2-Amino-5-chloro-3-methylpyridine

2-Amino-5-chloro-3-methylpyridine is widely used in the field of organic synthesis.
First, for the preparation of pesticides, this compound can be a key intermediate. If a new type of insecticide is created, due to its unique structure, a molecular structure with high insecticidal activity can be constructed through a series of reactions. In the research and development of modern pesticides, there is a growing demand for highly selective, low-toxicity and environmentally friendly agents for pests. Due to its chemical properties, 2-amino-5-chloro-3-methylpyridine can meet part of the needs of this research and development direction. By reacting with other organic reagents, different functional groups can be derived to optimize the mechanism of action and activity of pesticides.
Second, it also has important functions in the field of medicinal chemistry. The synthesis of many drug molecules relies on it as a starting material or intermediate. Scientists hope to use its pyridine ring and the characteristics of the linked amino group, chlorine atom and methyl group to design and synthesize compounds with specific pharmacological activities, such as antibacterial and anti-inflammatory drugs. The presence of the pyridine ring endows the molecule with certain stability and biological activity, and the linked substituents can adjust the interaction between the drug and the target, and improve the efficacy and selectivity of the drug.
Furthermore, in the field of materials science, 2-amino-5-chloro-3-methylpyridine can participate in the preparation of special functional materials. For example, the synthesis of organic materials with specific optical and electrical properties is used in the field of optoelectronics. Its structure can be chemically modified to regulate the energy level structure and charge transport properties of materials, providing a new way for the research and development of organic Light Emitting Diodes, solar cells and other materials.
In summary, 2-amino-5-chloro-3-methylpyridine has important uses in pesticides, medicine, materials and other fields due to its unique chemical structure, and has made great contributions to the development of related fields.

2-Amino-5-chloro-3-methylpyridine, an organic compound, is widely used in chemical, pharmaceutical and other fields. Its physical properties are particularly important, and are described as follows:
First appearance, under room temperature and pressure, 2-amino-5-chloro-3-methylpyridine is often in the shape of white to light yellow crystalline powder, with fine texture and uniform powder. This appearance characteristic can be used as the primary basis for actual operation and identification.
The melting point is about 116-118 ° C. Melting point is one of the important physical properties of a substance, and it is of great significance to determine the purity of the compound. If the measured melting point is in good agreement with the established range, it can usually be proved that the purity is high; if the melting point deviation is significant, it may contain impurities and needs to be further purified.
Furthermore, the boiling point is the boiling point, but the exact boiling point information is relatively scarce. However, in general, the boiling point of organic compounds is affected by various factors such as intermolecular forces and molecular weight. 2-Amino-5-chloro-3-methylpyridine contains groups such as amino groups, chlorine atoms and methyl groups due to its specific molecular structure, resulting in the uniqueness of intermolecular forces, which in turn affects the boiling point. Although there is no precise value, it can be inferred from similar structural compounds that its boiling point or higher temperature range.
In terms of solubility, the compound is slightly soluble in water. This is because water is a polar solvent, and although 2-amino-5-chloro-3-methylpyridine contains polar amino groups, the presence of chlorine atoms and methyl groups reduces the polarity of the molecule to a certain extent, making it difficult to achieve a soluble degree of force between it and water molecules. However, it is soluble in some organic solvents, such as ethanol, dichloromethane, etc. Ethanol has moderate polarity and hydrogen bonding, and can form intermolecular forces with 2-amino-5-chloro-3-methylpyridine to promote dissolution; although dichloromethane has weak polarity, there is a van der Waals force between the molecules of this compound, and it can also achieve a certain degree of mutual dissolution.
In addition, 2-amino-5-chloro-3-methylpyridine also has a certain smell, and its smell is special, which is usually smelled or uncomfortable by people. When handling this substance, due to its odor and potential toxicity, it needs to be carried out in a well-ventilated environment to prevent harm to the human body.
In summary, the physical properties of 2-amino-5-chloro-3-methylpyridine, such as appearance, melting point, solubility, and odor, are of critical significance for its application, storage, and operation in various fields.

2-Amino-5-chloro-3-methylpyridine, a family of organic compounds, is of great significance in the field of chemistry. Its chemical properties are unique, determined by the amino group, chlorine atom and methyl group contained in its structure.
Amino group, with nucleophilic properties, can cause this compound to participate in many nucleophilic substitution reactions. In the case of halogenated hydrocarbons, the nitrogen atom of the amino group is willing to provide electron pairs to bond with the carbon atom of the halogenated hydrocarbon to generate substitution products. This property is very useful in the construction of complex organic molecular structures, which can be used to introduce other functional groups and expand the diversity of molecules.
The chlorine atom in this compound also has a deep impact. Although its high electronegativity decreases the electron cloud density of ortho and para-site, and the activity of electrophilic substitution reaction is slightly reduced, under certain conditions, chlorine atoms can act as leaving groups. When encountering strong nucleophiles, chlorine atoms will leave and be replaced by nucleophiles. This reaction is often a key step in the synthesis of new pyridine derivatives.
Furthermore, the addition of methyl groups to the pyridine ring slightly increases the electron cloud density of the pyridine ring due to the electron-pushing effect. This has a great impact on the localization effect of the electrophilic substitution reaction, guiding the electrophilic reagents to attack specific locations. And the presence of methyl groups changes the spatial configuration and physical properties of molecules, such as melting point, boiling point and solubility. Usually, the introduction of methyl groups will slightly increase the lipid solubility of molecules, which is related to the absorption and distribution of compounds in vivo in some organic synthesis or drug development.
2-Amino-5-chloro-3-methylpyridine is rich in chemical properties. By rationally using its functional group properties, chemists can use it to synthesize multiple organic compounds, and has considerable application potential in pharmaceutical chemistry, materials science and other fields.

The preparation method of 2-amino-5-chloro-3-methylpyridine is a key task in the field of chemical synthesis. In the past, several paths were often followed to prepare this compound.
One is to use a suitable pyridine derivative as the starting material. If a pyridine containing a specific substituent is selected, it undergoes a halogenation reaction to introduce chlorine atoms in the appropriate position. Under specific reaction conditions, a halogenated reagent interacts with a pyridine derivative, in which the reaction temperature, solvent and catalyst all need to be precisely regulated. After the halogenation is completed, the amination reaction is carried out. Ammonia or ammonia derivatives are often used as amination reagents. In a suitable alkaline environment and reaction conditions, amino groups can be introduced by substituting the groups in the corresponding positions. However, in this process, the control of reaction selectivity and yield is quite challenging, and the reaction conditions of each step need to be carefully optimized.
Second, there is also a strategy of constructing pyridine rings through multi-step reactions. First, small molecule compounds containing carbon and nitrogen atoms are used as raw materials, and the pyridine ring structure is constructed through a series of reactions such as condensation and cyclization. In the process of constructing pyridine rings, substituents such as methyl and chlorine atoms are introduced at the same time. For example, through a specific condensation agent and the reaction substrate, at an appropriate temperature and reaction time, the intermolecular condensation reaction is promoted to form a pyridine ring. Later, according to the needs, the pyridine ring is further modified, such as amination and other reactions, and finally 2-amino-5-chloro-3-methylpyridine is obtained. Although this path is complicated in steps, it may have unique advantages in the selection of raw materials and the selective regulation of the reaction.
Or there are other preparation methods, such as the reaction catalyzed by transition metals. The unique activity and selectivity of transition metal catalysts are used to realize the functionalization reaction at a specific location. In the presence of suitable transition metal catalysts, the substrate reacts with the corresponding reagents, and chlorine atoms, amino groups and other groups are precisely introduced. This method often requires careful screening and optimization of catalysts, ligands and reaction conditions to achieve the desired reaction effect. In short, there are various methods for preparing 2-amino-5-chloro-3-methylpyridine, each with its own advantages and disadvantages. In actual production, it is necessary to comprehensively consider many factors such as raw material availability, cost, yield and product purity, and carefully select the appropriate preparation method.

2-Amino-5-chloro-3-methylpyridine is in the market, and its price range is difficult to determine. The price of this compound often varies due to various factors. First, the yield is the key. If it is widely produced and the market supply is abundant, the price may decrease; if it is thin, the supply is less and the demand is more, the price will rise.
Furthermore, the quality also affects the price. Those who are of high quality are in line with the high standard, and the price is often not cheap; those who are of poor quality, the price may decrease.
The source also affects its price. Direct purchase from the producer, no intermediary fee, the price or appropriate; through repeated changes of hands, the cumulative cost will increase, and the price will increase.
The need for the market is also the main reason. The industry is prosperous, such as pharmaceutical, chemical research and development and other fields, and the price may rise; if there is no big demand, the price may be stable or drop.
According to past market prices, the price of 2-amino-5-chloro-3-methylpyridine per kilogram may be between tens of yuan and hundreds of yuan. However, this is only a rough number. The market situation is changing rapidly, and the current price is different from the past. It is difficult to determine the current price range. For accurate pricing, it is advisable to consult chemical raw material suppliers, traders, or refer to professional chemical market information platforms to obtain real-time quotes.