2-Amino-6-phenylpyridine

2-Amino-6-phenylpyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. Due to its unique chemical structure, it endows molecules with specific activities and properties, and can participate in a variety of chemical reactions to build complex compounds with therapeutic effects.
In the field of materials science, it is also important. Or it can be used to prepare materials with special optoelectronic properties, such as organic Light Emitting Diode (OLED) materials. Because its structure can affect the electronic transport and luminescence properties of materials, it helps to improve the performance of OLED devices, such as luminous efficiency and stability.
In pesticide chemistry, it is also indispensable. It can be used as a raw material for the synthesis of new pesticides. After rational molecular design and modification, high-efficiency, low-toxicity and environmentally friendly pesticide varieties can be created to help agriculture control pests and diseases, and ensure crop yield and quality.
Furthermore, in the field of organic synthetic chemistry, 2-amino-6-phenylpyridine can be used as a multi-functional synthetic building block. Chemists can use its reaction with various reagents to construct rich and diverse organic molecular structures, expand the types and functions of organic compounds, and promote the development and innovation of organic synthetic chemistry.

2 - Amino - 6 - phenylpyridine is an organic compound with unique physical properties. It is a solid, stable at room temperature and pressure, and can be stored for a long time under specific conditions. Looking at its color, it is often white to light yellow powder, pure ones are light in color, and impurities are slightly darker in color. This color characteristic can be used as a reference when identifying.
When it comes to the melting point, it is about 105 - 108 ° C. This value is crucial and can be used to identify its purity. If the purity is high, the melting point is close to the theoretical value. If it contains impurities, the melting point may drop and the melting range becomes wider.
In terms of solubility, it has certain solubility in organic solvents such as ethanol and dichloromethane. The polarity of ethanol is consistent with the molecular structure of 2-Amino-6-phenylpyridine, and it can be dissolved by the intermolecular force; although the polarity of dichloromethane is weak, it can form a specific interaction with the compound. However, the solubility in water is poor. Due to the strong polarity of water, the force of interaction with 2-Amino-6-phenylpyridine molecules is weak, and it is difficult to overcome the attractive force between molecules to disperse it.
Furthermore, it has a certain sublimation property. At a specific temperature and pressure, it can be directly converted to a gaseous state by liquid state. This property may be applied in separation and purification. And it has a weak smell, and it has a special aromatic smell when smelled. However, the smell is weak, and it needs to be close to a fine smell to detect it. The density of
is higher than that of water, so it will sink underwater in an insoluble system. This property needs to be considered when involving liquid-liquid separation operations. In addition, the compound is sensitive to light and heat. It should be stored in a cool and dark place under long-term light or high temperature, or chemical reactions cause structural and property changes.

The chemical properties of 2-amino-6-phenylpyridine are quite stable. In its molecular structure, amino groups are linked to pyridine rings and phenyl groups to form a unique chemical structure.
From the perspective of reactivity, the presence of amino groups imparts a certain alkalinity to this compound, which can react with acids to generate corresponding salts. However, its reactivity is not very high. Under normal circumstances, without specific reaction conditions, such as suitable temperatures and catalysts, the reaction is difficult to occur spontaneously.
Pyridine rings are aromatic, which makes the whole molecule have a certain stability. The electron cloud of the aromatic system is uniformly distributed, which enhances the conjugation effect of the molecule, thereby reducing the energy of the molecule and making the structure more stable. The introduction of
phenyl groups also contributes to its stability. The steric hindrance effect of phenyl groups can hinder the attack of external reagents on the pyridine ring and amino groups to a certain extent, further maintaining the stable state of the molecule.
Furthermore, the chemical stability of 2-amino-6-phenylpyridine is also reflected in various organic solvents. In common organic solvents, such as ethanol and dichloromethane, the solubility is moderate, and the molecular structure is not easily changed during the dissolution process, which can maintain a relatively stable state.
In summary, 2-amino-6-phenylpyridine is chemically stable under normal conditions due to its special molecular structure, and it is not prone to violent chemical reactions.

The synthesis method of 2-amino-6-phenylpyridine, although not directly recorded in ancient books, can be deduced according to today's organic synthesis theory, referring to the ideas of ancient methods.
First, it can be prepared by substitution reaction of pyridine derivatives. Take suitable pyridine halides as starting materials, such as 2-halo-6-phenylpyridine, and react with ammonia under suitable conditions. The ammonia source can be ammonia, ammonia water or organic amines. If ammonia gas is used as the ammonia source, in a closed container at high temperature and pressure, 2-halo-6-phenylpyridine is co-heated with ammonia gas, and the halogen atom can be replaced by an amino group to obtain 2-amino-6-phenylpyridine. The reaction mechanism is nucleophilic substitution, and the halogen atom has a certain departure property. The nitrogen atom of ammonia is rich in electrons. Nucleophilic attacks the carbon atom connected to the halogen atom, and the halogen ion leaves, and then becomes the target product.
Second, synthesized by arylation reaction. Take 2-aminopyridine first and react with the phenylation reagent. Commonly used phenylation reagents such as phenylboronic acid and its esters are arylated in the presence of transition metal catalysts (such as palladium catalysts) and bases. Bases can help activate the catalyst and promote the reaction. This reaction condition is relatively mild and has good selectivity. During the process, palladium catalysts form active intermediates with phenylboronic acid, which are coupled with 2-aminopyridine to form carbon-carbon bonds to achieve the synthesis of 2-amino-6-phenylpyridine.
Third, the method of constructing nitrogen-containing heterocycles can also be used. Select appropriate nitrogen-containing and benzene-containing small molecules to construct pyridine rings through multi-step reactions. For example, using phenylacetonitrile and glyoxal as raw materials, through a series of reactions such as condensation and cyclization, the pyridine ring skeleton is first formed, and then the amino group is introduced through the amination step. During the condensation reaction, phenylacetonitrile and glyoxal undergo nucleophilic addition under alkali catalysis, and then cyclize to form a pyridine ring, and then use suitable amination reagents, such as hydroxylamine derivatives, to introduce amino groups through substitution reactions to obtain 2-amino-6-phenylpyridine.

In today's world, it is not easy to know the price of 2 - Amino - 6 - phenylpyridine in the market. The market conditions are changing rapidly, and the price of this product often varies depending on quality, origin, supply and demand.
When Tiangong Kaiwu was written in the past, although it was detailed in all kinds of process products, chemical products at that time were not as numerous as they are today. 2 - Amino - 6 - phenylpyridine and the like may not be included in the scope of his book.
If you want to get this price today, you can go to the market of chemical raw materials, or consult the suppliers of chemical products. They often know the market situation and know the price of this product. Or on the online business platform, search for its price widely and compare it comprehensively to get a more accurate number.
In addition, the price of chemical raw materials is often determined by many factors. If the production of this product is trapped by technology and raw materials, and the amount produced is small, and there are many who need it, the price will be high. On the contrary, if the production is convenient, the quantity is large and the demand is small, and the price may be lower. Therefore, if you want to know the price of the market, you must look at the current situation and observe all the reasons in detail to get a more realistic price.