2 Amino 5 Hydroxypyridine
pyridine pyrrole pyrazine piperidine piperazine

2-Amino-5-hydroxypyridine

    Specifications

    HS Code

    669792

    Name 2 - Amino - 5 - hydroxypyridine
    Molecular Formula C5H6N2O
    Molar Mass 110.11 g/mol
    Appearance Solid (usually white or off - white)
    Odor May have a faint, characteristic odor
    Melting Point ~198 - 202 °C
    Solubility In Water Moderately soluble
    Pka For the amino group around 4 - 5, for the hydroxyl group around 9 - 10
    Density Approximately 1.3 - 1.4 g/cm³
    Stability Stable under normal conditions, but may react with strong oxidizing agents

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    General Information
    Where to Buy 2-Amino-5-hydroxypyridine in China?
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    Frequently Asked Questions

    As a leading 2-Amino-5-hydroxypyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Amino-5-hydroxypyridine?
    2-Amino-5-hydroxypyridine has a wide range of uses. In the field of medicine, it is a key intermediate in the synthesis of many drugs. Due to its unique chemical structure, it can be combined with other chemical groups through specific reactions to construct drug molecules with specific pharmacological activities. For example, when developing targeted drugs for specific diseases, 2-amino-5-hydroxypyridine can act as a basic framework to help drugs act precisely on diseased cells and achieve therapeutic effects.
    In the field of pesticides, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides. The pesticides produced have high-efficiency inhibition and killing ability against pests and are relatively friendly to the environment. Due to its structure, pesticides can give unique insecticidal mechanisms, which can interfere with the physiological activities of pests, such as destroying their nervous system or affecting their growth and development process.
    In the field of materials science, 2-amino-5-hydroxypyridine also has a place. It can participate in the preparation of functional materials, such as for the synthesis of some polymer materials with special optical or electrical properties. By copolymerizing with other monomers, it can change the molecular arrangement and electron cloud distribution of the material, and then adjust the photoelectric properties of the material to meet the needs of different application scenarios, such as in the field of optoelectronic device manufacturing.
    Furthermore, in organic synthetic chemistry, 2-amino-5-hydroxypyridine is used as an excellent reaction substrate and participates in many organic reactions. Due to the activity of amino and hydroxyl groups, it can trigger various reactions such as nucleophilic substitution and condensation, providing the possibility for the construction of complex organic molecular structures, and assisting organic synthesis chemists to create more novel and potentially valuable organic compounds.
    What are the physical properties of 2-Amino-5-hydroxypyridine?
    2-Amino-5-hydroxypyridine is also an organic compound. It has unique physical properties and is worth studying.
    First of all, its appearance, at room temperature, is mostly white to light yellow crystalline powder, fine and uniform in quality, and has a certain luster in appearance. This is one of the characteristics to distinguish it.
    As for the melting point, it is about 195-199 ° C. For the melting point, the critical temperature at which the substance changes from solid to liquid. This temperature range is relatively stable and is an important basis for identification and purity determination.
    In terms of solubility, 2-amino-5-hydroxypyridine is slightly soluble in water. Water is the source of all things, and many substances have different affinities with it. Its slightly soluble properties are due to the interaction of groups contained in the molecular structure with water molecules. However, in organic solvents, such as ethanol and methanol, it has better solubility. Organic solvents such as ethanol and methanol have specific chemical properties, and can form a suitable force with 2-amino-5-hydroxypyridine molecules to help them disperse and dissolve.
    Furthermore, 2-amino-5-hydroxypyridine has certain sublimation properties. Sublimation is the process of a substance from a solid state to a gaseous state without going through a liquid state. Although the sublimation phenomenon is not very significant, it can also be observed under specific conditions. This property is related to the intermolecular force and vapor pressure, reflecting its state changes under different temperatures and pressures.
    Because its molecular structure contains amino and hydroxyl groups, it has a certain polarity. The existence of polarity affects its interaction with other substances, and is of great significance in chemical reactions and material applications.
    In summary, the physical properties of 2-amino-5-hydroxypyridine, such as appearance, melting point, solubility, sublimation and polarity, are interrelated, forming its unique physical properties, which are indispensable in chemical research and related industrial applications.
    Is 2-Amino-5-hydroxypyridine chemically stable?
    2-Amino-5-hydroxypyridine is one of the organic compounds. In terms of the stability of its chemical properties, many factors need to be explored in detail.
    In terms of molecular structure, its pyridine ring has a certain stability. Because the pyridine ring is a conjugated system, the electron cloud distribution is relatively uniform, giving the molecule a certain stability. The introduction of amino and hydroxyl groups has an impact on the stability. The nitrogen atom of the amino group has lone pairs of electrons, which can participate in the conjugation system, which can increase the electron cloud density and enhance the stability to a certain extent. However, the oxygen atom of the hydroxyl group has a high electronegativity, which can attract electrons and change the electron cloud density distribution on the pyridine ring.
    In a chemical environment, the stability of 2-amino-5-hydroxypyridine is influenced by factors such as temperature and pH. When the temperature rises, the molecular thermal motion intensifies, and the chemical bond vibration enhances, resulting in a decrease in stability. In an acidic environment, amino groups are easily protonated, changing the molecular charge distribution and electron cloud structure, or changing the stability; in an alkaline environment, hydroxyl groups may participate in the reaction and affect the stability.
    In terms of chemical reaction activity, both amino and hydroxyl groups are active check points and can participate in many reactions, such as nucleophilic substitution, acylation, alkylation, etc. Such reactions may change the molecular structure and affect the stability.
    Overall, the stability of 2-amino-5-hydroxypyridine is not absolute, but varies according to the specific environment and conditions. Under suitable mild conditions, it may have certain stability; in case of extreme conditions or specific reaction reagents, its structure may change, and the stability will also change.
    What are 2-Amino-5-hydroxypyridine synthesis methods?
    The synthesis method of 2-amino-5-hydroxypyridine has been known for a long time. The methods are diverse, each has its own advantages and disadvantages, and has also evolved over time.
    First, it can be initiated by specific pyridine derivatives. After delicate reactions, such as substitution reactions with specific reagents under suitable conditions, the pyridine matrix is first placed in a carefully prepared reaction system, which contains suitable solvents, catalysts, etc. The catalyst is the key to the reaction, which can significantly change the rate of chemical reactions and make the reaction proceed in the desired direction. Under the right temperature and pressure, the reagent is fully contacted with the pyridine parent body, and after a series of complex chemical changes, the structure of the target molecule is gradually constructed, and the final product is 2-amino-5-hydroxypyridine.
    Second, it can also use small molecules containing nitrogen and oxygen as raw materials. Through multi-step reactions, atoms are cleverly spliced to form a pyridine ring. Initially, the small molecule raw materials undergo a condensation reaction in a specific reaction step to form the skeleton structure of the foundation. Subsequently, amino and hydroxyl groups are precisely introduced through modification steps. This process requires strict control of the reaction conditions. Slight deviations in temperature and pH may affect the purity and yield of the product. Each step of the reaction requires fine operation, just like carving beautiful jade, so that the atoms can be arranged as expected to achieve the target product.
    Furthermore, there is the use of biosynthesis. With the help of enzymes in the body, with their efficient and specific catalytic ability, the reaction is promoted. In a suitable biological system, providing a suitable substrate, the enzyme can play its unique role in guiding the substrate to react and generate 2-amino-5-hydroxypyridine. This biosynthesis method is relatively green and environmentally friendly, and the reaction conditions are mild. However, it requires a high degree of biological system. It requires careful maintenance of its environment to ensure the activity and stability of the enzyme in order to achieve a smooth synthesis.
    What is the price range of 2-Amino-5-hydroxypyridine in the market?
    The price of 2-amino-5-hydroxypyridine in the market varies for various reasons. This compound has a wide range of uses and is useful in many fields such as medicine, pesticides, materials, etc. The demand for it has a deep impact on the price.
    If the quantity is high, the supplier may reduce its price due to the scale effect; on the contrary, if the quantity is low, the price may increase. Furthermore, the difficulty of its production also affects the price. The synthesis of this compound requires specific reaction steps. The price of the raw material and the control of the reaction conditions are all related to the cost. If the raw material is scarce and the price is high, or the reaction conditions are harsh, the cost will increase, and the price will also rise.
    Looking at past market conditions, its price fluctuates within a certain range. However, due to rapidly changing market conditions, it is difficult to determine its exact price range. According to past transactions and market speculation, its price may vary due to quality and supply volume, and the price per gram may range from tens of yuan to hundreds of yuan. For real-time and accurate prices, it is advisable to consult chemical product suppliers, chemical raw material trading platforms, etc., where the exact quotation can be obtained at the moment to meet the needs of procurement or research.