2-Amino-5-fluoro-3-bromopyridine

2-Amino-5-fluoro-3-bromopyridine is a key intermediate in organic synthesis and has crucial uses in many fields such as medicine and pesticides.
In the field of medicine, its role is particularly significant. Many new drugs are developed based on this raw material. Due to its unique chemical structure, it can participate in the construction of drug molecules and endow drugs with specific biological activities and pharmacological properties. For example, in the synthesis of some anti-cancer drugs, 2-amino-5-fluoro-3-bromopyridine can precisely combine with other compounds to form drug molecules with targeted anti-cancer ability, which can effectively inhibit the growth and spread of tumor cells. For example, in the development of antibacterial drugs, it can be used as a key structural unit to enhance the inhibition and killing effect of drugs on bacteria, providing powerful weapons for human beings to fight bacterial infections.
In the field of pesticides, 2-amino-5-fluoro-3-bromopyridine is also indispensable. The pesticides synthesized with this intermediate have the characteristics of high efficiency, low toxicity and environmental friendliness. For example, the preparation of some new pesticides, using their structural characteristics, can make pesticides more selective and lethal to pests, while protecting crops from pest attacks, while minimizing the impact on the environment and non-target organisms. In the research and development of herbicides, it can also play a unique role in helping to develop more accurate and effective herbicide products, and improve the efficiency and quality of agricultural production.
In summary, 2-amino-5-fluoro-3-bromopyridine is of great significance to human health protection and sustainable agricultural development due to its wide and critical application in the field of medicine and pesticides.

2-Amino-5-fluoro-3-bromopyridine is an organic compound with important uses in the field of organic synthesis. The physical properties of this compound are worth exploring, as follows:
- ** Properties **: Under normal conditions, 2-amino-5-fluoro-3-bromopyridine is mostly white to pale yellow crystalline powder. Its powder texture is delicate, and it occasionally shimmers in light, just like fine stars scattered in it. This appearance characteristic makes it unique among many compounds, providing an intuitive basis for experimenters to initially identify. < Br > - ** Melting point **: The melting point of this compound is about 120-125 ° C. As an important physical constant of a substance, the melting point is like its inherent "temperature label". When the temperature gradually rises to the melting point range, the lattice structure of 2-amino-5-fluoro-3-bromopyridine is thermally impacted, and the molecular thermal motion intensifies. The solid-state ordered structure gradually disintegrates, and finally melts into a liquid state. This process is precise and iconic.
- ** Boiling point **: The boiling point is roughly in the range of 270-280 ° C. The boiling point is of great significance. When the temperature rises to this point, the internal vapor pressure of the compound reaches equilibrium with the external atmospheric pressure, and a large number of molecules break free from the liquid phase and transform into the gas phase. This temperature range reflects the thermal stability and volatility of the compound, providing a key reference for its heating reaction or separation and purification operations.
- ** Solubility **: 2-Amino-5-fluoro-3-bromopyridine exhibits unique solubility in organic solvents. It can be moderately dissolved in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In dichloromethane, with stirring, the compound gradually disperses and dissolves to form a clear or microstrip homogeneous solution. In water, its solubility is relatively poor and only slightly soluble. This difference in solubility is due to the interaction between the molecular polarity of the compound itself and the polarity of the solvent, which is of great significance for the selection of suitable reaction solvents and the separation and purification method.
- ** Density **: The density is about 1.8 - 1.9 g/cm ³. The density is like the "weight mark" of the substance, reflecting the mass of the substance contained in the unit volume. This value indicates that the relative density of 2-amino-5-fluoro-3-bromopyridine is relatively large. In the experimental operation or mixing system, its density characteristics affect the distribution and mixing uniformity of the substance, which needs special consideration in practical application.

The synthesis method of 2-amino-5-fluoro-3-bromopyridine has always been the most important in the field of organic synthesis. The common methods for synthesizing this compound have several ends.
First, it can be prepared by halogenation and amination of compounds containing pyridine rings. First, take appropriate pyridine derivatives, and under specific conditions, brominate with brominating reagents, introducing bromine atoms at the third position of the pyridine ring. Commonly used brominating reagents, such as bromine, N-bromosuccinimide (NBS), etc. When reacting, pay attention to factors such as reaction temperature and solvent selection. After bromination is completed, fluorination is carried out, and fluorine atoms are introduced at the fifth position. The fluorination reagent can be selected from specific fluorine-containing compounds and is achieved according to the appropriate reaction path. Finally, the amination reaction is carried out to connect the amino group at the 2 position. There are various amination methods, and suitable amination reagents and conditions can be selected according to the specific situation.
Second, the pyridine ring can also be gradually constructed from simple raw materials and each substituent can be introduced. For example, small molecules containing nitrogen, carbon, fluorine, etc. are used as starting materials to form pyridine rings by cyclization reaction. During the cyclization process, the reaction conditions and raw material structure are cleverly designed so that bromine, fluorine, and amino groups can be connected to the desired position in sequence. This approach requires precise control of the reaction mechanism and reaction conditions at each step in order to obtain the target product.
Or, we can learn from the existing methods in the literature and optimize them. In many chemical research literature, there are many reports on the synthesis of related pyridine derivatives. You can refer to the synthesis route of similar structural compounds, and adjust the reaction conditions and reagents according to the characteristics of 2-amino-5-fluoro-3-bromopyridine to achieve the purpose of optimizing the synthesis. In short, to synthesize this compound, it is necessary to comprehensively consider the availability of raw materials, the complexity of reaction steps, and the high and low yield, and choose an appropriate method.

The price of Wuguanfu 2 - Amino - 5 - fluoro - 3 - bromopyridine on the market is difficult to determine. This compound is a commonly used raw material for organic synthesis, and its price often varies due to various factors.
First, it is related to purity. If its purity is extremely high, almost perfect, and reaches the purity of scientific research, it must be expensive. Because those who want to obtain this high purity require exquisite methods, complicated processes, and huge amounts of capital and effort, the price may be tens of gold per gram, or even hundreds of gold.
Second, the yield is also the main factor. If there is a sufficient supply of this product on the market, and there are many people who produce it, its price will be flat. If a business wants to compete in the market, it must compete for customers based on the price. However, if the output is scarce, or the raw materials are rare and the preparation is difficult, the price will be high. Or more than 100 gold per gram, also unknown.
Third, changes in the current situation, such as the price of raw materials, the tightness of policies, and the obstruction of transportation, can affect the price. If the price of raw materials rises, the cost of preparation increases, and the price also rises; if the policy is strict, the production is limited, the supply is small and the price is high; if the transportation is inconvenient, the cost increases, and the price also follows.
Judging from past market conditions, the price may hover between tens of yuan and hundreds of yuan per gram. However, the market is volatile and the price is indeterminate. If you want to know the real-time price, you should consult a chemical raw material supplier or a professional chemical trading platform to obtain the exact number.

2-Amino-5-fluoro-3-bromopyridine is a kind of organic compound. Its storage conditions are of paramount importance, which is related to the stability and quality of this substance.
This substance should be stored in a cool, dry and well-ventilated place. In a cool environment, it can avoid chemical reactions caused by high temperature or decomposition and deterioration due to heat. Dry conditions can prevent moisture from invading, covering moisture or triggering adverse reactions such as hydrolysis, which can damage the structure and properties of the compound. Well-ventilated, it can disperse volatile gases that may accumulate, avoid its concentration being too high and causing safety hazards, and keep the air in the storage environment fresh and prevent impurities from mixing.
Furthermore, keep away from fire and heat sources. Both fire and heat sources can provide energy, causing 2-amino-5-fluoro-3-bromopyridine molecules to be active, or causing dangers such as combustion and explosion. It should also be stored separately from oxidants, acids, bases, etc., because of its active chemical properties, contact with such substances, or cause violent chemical reactions, endangering safety.
Storage containers are also particular. Use sealed containers to prevent air, moisture and other impurities from entering. Choosing containers of suitable materials, such as corrosion-resistant glass or specific plastic materials, can ensure that the container does not interact with 2-amino-5-fluoro-3-bromopyridine to maintain its purity and stability. During daily storage, it is also necessary to check regularly to see if there is any leakage, deterioration, etc. If there is any abnormality, dispose of it in time to ensure storage safety and the quality of the compound.