2-amino-5-nitropyridine

2-Amino-5-nitropyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of drugs in the field of medicinal chemistry. The special structure of the Gainpyridine ring, together with the chemical activity of the amino group and the nitro group, makes it possible to participate in a variety of chemical reactions to construct compounds with specific biological activities. For example, in the development and synthesis of antibacterial and anti-inflammatory drugs, its unique chemical properties are often used to shape the effective structure of drug molecules to achieve specific pharmacological effects.
In the field of materials science, it also has its uses. It can be chemically modified to have specific optoelectronic properties, and then applied to the creation of organic optoelectronic materials. For example, in the development of organic Light Emitting Diode (OLED) materials, 2-amino-5-nitropyridine can be designed and modified by rational molecules, which may optimize the luminous efficiency and stability of the material, contributing to the development of OLED technology.
In addition, in the field of dye chemistry, because it contains chromophore groups, it may be used to synthesize new dyes. By adjusting and modifying its structure, it can modulate the color, stability and dyeing properties of dyes to meet the special needs of different industries for dyes.
In summary, 2-amino-5-nitropyridine has important uses in many fields such as medicine, materials, and dyes, and is an indispensable key substance for the development of chemical synthesis and related industries.

2-Amino-5-nitropyridine is a kind of organic compound. Its physical properties are quite important and can be described from the following numbers.
Looking at its properties, 2-amino-5-nitropyridine is often in a solid state at room temperature. As for the color, it is mostly light yellow to light brown. This color is more characteristic and can be an important basis for identifying this compound.
When it comes to the melting point, the melting point is about 170-175 ° C. The melting point is the temperature at which a substance changes from solid to liquid state. This specific melting point value is really crucial for the identification and purification of this compound. As for the boiling point, due to the limitations of the data, although it is difficult to say precisely, it can be known that its boiling point is higher than that of similar compounds in terms of its structure. It is more complex due to the intermolecular forces. It has both the polar effect caused by amino groups and nitro groups, and the conjugation effect of pyridine rings.
In terms of solubility, 2-amino-5-nitropyridine has little solubility in water. In water, polar solvents are also used. Although the compound contains polar groups amino and nitro, the existence of pyridine rings makes its overall polarity not very high, so it is insoluble in water. However, in organic solvents such as ethanol and dichloromethane, it has a certain solubility. Ethanol is an organic solvent with moderate polarity. It can form hydrogen bonds and other interactions with 2-amino-5-nitropyridine molecules, which is conducive to its dissolution. Although dichloromethane has a slightly weaker polarity, it can also partially dissolve the compound by virtue of its van der Waals force on the pyridine ring.
In addition, the density of 2-amino-5-nitropyridine is also one of its physical properties. Although the exact density value is difficult to know, it can be inferred that its density should be slightly higher than that of water. Due to the existence of pyridine ring, amino group and nitro group, the molecular weight is increased and the structure is relatively compact, resulting in a higher unit volume mass.
All these physical properties are of indispensable value in the study of the synthesis, separation, purification and application of 2-amino-5-nitropyridine, providing a solid foundation for chemists to understand and use this substance rationally.

2-Amino-5-nitropyridine is an organic compound with unique chemical properties. It contains an amino group (-NH _ 2) and a nitro group (-NO _ 2), which significantly affect the properties of this compound.
Amino groups are basic and can react with acids to form salts. In an acidic environment, amino groups are easily protonated to form positively charged ions, which enhances the water solubility of the compound. For example, when exposed to hydrochloric acid, amino-nitrogen atoms will combine hydrogen ions and become ammonium ions (-NH _ 3), making 2-amino-5-nitropyridine soluble in hydrochloric acid solutions.
Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the pyridine ring, causing its electrophilic substitution activity to decrease and its nucleophilic substitution activity to increase. For example, when electrophilic reagents attack the pyridine ring, the reaction is difficult to occur due to the electron-absorbing action of the nitro group; while nucleophilic reagents are more likely to react with the pyridine ring.
From the perspective of stability, the conjugation of nitro and amino groups affects the stability of compounds to a certain extent. At the same time, the steric resistance between the two can also affect the intermolecular forces and the physical properties of compounds.
In chemical reactions, 2-amino-5-nitropyridine can be used as an intermediate to participate in various organic synthesis reactions. Amino groups can be acylated, alkylated and other reactions; nitro groups can be reduced to amino groups, or participate in the construction of new carbon-nitrogen bonds and other reactions, which have potential application value in pharmaceutical chemistry, materials science and other fields.

To prepare 2-amino-5-nitropyridine, there are many methods, and the common ones are as follows.
First, 2-chloro-5-nitropyridine is used as the starting material and reacts with ammonia under suitable conditions. This reaction requires a suitable solvent, such as dimethylformamide (DMF) or dimethyl sulfoxide (DMSO), because it can dissolve the raw material and has no adverse effects on the reaction. Temperature is also critical, generally controlled within a certain range, such as 80-120 ° C. At the same time, adding an appropriate amount of acid binding agent, such as potassium carbonate or sodium carbonate, can help remove hydrogen chloride and make the reaction proceed forward to obtain 2-amino-5-nitropyridine.
Second, use 5-nitro-2-hydroxypyridine as a substrate to co-heat with ammonia and suitable catalysts. Common catalysts such as copper salts, such as cuprous chloride or copper sulfate. The reaction is carried out under appropriate pressure in a specific solvent, such as ethanol or ethylene glycol ether solvents. Such solvents facilitate the contact of substrates with ammonia and can stabilize the catalyst activity, promoting the substitution of hydroxyl groups with amino groups to form the target product.
Third, it can be gradually nitrified and aminated by pyridine derivatives. Nitro groups are introduced to specific positions of pyridine first, and then amino groups are introduced. The nitrification step requires mixed acids of nitric acid and sulfuric acid, and the nitro substitution positions are precisely controlled according to the reaction conditions and substrate activity. During amination, aminolysis reaction or other amination reagents can be used to realize the access of amino groups at designated positions, and 2-amino-5-nitropyridine can be obtained through multi-step reaction.
Each method has its own advantages and disadvantages. In actual operation, the optimal path should be selected to prepare 2-amino-5-nitropyridine according to the availability of raw materials, cost, product purity and other factors.

The price of 2-amino-5-nitropyridine in the market varies with time, place and quality, and it is difficult to know for sure. However, looking at past transactions, the approximate price range can be obtained.
In the market of chemical raw materials, if the quality is ordinary and the quantity is not much, the price per gram may be between a few yuan and tens of yuan. If the buyer has a large demand and has a long-term contract with the supplier, the price per gram may be reduced to a few yuan.
Furthermore, the price is also affected by the source of raw materials, the difficulty of preparation, and the supply and demand of the market. If the raw materials are easy to harvest, the preparation method is advanced, and the supply exceeds the demand, the price may decline; conversely, if the raw materials are rare, the preparation is difficult, and the demand exceeds the supply, the price may rise.
If you want an accurate price, you can consult the suppliers of chemical products, or check the trading platform of chemical raw materials, and the price there, or in near real time, can be used for reference. In addition, the chemical market is turbulent, and the price changes frequently. Therefore, buyers should consider the situation and choose the opportunity to buy in order to get the right price.