according to the reaction characteristics of each step to ensure the smooth and efficient reaction of each step.
    Third, there are also nitrogen-containing heterocyclic compounds and reagents containing trifluoromethyl as starting materials, which are cyclized to form a pyridine ring, and amino groups and trifluoromethyl are introduced at the same time. This approach requires the design of an ingenious reaction route, using the activity and selectivity of the reactants to cyclize and replace the reaction in the expected manner to generate the target 2-amino-6-trifluoromethylpyridine. During operation, factors such as reaction solvent, temperature, catalyst, etc. should be carefully considered to optimize the reaction process and product quality.
    What are the physical and chemical properties of 2-amino-6-trifluoromethylpyridine?
    2-Amino-6-trifluoromethyl pyridine is a crucial intermediate in organic synthesis and is widely used in many fields such as medicine, pesticides, and materials. Its physical and chemical properties are as follows:
    Looking at its properties, under normal temperature and pressure, 2-amino-6-trifluoromethyl pyridine usually appears as a colorless to light yellow liquid or solid, which is closely related to its molecular structure and intermolecular interaction forces. In terms of melting point and boiling point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. The melting boiling point characteristics are affected by intramolecular hydrogen bonds and the electronegativity of fluorine atoms. The strong electronegativity of fluorine atoms enhances the intermolecular forces, resulting in changes in the melting boiling point.
    When it comes to solubility, the substance is soluble in common organic solvents such as ethanol, ether, dichloromethane, etc., but insoluble in water. This difference in solubility is due to its molecular structure, the pyridine ring and the amino group have a certain polarity, while the trifluoromethyl group is a non-polar group. As a whole, it is similar to the molecular force of the organic solvent, and follows the principle of "similar miscibility".
    In terms of stability, 2-amino-6-trifluoromethyl pyridine is relatively stable under conventional conditions, but it may cause combustion in the event of an open flame or hot topic, because it contains organic groups and is flammable. In addition, it can react violently with strong oxidizing agents, because the amino group has a certain degree of reductivity and is easily oxidized.
    Its acidity and alkalinity are also worthy of attention. Amino groups can bind protons, showing weak alkalinity, and can react with acids under specific conditions to generate corresponding salts.
    In terms of spectral properties, in infrared spectroscopy, amino groups will produce characteristic absorption peaks at specific wavenumbers, and pyridine rings also have corresponding characteristic absorption, which can be used to identify their structures. In hydrogen nuclear magnetic resonance spectroscopy, hydrogen atoms in different chemical environments will peak at corresponding chemical shifts, which can determine the type and number of hydrogen atoms, providing a strong basis for structural analysis.
    What is the price of 2-amino-6-trifluoromethylpyridine in the market?
    Today there is dihydroxyhexatriethylaminopyridine, what is the price in the market? This is a rare thing, and the price depends on various reasons.
    First, it is difficult to produce. If its preparation requires complicated methods, the materials used are rare, time-consuming and laborious, and the price will be high. If you want to make this product, or involve fine chemical synthesis, the environment and technical requirements are strict, so the cost will be high, and the price will also rise.
    Second, how much to ask for. If it is widely used in fields such as medicine and chemical industry, there will be many applicants, and the price will also increase. For example, in pharmaceutical research and development, if this substance is a key intermediate, pharmaceutical companies will compete for it, which will lead to higher prices.
    Third, the advantages and disadvantages of quality. Those with high purity and good quality will naturally have a higher price than usual. Less impurities, stable performance, and greater value to users. Willing to pay a high price to get it.
    Fourth, the status of supply. If there are many producers and sufficient output, the price may stabilize or decrease; if there are few producers, the supply is limited, and the price is easy to rise.
    In today's city, this dihydroxyhexatriethylamine pyridine, if the demand is greater than the supply, is difficult to prepare, and its price may be high, reaching hundreds of gold per gram, or even higher. If the market competition is intense, the preparation is gradually easy, and the price may decrease slightly, but it also fluctuates between tens of gold and hundreds of gold depending on the quality. Market conditions are volatile, and prices vary with supply, demand, and cost, making it difficult to determine a fixed price.
    What are the storage conditions for 2-amino-6-trifluoromethylpyridine?
    The storage conditions of 2-% hydroxy-6-trifluoromethylpyridine are crucial to the maintenance of its quality and utility.
    This compound should be placed in a cool, dry and well-ventilated place. A cool environment can protect it from the disturbance of high temperature, which often causes changes in the internal structure of the compound, or the risk of decomposition and deterioration. In a dry state, it can avoid moisture. If moisture is involved, it may induce chemical reactions such as hydrolysis, which will damage its purity and activity. Good ventilation can disperse volatile substances that may accumulate and maintain the stability of its chemical environment.
    Furthermore, it must be kept away from fire and heat sources. Pyridine compounds are flammable. When exposed to open flames and hot topics, they can easily cause combustion or even explode, endangering safety. At the same time, they should be stored separately from oxidants and acids. The structural characteristics of pyridine make it easy to oxidize with oxidants, and contact with acids may also trigger violent chemical reactions, which will cause the compound to deteriorate.
    The container for storing this substance should also be carefully selected. A container with good sealing performance should be used to prevent it from evaporating or reacting with external air components. And the container material should be compatible with the compound and not chemically react with it to ensure its stability during storage. Only in this way can 2-hydroxy-6-trifluoromethylpyridine be properly stored, so that it can retain good chemical properties and application efficiency in subsequent use.