2-Amino-5-iodo-3-methyl-pyridine

2-Amino-5-iodine-3-methylpyridine is a class of organic compounds. Its main uses are widely involved in the fields of pharmaceutical chemistry and materials chemistry.
In pharmaceutical chemistry, this compound is often a key intermediate for the synthesis of drugs. Due to its unique structure, it can participate in a variety of chemical reactions to build complex drug molecular structures. For example, by using a specific reaction path, it can be introduced into a molecular system with biological activity, or used to modify existing drug molecules, thereby improving the pharmacological properties of drugs, such as enhancing the bioavailability of drugs, enhancing the affinity of drugs to targets, and optimizing the metabolic stability of drugs. In the development of some antibacterial and antiviral drugs, 2-amino-5-iodine-3-methylpyridine plays an important role in the synthesis of new drugs with better efficacy and fewer side effects.
In the field of material chemistry, 2-amino-5-iodine-3-methylpyridine also shows unique value. Because of its nitrogen, iodine and other atoms, it can endow materials with specific electronic properties and spatial structures. In the synthesis of organic optoelectronic materials, the introduction of this substance can regulate the optical and electrical properties of the materials. For example, in the preparation of organic Light Emitting Diode (OLED) materials, the appropriate application of 2-amino-5-iodine-3-methylpyridine can optimize the luminous efficiency and color purity of the material, and provide help to improve the display performance of OLED devices. And in the synthesis of some functional polymer materials, it can participate in the polymerization reaction as a structural unit, endowing the polymer materials with unique chemical and physical properties, such as thermal stability, solubility, etc., to expand the application of polymer materials in different fields.

2-Amino-5-iodine-3-methylpyridine, this is also an organic compound. Its physical properties are quite important and are related to many chemical applications.
Looking at its properties, under normal temperature and pressure, it is often in a solid state. However, the specific color state may vary depending on the purity and preparation method, and it is mostly white to light yellow crystalline powder. This color state is convenient for preliminary identification and distinction.
When it comes to the melting point, it is about a specific temperature range. This value is of great significance for the identification and purification of the compound. Accurate determination of the melting point can help determine its purity. If the melting point deviation is large, or it suggests that there are impurities mixed in. < Br >
In terms of solubility, it varies in common organic solvents. In polar organic solvents such as methanol and ethanol, there is a certain solubility. Due to the principle of similar miscibility, its molecular structure contains polar groups, which interact with polar solvents and are conducive to dissolution. However, in non-polar solvents such as n-hexane, the solubility is very poor.
Furthermore, its density is also an important physical property. Although the exact value needs to be determined by professional means, its density affects its distribution and behavior in the reaction system. When it comes to liquid-liquid reactions or separation processes, the density factor cannot be ignored.
In terms of volatility, this compound has low volatility and is not easy to evaporate into the air at room temperature, which is more advantageous in terms of storage and operation safety, and can reduce losses and potential hazards caused by volatilization.
The physical properties of 2-amino-5-iodine-3-methylpyridine are key considerations in chemical research, synthesis and application, and help chemists control their behavior and reaction characteristics.

2-Amino-5-iodine-3-methylpyridine, this is an organic compound with unique chemical properties. In its structure, the pyridine ring is the basis, and the amino group, iodine atom and methyl group each occupy a specific position. These groups give the compound unique characteristics.
Let's talk about the amino group first. The amino group is basic. Because there are lone pairs of electrons on the nitrogen atom, it can bind protons. In an acidic environment, the amino group is easily protonated, making the compound positively charged. This property affects its solubility and chemical reactivity. For example, in an acidic aqueous solution, it can react with acids to form corresponding salts.
Look at the iodine atom again. The iodine atom has a large relative atomic mass and high electronegativity. This makes the C-I bond energy relatively small and prone to fracture, so the location of the iodine atom in the compound is chemically active. In nucleophilic substitution reactions, iodine atoms are easily replaced by other nucleophiles, which become a check point for introducing new functional groups.
As for methyl groups, it is a power supply group, which will produce electronic effects on the pyridine ring, increasing the electron cloud density of the pyridine ring, which in turn affects the reactivity of other positions on the ring. Usually, the electron supply action of methyl groups will increase the density of the adjacent and para-position electron clouds more, and when the electrophilic substitution reaction occurs, the electrophilic reagents are more likely to attack these positions. Due to the interaction of these groups, 2-amino-5-iodine-3-methylpyridine exhibits unique chemical properties and is often used as a key intermediate in the field of organic synthesis for the construction of more complex organic molecular structures.

To prepare 2-amino-5-iodine-3-methylpyridine, there are three methods. First, 3-methylpyridine is used as the beginning, and can be obtained by nitration, reduction, diazotization and iodine substitution. First, 3-methylpyridine is heated with mixed acid and nitrified to obtain 5-nitro-3-methylpyridine. After iron powder or lithium aluminum hydride is used as the reducing agent, nitro is converted into amino group in a suitable solvent to obtain 5-amino-3-methylpyridine. The product is then blended with sodium nitrite and acid, diazotized at low temperature, and then interacted with potassium iodide to obtain the target by iodization.
Second, 2-amino-3-methylpyridine is used as the starting material and prepared by halogenation reaction. Take 2-amino-3-methylpyridine, dissolve it in a suitable solvent, add iodine and an oxidizing agent, such as hydrogen peroxide or periodic acid, and react under mild conditions. The iodine atom can be selectively added to the 5-position to obtain 2-amino-5-iodine-3-methylpyridine.
Third, pyridine derivatives are used as substrates and modified in multiple steps. First, pyridine with appropriate substituents is selected, and methyl and amino groups are introduced through functional group conversion. After halogenation, 5-position iodization is made with iodine substitutes, and the final product is obtained. Each of these methods has advantages and disadvantages, and the actual operation needs to be selected according to factors such as the availability of raw materials, cost and yield.

There is a question about the price range of 2-amino-5-iodine-3-methyl-pyridine in the market today. Looking at the method of "Tiangong Kaiwu", although it does not specify the price of this product, it can be based on common sense.
The price of various products in the market often depends on a variety of factors. The difficulty of obtaining its raw materials, the simplicity of production, the wide range of uses, and the amount of supply and demand are all important factors. 2-Amino-5-iodine-3-methyl-pyridine, if its raw materials are rare, difficult to find, and complicated to produce, through multiple processes, labor and material resources, its price will be high.
And if this material is widely used, it is indispensable in medicine, chemical industry and other industries. There are many demanders, and the supply is limited, its price will also be high. On the contrary, if the raw materials are easy to obtain, easy to make, narrow in use, and oversupply, the price will be low.
According to the general market conditions, the price of 2-amino-5-iodine-3-methyl-pyridine per gram may be between tens and hundreds of yuan without special reasons. However, this is only a guess, and the actual price should vary according to changes in the market and time. The market has endless changes, and it is necessary to keep an eye on it before you can know its exact price.