2-Amino-5-methyl-3-nitropyridine

2-Amino-5-methyl-3-nitropyridine has quite specific chemical properties. This compound contains amino, methyl and nitro groups on the pyridine ring.
Amino is basic and can form salts with acids. Under appropriate conditions, it can participate in nucleophilic substitution reactions because nitrogen atoms have lone pairs of electrons and can attack electron-deficient groups. In case of acyl halide or acid anhydride, amino groups can undergo acylation reactions to form amide derivatives. This reaction is often used in organic synthesis to construct amide bonds. The electron cloud density distribution of the pyridine ring can be affected by the activity of methyl group, which is slightly inferior to that of amino group and nitro group, and the electron cloud density of the adjacent and para-position increases slightly. In the electrophilic substitution reaction, the selectivity of the reaction check point is affected.
Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the pyridine ring and makes it difficult for the electrophilic substitution reaction on the ring to occur. However, nitro can be reduced to amino group under specific reduction conditions. For example, in the reduction system of iron powder and hydrochloric acid, nitro can be converted into amino group, which can increase the number of amino groups in the molecule and change its chemical properties and reactivity.
In addition, the pyridine ring of 2-amino-5-methyl-3-nitropyridine itself is aromatic and has certain stability. It can participate in many reactions related to aromatic rings, such as substitution with electrophilic reagents, or coupling reactions with metal-organic reagents. It has great application potential in the field of organic synthesis chemistry.

The common synthesis methods of 2-amino-5-methyl-3-nitropyridine are of interest in the field of organic synthesis. There are various methods, which can be started from different starting materials and reaction paths.
First, use 5-methylpyridine-2-amine as the starting material. First, use a suitable nitrifying agent, such as a mixture of concentrated nitric acid and concentrated sulfuric acid, and carry out the nitrification reaction under suitable conditions. This reaction needs to be controlled by temperature to prevent side reactions. Usually at low temperature, such as 0-5 ° C, the nitrifying agent is slowly added dropwise to selectively introduce the nitro group to the 3rd position. Due to the electron cloud distribution on the pyridine ring and the positioning effect of methyl and amino groups, nitro can be guided into the desired position. After this reaction, the target product 2-amino-5-methyl-3-nitropyridine can be obtained.
Second, 2-chloro-5-methylpyridine can also be started. First, the chlorine atom is replaced by an amino group to form 5-methylpyridine-2-amine. Then, according to the above nitration steps, the obtained 5-methylpyridine-2-amine is nitrated to obtain 2-amino-5-methyl-3-nitropyridine. Although this path has a little more steps, the selectivity and yield of each step can be adjusted.
Or, 5-methyl-2-hydroxypyridine is used as the raw material. First, the hydroxyl group is converted into a suitable leaving group, such as by reacting with chlorination reagents to generate 2-chloro-5-methylpyridine, and then ammonolysis, nitrification and other steps can also achieve the synthesis of the target product.
All synthesis methods have their own advantages and disadvantages. According to actual needs, factors such as the availability of raw materials, the difficulty of controlling reaction conditions, cost and yield should be considered in order to choose the most suitable synthesis path.

2-Amino-5-methyl-3-nitropyridine is useful in various fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Because of the specific amino, methyl and nitro groups on the pyridine ring, it can be modified by various chemical reactions to produce compounds with special pharmacological activities. For example, it can be used to create antibacterial drugs, whose structure can be combined with specific bacterial targets to interfere with bacterial metabolic processes and achieve antibacterial effects; or it can be used to develop anti-tumor drugs, through which its structure interacts with key proteins of cancer cells to block the proliferation pathway of cancer cells.
In the field of materials science, 2-amino-5-methyl-3-nitropyridine also has potential uses. It can participate in the preparation of organic materials with special functions, such as photovoltaic materials. Its unique electronic structure may enable the materials to exhibit excellent photoelectric properties, such as fluorescence properties, which can be used to manufacture organic Light Emitting Diodes (OLEDs) to improve the efficiency of display technology; or it can enhance the charge transport ability of materials, play a role in the preparation of solar cell materials, and improve solar energy conversion efficiency.
In the field of pesticide chemistry, this compound may be the cornerstone of the creation of new pesticides. With the affinity of its structure to biomolecules in pests, high-efficiency and low-toxicity insecticides or fungicides may be developed. For example, after appropriate modification, it can precisely act on the nervous system or respiratory system of pests, inhibit the normal physiological function of pests, and have little impact on the environment and non-target organisms, contributing to the sustainable development of agriculture.

I think this 2 - Amino - 5 - methyl - 3 - nitropyridine is a kind of organic compound. Its market price is difficult to say in a word. The price of this compound often changes due to various factors.
The first to bear the brunt is the cost of production. The price of raw materials may fluctuate due to changes in weather, geographical location, and supply and demand. If raw materials are scarce, their price will be high, and the cost of this compound will also rise, and the market price will rise as the tide rises. And the production process, if it requires exquisite and complicated methods, those who consume manpower, material resources, and financial resources will also be expensive.
Furthermore, the relationship between supply and demand in the market has a deep impact on its price. If the demand for this product increases sharply in a certain area at a certain time, but the supply is limited, just like the reason why it is rare and expensive, its price will rise. On the contrary, if there is an excess supply and little demand, the price may fall.
In addition, the quality is also related to the price. Those with high purity and high quality will get a higher price for themselves; those with lower quality will also get a slightly lower price.
And the state of market competition should not be underestimated. If there are many peers in the industry competing for profits, there may be those who compete for the market at a price, resulting in lower prices. However, if there is no competition, the price may be higher if there is only one company or a few supply.
As for the exact market price, it is difficult to say. It is necessary to pay attention to the dynamics of the chemical market in time and consult the supplier to get a more accurate price. Or check in detail on the chemical trading platform to know the price at that time.

2-Amino-5-methyl-3-nitropyridine is a kind of organic compound. Its physical properties are particularly important, and it is related to its performance in various chemical processes.
First of all, its appearance is usually in a solid state. This solid state is easy to store and transport, and it can be used as a stable reactant in many reaction systems. Looking at its color, it is mostly light yellow to light brown. This color characteristic can help chemists to have a basis for preliminary identification.
As for the melting point, it is within a certain range. The melting point is an inherent physical property of the substance and is extremely critical in the purification and identification of this compound. By accurately measuring the melting point, its purity can be judged. If the melting point is consistent with the literature, the purity is high; if there is a deviation, it may contain impurities.
Solubility is also an important physical property. In common organic solvents, such as ethanol, dichloromethane, etc., it has a certain solubility. This solubility allows chemists to choose a suitable solvent according to different reaction requirements to build a reaction system and promote the reaction. In water, its solubility is relatively limited, and this property also affects its application in some aqueous reactions.
Furthermore, its density also has a specific value. The size of the density is quite useful when it involves solution preparation, separation and purification. Knowing its density, you can accurately measure the required amount to ensure the accuracy of the experiment.
The physical properties of 2-amino-5-methyl-3-nitropyridine, such as appearance, melting point, solubility, density, etc., are all indispensable factors for chemists to consider when studying and applying this compound, and are of great significance in many fields such as organic synthesis and drug development.