2-Amino-6-chloropyridine

2-Amino-6-chloropyridine has a wide range of uses. In the field of pharmaceutical synthesis, it is an important intermediate. It covers the preparation of many drugs and relies on its participation in reactions to help form key structures. For example, the specific functional groups of some antibacterial drugs, 2-amino-6-chloropyridine can be combined with other compounds according to a specific mechanism to construct a molecular structure with antibacterial activity, making outstanding contributions to pharmaceutical research and development.
It is also indispensable in the creation of pesticides. It can be converted into pesticide active ingredients through a series of reactions, and by virtue of its structural characteristics, it can repel and poison specific pests, or play a role in plant growth regulation to ensure the healthy growth of crops and improve the quality and quantity of agricultural products.
In the field of materials science, 2-amino-6-chloropyridine has also emerged. It can participate in the synthesis of polymer materials, and by virtue of its unique chemical properties, adjust the properties of materials, such as improving the stability and mechanical properties of materials, expand the application scope of materials, and occupy an important position in the research and development process of new materials.
Overall, 2-amino-6-chloropyridine has important uses in many fields such as medicine, pesticides, and materials science, providing key support for the development of many industries and promoting continuous technological innovation and progress in related fields.

2-Amino-6-chloropyridine is one of the organic compounds. Its physical properties are quite specific and have many characteristics, which are described in detail below.
When it comes to appearance, 2-amino-6-chloropyridine is usually white to light yellow crystalline powder. The performance of this color state is quite recognizable among chemical substances, which can be one of the important characteristics for identifying this substance.
Its melting point is also a key physical property. After many experiments, the melting point of this compound is about 114-118 ° C. The stable range of the melting point reflects the stability and order of its molecular structure. When the temperature rises to the melting point range, 2-amino-6-chloropyridine gradually changes from solid state to liquid state, and this phase transition process is an important manifestation of its physical properties.
As for solubility, 2-amino-6-chloropyridine has relatively limited solubility in water, but it exhibits better solubility in organic solvents such as ethanol, acetone, dichloromethane, etc. This property is due to the interaction between its molecular structure and solvent molecules. The molecular structure of organic solvents is more compatible with 2-amino-6-chloropyridine, which can be dissolved through intermolecular forces such as van der Waals forces and hydrogen bonds.
Furthermore, the density of 2-amino-6-chloropyridine is also part of its physical properties. Although the exact value may vary slightly due to measurement conditions, the approximate density is within a specific range. The density value reflects the mass of the substance per unit volume and is related to the degree of molecular accumulation.
The vapor pressure of 2-amino-6-chloropyridine is low, which means that under normal temperature and pressure, it has a small tendency to volatilize. This property is crucial during storage and use. Because it is not easy to volatilize, it can be stored relatively stably in a specific environment. The physical properties of 2-amino-6-chloropyridine, such as its appearance, melting point, solubility, density, and vapor pressure, are inherent characteristics. These properties not only help to identify and identify it, but also play a key role in its application in chemical, pharmaceutical, and other fields, providing an important basis for research and practice in related fields.

The synthesis method of 2-amino-6-chloropyridine has been explored by many parties throughout the ages. One common method is to use 2,6-dichloropyridine as the starting material. Place 2,6-dichloropyridine in a suitable reaction vessel, add liquid ammonia as an amination reagent, and add an appropriate amount of catalyst, such as potassium carbonate. Under certain pressure and temperature conditions, it is fully reacted. During this process, the amino group of liquid ammonia will gradually replace one chlorine atom in 2,6-dichloropyridine, resulting in 2-amino-6-chloropyridine. The temperature control is quite critical, generally it needs to be maintained at a certain range. If it is too high, the side reactions will increase, and if it is too low, the reaction rate will be delayed.
The second method is to use 6-chloronicotinic acid as the starting material. First, 6-chloronicotinic acid is esterified to obtain 6-chloronicotinate. After that, 6-chloronicotinic acid is reacted with hydrazine to form 6-chloronicotinide. Then through the Hoffman rearrangement reaction, under alkaline conditions, bromine or chlorine is used as the reagent to promote the rearrangement of 6-chloronicotinide, and finally converted to 2-amino-6-chloropyridine. Although this path is slightly complicated, the raw materials are relatively easy to obtain, and the reaction conditions of each step are relatively easy to control.
There is also a method of using 2-aminopyridine as the starting material. For the chlorination reaction of 2-aminopyridine, select suitable chlorination reagents, such as N-chlorosuccinimide (NCS), etc. Under suitable solvents and reaction conditions, chlorine atoms are selectively introduced into the 6 position of the pyridine ring to synthesize 2-amino-6-chloropyridine. However, this process requires precise control of the reaction conditions to ensure the selectivity and yield of the chlorination reaction. Different synthetic methods have their own advantages and disadvantages, and it is necessary to choose carefully according to the actual situation, such as raw material cost, reaction conditions, product purity requirements, etc.

The price range of 2-amino-6-chloropyridine is difficult to determine in the market. The price of this compound often varies due to many factors. The method of its production, the price of the raw materials used, and the supply and demand of the market can all affect its price.
In the past, if its production is simple, the raw materials are cheap and sufficient, and the market demand is also stable, the price may be lower. However, if the production is complicated, the raw materials are rare, or the market demand increases suddenly, the price will rise.
In the chemical industry, under normal circumstances, the price of 2-amino-6-chloropyridine is between tens of yuan and hundreds of yuan per kilogram. If it is a high-purity product, it is suitable for fine chemical and pharmaceutical developers, and the price is higher, or thousands of yuan per kilogram.
However, the chemical industry market is fickle, and the fluctuation of raw material prices, changes in policies and regulations, and new innovations in technology can cause fluctuations in the price of 2-amino-6-chloropyridine. In order to know its exact price, it is necessary to check the market situation in real time and consult suppliers to obtain a near-real price.

2-Amino-6-chloropyridine is one of the chemical substances. Its storage conditions are crucial, which is related to the stability and quality of this substance.
When stored, the first environment is dry. Moisture can easily cause chemical reactions and damage its purity. Therefore, it should be placed in a dry place, away from a humid place, such as a basement or near a water source.
Temperature is also critical. It should be stored in a cool place. Generally speaking, the temperature should not exceed 30 ° C. Excessive temperature may intensify the movement of molecules, triggering reactions such as decomposition or polymerization.
Furthermore, it should be placed in a place protected from light. Light radiation or promote its photochemical reaction, causing it to deteriorate. Can be hidden in a brown bottle, or placed in a place without direct light.
At the same time, the storage place should be away from fire sources, heat sources and oxidants. This substance may be flammable, and it can be dangerous in case of open flames and hot topics; it is easy to react violently in contact with oxidants.
and the storage place should be well ventilated. Poor ventilation can cause the accumulation of harmful gases, which not only threatens the safety of the storage environment, but also affects the properties of the substance itself.
Another note should be that the storage container must be sealed. If the seal is not good, air, water vapor, etc. are easy to invade and cause deterioration. Commonly used glass or plastic containers should be made of materials that do not react with 2-amino-6-chloropyridine.
In short, in order to properly store 2-amino-6-chloropyridine, it is necessary to take into account dry, cool, dark, fireproof, ventilated and sealed conditions to ensure that the properties of this material are stable and the quality is not damaged.