2-amino-5-methylpyridine-3-carboxylic acid

2-Amino-5-methylpyridine-3-carboxylic acid is one of the organic compounds. It has many unique chemical properties.
This compound contains amino (-NH2O), methyl (-CH
) and carboxyl (-COOH) on the pyridine ring. The amino group is basic, because the nitrogen atom has lone pair electrons, it can accept protons and can form salts in acidic media. And the amino group has high activity and is easy to participate in nucleophilic substitution reactions, such as interacting with acyl halides, acid anhydrides, etc., to form amides. < Br >
methyl group as the power supply group will affect the electron cloud density distribution of the pyridine ring, which increases the electron cloud density on the ring, especially in the adjacent and para-positions, and then has an effect on the localization of electrophilic substitution reactions.
Carboxyl groups are acidic because they can ionize protons. Under basic conditions, carboxyl groups easily react with bases to form carboxylic salts. At the same time, carboxyl groups can undergo many reactions, such as esterification with alcohols under the action of catalysts to form ester compounds.
Pyridine itself has special properties, with certain aromatic and weakly basic properties. Because the electronegativity of nitrogen atom is stronger than that of carbon atom, the electron cloud distribution of pyridine ring is uneven, the electron cloud density of nitrogen atom is relatively low in the adjacent and para-sites, and the electron cloud density of meta-site is slightly higher. This characteristic makes the electrophilic substitution reaction of pyridine ring often occur in the meta-site.
2-amino-5-methylpyridine-3-carboxylic acid shows a variety of chemical activities due to the interaction between these groups and the pyridine ring. It can be used as a key intermediate in the field of organic synthesis and participates in the preparation of many complex organic compounds.

2-Amino-5-methylpyridine-3-carboxylic acid, this is an organic compound with important uses in many fields.
In the field of medicinal chemistry, it can be a key intermediate. The design and synthesis of many drug molecules rely on it as the basic structure. Due to its specific chemical properties of pyridine rings with amino and carboxyl groups, it can participate in various chemical reactions to construct complex molecular structures with specific biological activities. For example, by condensation and substitution with other active groups, drugs with high affinity and selectivity for specific disease targets can be created, or used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs. < Br >
In the field of materials science, it can participate in the synthesis of polymer materials. Its functional groups can be polymerized with other monomers, giving the material special properties. Such as polymerization with monomers containing double bonds, or can prepare polymer materials with good optical properties, thermal stability or mechanical properties, or applied to optical lenses, electronic packaging materials, etc.
In agricultural chemistry, it also has potential uses. It can be chemically modified to create pesticides with insecticidal, bactericidal or herbicidal activities. The combination of pyridine rings with amino groups and carboxyl groups may enhance their biological activity against specific pests, pathogens or weeds, while reducing the impact on the environment and non-target organisms, providing the possibility for the development of green pesticides.
In addition, in organic synthetic chemistry, as an important intermediate, it can be used to synthesize other complex organic compounds, expand the way and method of organic synthesis, and promote the development of organic chemistry. Due to its unique chemical structure and reactivity, it provides chemists with rich strategies and possibilities for constructing novel molecular structures.

To prepare 2-amino-5-methylpyridine-3-carboxylic acid, a conventional number method is used. First, 5-methyl-2-nitro-3-pyridinecarboxylic acid is used as the starting point and obtained by reduction. This reduction method can be obtained by catalytic hydrogenation, with the help of appropriate catalysts such as palladium carbon, through hydrogen to convert nitro groups to amino groups. The conditions of this method are peaceful and the product is relatively pure. However, attention should be paid to the activity of the catalyst and the safety of the hydrogen source.
Second, with 2-halo-5-methylpyridine-3-carboxylic acid as substrate, react with ammonia source. The ammonia source can be selected from ammonia water, liquid ammonia, etc. Under suitable temperature and pressure, the halogen atom is substituted by amino group. The reaction conditions need to be controlled to prevent side reactions from occurring, such as the emergence of multiple substituted products.
Third, it is constructed from suitable pyridine derivatives through multi-step reaction. First, nitro is introduced with 5-methylpyridine as the base, and then carboxylated at an appropriate check point, and finally the nitro is reduced to amino group. Although this path is complicated, the selectivity of each step can be used to obtain the target product accurately. Each method has its own advantages and disadvantages. When it is implemented, the best method should be selected according to the availability of raw materials, the conditions of equipment, and the consideration of cost.

There are 2-amino-5-methylpyridine-3-carboxylic acids in the market today. What is their price? According to the model of "Tiangong Kaiwu", it is difficult to find its exact price when looking at the past. This is a new thing, and it is not covered in ancient books. However, in today's world, the amount of price depends on many reasons.
The difficulty of its production is related to the price. If the production is complex, it requires concentrate and wonderful methods, and it is labor-intensive and time-consuming, the price will be high. The abundance of raw materials is also heavy. If raw materials are rare and difficult to obtain, their price will be high. Furthermore, the supply and demand of the market determines its price. If there are many seekers, and there are few suppliers, the price will rise; otherwise, the price will be reduced. < Br >
Although there is no definite price, according to the current situation of chemical products. If it is an ordinary reagent grade, the purity is moderate, and the price per gram may be between tens and hundreds of yuan. If it is of high purity, it is used in fine synthesis, pharmaceutical research and development, and the price per gram may exceed 100 yuan, or even hundreds of yuan. This is all speculation, and the actual price needs to be consulted with chemical reagent manufacturers and material trading markets to determine the exact number.

2-Amino-5-methylpyridine-3-carboxylic acid, this is a chemical substance. Its storage conditions are quite critical, related to its quality and stability.
According to the concept of "Tiangong Kaiwu", where things are hidden, their properties need to be determined. This acid has specific chemical properties and should be placed in a cool, dry and well-ventilated place. If it is cool, it should be prevented from changing due to heat. If the temperature is too high, it may cause its chemical structure to change, lose its activity, and even cause chemical reactions to deteriorate. A dry environment is indispensable because it may easily absorb moisture, invade it with water and moisture, or cause acidification and deliquescence, which will damage its purity and quality. If it is well ventilated, it can disperse the harmful gases that may be volatilized, and keep the environment fresh, so as not to cause danger due to gas accumulation.
Furthermore, it is necessary to keep away from fire and heat sources. This acid may be flammable or easy to react violently in contact with heat and fire, endangering safety. And it should be separated from oxidants and alkalis, etc., and the cover should be closed because of its chemical activity. If it encounters them, it may cause unpredictable chemical reactions, causing explosions, fires and other disasters.
Packaging also needs to be cautious. It is advisable to use a sealed container to block the disturbance of external factors such as air and moisture to ensure the stability of its chemical properties. In this way, following suitable storage conditions, the characteristics and quality of 2-amino-5-methylpyridine-3-carboxylic acid can be maintained for a long time to prepare for subsequent applications.