2-Amino-5-methoxypyridine

2-Amino-5-methoxypyridine is widely used in the field of organic synthesis. Its primary use lies in the end of pharmaceutical creation. This compound has a unique chemical structure and can add specific activities and properties to drug molecules. In the process of drug development, it is often used as a key intermediate. Through complex chemical reactions, novel drugs with therapeutic effects are constructed.
As in the development of antibacterial drugs, 2-amino-5-methoxypyridine can be used as a starting material. After multiple steps of reaction, a substance with strong inhibitory effect on specific bacteria is generated. In the exploration of anti-tumor drugs, based on this, molecules that can precisely bind to tumor cell targets can be constructed to block the growth and spread of tumors.
In addition to the field of medicine, in the creation of pesticides, 2-amino-5-methoxypyridine can also be used. It can be used to synthesize pesticide ingredients with high insecticidal and bactericidal properties. Such pesticides may be more selective than traditional ones, have strong killing power against target pests, and are environmentally friendly, reducing the impact on non-target organisms.
Furthermore, in the field of materials science, 2-amino-5-methoxypyridine can participate in the synthesis of special functional materials. For example, the preparation of organic materials with unique optical and electrical properties can be used in the field of optoelectronics, such as the manufacture of organic Light Emitting Diodes (OLEDs), solar cells, and other devices, providing new avenues for material performance optimization and innovation.

2-Amino-5-methoxypyridine is also an organic compound. It has unique physical properties, which are described in detail today.
First of all, under normal temperature and pressure, 2-amino-5-methoxypyridine is often white to light yellow crystalline powder. This appearance is easy to identify. In experiments and production, its shape and color can be initially judged.
The melting point is about 94-98 ° C. The melting point is an important physical constant of the substance. When heated to this temperature range, the compound gradually melts from a solid state to a liquid state. This property is of great significance in the identification and purification process. Knowing its melting point, you can use the method of melting point determination to test its purity. If the measured melting point matches or is similar to the standard value, its purity is higher; if the deviation is large, it contains more impurities.
In addition, its solubility is also a key property. 2-Amino-5-methoxy pyridine is soluble in common organic solvents, such as methanol, ethanol, dichloromethane, etc. In methanol and ethanol, due to the principle of similar miscibility, the compound molecules interact with alcohol molecules and disperse uniformly to form a solution. In water, its solubility is relatively limited. This solubility characteristic can provide a basis for the selection of suitable reaction solvents in organic synthesis reactions. If the reaction needs to be carried out in a homogeneous system, a suitable solvent can be selected according to its solubility to promote the smooth occurrence of the reaction.
In addition, the compound has certain stability. Under conventional storage conditions, in a dry and cool place, its chemical structure and properties can be maintained unchanged. In case of extreme conditions such as strong acid, strong base or high temperature, its structure may be damaged, causing chemical reactions and causing changes in properties. Therefore, such unfavorable factors need to be avoided when storing and using.
The physical properties of 2-amino-5-methoxy pyridine play a pivotal role in the field of organic chemistry, whether it is synthetic application or analytical identification, providing important reference for related research and production practice.

The synthesis methods of 2-amino-5-methoxypyridine are described in ancient books, and there are many methods. The common ones mentioned today are for you.
First, starting with 5-methoxypyridine-2-carboxylic acid, amidation, and then treatment with a strong reducing agent such as lithium aluminum hydride, the carboxyl group can be converted into an amino group to obtain 2-amino-5-methoxypyridine. During this process, the amidation step needs to select suitable conditions to make the reaction smooth and efficient. The reagents used need to be pure, and the reaction temperature and time need to be precisely controlled to obtain a higher yield.
Second, starting from 2-chloro-5-methoxypyridine, this halogenated pyridine reacts with ammonia sources, such as liquid ammonia, ammonia water or organic amines, under suitable conditions. Or add a catalyst to promote the nucleophilic substitution reaction. This reaction requires attention to the activity of halogenated pyridine, as well as the amount of ammonia source and the reaction environment. Temperature, pressure and other factors will affect the reaction process. If the conditions are not appropriate, side reactions will easily occur and the product will be impure.
Third, methoxypyridine derivatives are used as raw materials, through nitrification, reduction and other steps. Nitro is introduced first, and then nitro is reduced to amino. When nitrifying, the mixed acid ratio of nitric acid and sulfuric acid, the reaction temperature, etc. are all key. The reduction step can be selected from a suitable reducing agent, such as iron filings and hydrochloric acid system, or catalytic hydrogenation. However, catalytic hydrogenation requires specific catalysts and reaction devices, and the reaction conditions are strict.
All synthesis methods have advantages and disadvantages. It is necessary to choose carefully according to the actual situation, such as the availability of raw materials, cost, product purity requirements, etc., in order to achieve the ideal synthesis effect.

2-Amino-5-methoxypyridine is an organic compound. During storage and transportation, it is necessary to pay attention to many key matters to ensure safety and quality.
First, when storing, the first environment is dry. This compound is easily affected by moisture, causing it to deteriorate or undergo chemical reactions. Therefore, it should be placed in a dry place, away from water sources and places with high humidity. If it is in a warehouse, it is advisable to lay moisture-proof mats, and the humidity of the warehouse should be controlled within an appropriate range, usually 40% - 60% relative humidity.
Second, temperature is also critical. It should be stored in a cool environment, protected from high temperature and direct sunlight. High temperature can affect the stability of the compound, or cause reactions such as decomposition. Generally speaking, the storage temperature should be maintained between -15 ° C and 25 ° C. If the temperature is too high, it can cause its volatilization to accelerate and even cause safety hazards.
Third, the packaging must be tight. Appropriate packaging materials should be selected to ensure good sealing. Commonly used glass bottles or plastic bottles, plus cartons or wooden boxes reinforced. Prevent air, moisture, etc. from coming into contact with it, and avoid oxidation or other adverse chemical reactions.
Fourth, when transporting, ensure that the packaging is stable. Avoid violent vibrations and collisions on the way to prevent package damage. Transportation vehicles need to have good shock absorbers, and the route should avoid high temperature areas and densely populated areas.
Furthermore, this compound has certain toxicity and irritation. Storage and transportation personnel must take protective measures, wearing protective clothing, gloves and protective glasses, etc. After the operation, wash the contact parts in time to prevent harm to the body.
In short, 2-amino-5-methoxypyridine has strict requirements on the environment, packaging and personnel protection during storage and transportation, so as to ensure its quality and safety.

The commercial price range of 2-amino-5-methoxypyridine often varies due to a variety of factors. Among these factors, the first one is purity. High purity 2-amino-5-methoxypyridine, because of its difficult preparation, complicated process, requires more raw materials, man-hours and technology, so the price is high. If the purity is above 99%, the price per gram may be in the hundreds of yuan. And if the purity is slightly lower, such as about 95%, the price may be greatly reduced, or only a few tens of yuan per gram.
Secondly, market supply and demand also affect its price. If there is a surge in demand for 2-amino-5-methoxypyridine in a certain field at a certain time, such as the key intermediate in the field of pharmaceutical synthesis, and the supply is relatively insufficient, the price will rise. On the contrary, if the market demand is weak and the supply is abundant, the price will go down.
Furthermore, the amount of purchase is also related to the price. Buying in bulk can often enjoy discounts because it can reduce the cost of packaging and transportation for the seller. If you buy several kilograms or more at one time, the price per gram may be lower than when you buy a small amount.
In addition, different suppliers have different pricing strategies. Well-known large factories, with their technological and quality advantages, may have higher prices; while some emerging or small factories, in order to seize the market, the price may be more close to the people.
Overall, the laboratory buys a small amount, 98% purity products, the price per gram may be 100-300 yuan. Industrial large-scale purchases, 95% purity, the price per kilogram may be in the thousands. However, this is only a rough range, the actual price depends on the specific market conditions, the time of transaction and other factors.