2-Amino-5-fluoro-3-methylpyridine

2-Amino-5-fluoro-3-methylpyridine has a wide range of uses in the field of organic synthesis. Its primary use is in the preparation of medicine. The compound has a specific chemical structure and can be used as a key intermediate in the synthesis of medicine. When creating antibacterial, anti-cancer and other drugs, it is often relied on as the starting material, and through a series of delicate chemical reactions, complex drug molecular structures are constructed to achieve the effect of treating diseases.
Furthermore, in the field of pesticides, it also has important uses. Using it as a raw material, new pesticides can be developed. Due to the characteristics of this compound, the pesticide produced may have high insecticidal and bactericidal properties, and has a small impact on the environment, which is in line with the current concept of green environmental protection and contributes a lot to the sustainable development of modern agriculture.
In addition, in the field of materials science, 2-amino-5-fluoro-3-methylpyridine has also emerged. Functional polymer materials can be prepared by its participation in specific polymerization reactions. Such materials may have unique electrical and optical properties, and have potential application value in electronic devices, optical instruments and other fields, which can inject new vitality into the development of related industries.
In conclusion, 2-amino-5-fluoro-3-methylpyridine plays an important role in many fields such as medicine, pesticides, and materials science. It has a wide range of uses and is of great significance to promoting the progress of related industries.

2-Amino-5-fluoro-3-methylpyridine, this is an organic compound with specific physical properties. Its properties are often in the form of off-white to light yellow crystalline powders, with a fine texture. As far as the melting point is concerned, it is between 108 and 112 ° C. This temperature limit allows the substance to undergo a phase transition under a specific thermal environment.
Its solubility is also an important physical property. In organic solvents, such as common alcohols such as methanol and ethanol, as well as halogenated hydrocarbon solvents such as dichloromethane and chloroform, it exhibits good solubility and can be uniformly dispersed to form a homogeneous system. However, its solubility in water is relatively poor, due to the weak interaction between the functional groups contained in its molecular structure and the water molecules.
The compound has a density of about 1.28 g/cm ³, which reflects its mass characteristics per unit volume. When mixed with other substances or participating in physical processes, density factors can affect the physical behavior of the system. In addition, its low vapor pressure means that at room temperature and pressure, the tendency of volatilization to the gas phase is relatively small, which helps to maintain its stability in solid or liquid states.
The physical properties of 2-amino-5-fluoro-3-methylpyridine are of great significance in many fields such as organic synthesis and medicinal chemistry, and provide a key basis for its operation and use in various reactions and applications.

2-Amino-5-fluoro-3-methylpyridine, this is an organic compound. Looking at the stability of its chemical properties, it is necessary to investigate its molecular structure and chemical bond characteristics in detail. Its molecules contain amino groups, fluorine atoms and methyl groups, and the interaction of each group has a special impact on its stability under specific conditions.
Amino groups have a certain degree of alkalinity, and lone pairs of electrons on nitrogen atoms can participate in chemical reactions. When encountering acids, they are prone to form salts, which may cause structural changes and affect stability. Fluorine atoms are highly electronegative. When bonding with carbon atoms, their strong electron-absorbing effect changes the distribution of molecular electron clouds, strengthening carbon-fluorine bonds and increasing their stability to a certain extent. However, under extreme conditions such as specific strong nucleophiles or high temperatures, the carbon-fluorine bond may also be broken, resulting in changes in the compound.
Furthermore, methyl group is a power supply group, which can affect the electron cloud density of the pyridine ring, increase the electron cloud density on the ring, or increase its electrophilic substitution reactivity, and affect the stability in some reactions.
Under normal circumstances, if there is no active reagent or extreme conditions, 2-amino-5-fluoro-3-methyl pyridine can remain relatively stable. However, when high temperatures, strong acids, strong bases or strong oxidants, reducing agents, etc., its stability will be challenged, and the molecular structure may change, resulting in changes in chemical properties. Therefore, its stability depends on the environmental conditions, and it is impossible to generalize whether it is absolutely stable or not.

The synthesis method of 2-amino-5-fluoro-3-methylpyridine has been known for a long time, and is described in detail below.
First, fluoropyridine derivatives are used as starting materials. Find a suitable fluoropyridine, and the location of the fluorine atom in its structure needs to meet the requirements of the target molecule. In an appropriate reaction vessel, add this fluoropyridine, and dissolve it in a specific organic solvent to create a suitable reaction environment. Then add methylating reagents, such as iodomethane, and use a strong base as a catalyst, such as sodium hydride. Control the reaction temperature and duration, this process is like the control of the temperature, which is about success or failure. Under the catalysis of the base, the methyl group of the methylation reagent, such as the smart bird, falls precisely at a specific position on the pyridine ring, resulting in the formation of 3-methyl-5-fluoropyridine derivatives. This derivative is then aminated to introduce an amino group. Suitable amination reagents can be selected, such as ammonia under high temperature and pressure and assisted by a catalyst, to successfully connect the amino group to obtain 2-amino-5-fluoro-3-methylpyridine.
Second, 3-methylpyridine is used as the initial product. First, 3-methylpyridine is halogenated to introduce fluorine atoms skillfully. 3-Methylpyridine is placed in a halogenation reaction system, and fluorinated halogenating reagents such as N-fluorobisphenylsulfonamide are added. Under appropriate reaction conditions, fluorine atoms will selectively replace specific hydrogen atoms on the pyridine ring to generate 5-fluoro-3-methylpyridine. Subsequent to the amination step, similar to the above, suitable amination means can be used, such as aminolysis reaction. Under suitable reaction conditions, amino groups are successfully introduced into the two positions of the pyridine ring, and finally 2-amino-5-fluoro-3-methylpyridine is synthesized.
Third, through the heterocyclic construction method. Select suitable non-pyridine raw materials, such as nitrogen-containing, fluorine-containing and methyl-containing small molecule compounds. After multi-step reaction, the pyridine ring is first constructed. Using organic synthesis skills, such as nucleophilic substitution, cyclization reaction, etc. Step by step splicing each atom to construct a pyridine ring structure, and during the construction process, fluorine atoms, methyl and amino groups are cleverly landed at the target position, carefully carved, and finally a pure 2-amino-5-fluoro-3-methyl pyridine is obtained.

I look at your question, and I am inquiring about the price range of 2-amino-5-fluoro-3-methylpyridine in the market. However, the price of this chemical cannot be generalized, and it varies due to many reasons.
First, purity is the key. If the purity is extremely high, it is close to high-purity reagent grade, and it is suitable for high-demand fields such as fine synthesis and pharmaceutical research and development, and its price is high. Due to the complicated purification process and high cost, the price per gram may reach tens or even hundreds of yuan.
Second, the purchase volume also has an impact. If it is for a small amount of laboratory use, in grams, the merchant may price it slightly higher due to factors such as packaging and transportation costs. However, if a large number of purchases are made, in kilograms or even tons, the unit price may drop significantly due to scale effects, ranging from hundreds to thousands of yuan per kilogram.
Third, market supply and demand also determine its price. If there is a strong demand for this product at a certain time, but the supply is limited, the price will rise; conversely, if the supply exceeds demand, the price may decline.
Fourth, the source is different from the brand. Imported well-known brands often have higher prices than domestic brands due to quality control, R & D investment, etc. The price of domestic brands may be closer to the people, but the quality also varies.
In summary, laboratory purchases are small, with high purity, 20-100 yuan per gram; large industrial purchases are 500-5,000 yuan per kilogram. However, the market situation changes, this is only a rough estimate. For the exact price, please consult the chemical reagent supplier or relevant trading platform.