2-Amino-5-chloro-3-fluoropyridine

2-Amino-5-chloro-3-fluoropyridine is an important organic compound that is useful in various fields.
First, in the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to the unique structure of the pyridine ring, the compound is endowed with special biological activity. Based on this, chemists can use various chemical reactions to add different functional groups, thereby creating new drugs with specific pharmacological effects. For example, through careful design and reaction, antibacterial, antiviral and even anti-tumor drugs can be prepared to treat various diseases and benefit human health.
Second, in the field of pesticide chemistry, 2-amino-5-chloro-3-fluoropyridine also plays an important role. With this as a raw material, efficient and low-toxic pesticides can be synthesized. Its structural characteristics may make the pesticide produced highly selective and highly active to specific pests or weeds, which can not only effectively prevent and control crop diseases and insect pests, but also ensure crop yield and quality, and reduce environmental pollution and impact on non-target organisms, meeting the needs of current green agriculture development.
Furthermore, in the field of materials science, this compound may be used to prepare materials with special functions. Through its combination or reaction with other substances, it can endow materials with unique electrical, optical or mechanical properties, which can be used in electronic devices, optical materials and many other aspects to promote the development and innovation of materials science.
In summary, 2-amino-5-chloro-3-fluoropyridine has shown important application value in many fields such as medicine, pesticides, materials and other fields due to its unique structure and properties, and has made great contributions to the progress of related industries.

2-Amino-5-chloro-3-fluoropyridine is an organic compound with specific physical properties. It is a white to quasi-white solid, which is solid at room temperature. The molecules are closely arranged due to intermolecular forces. The melting point range is about 130-135 ° C. When heated to this temperature range, the molecules are able to break free from the lattice and melt from the solid state into a liquid state.
The compound has unique solubility and is slightly soluble in water. Because its molecules contain pyridine rings and amino, chlorine, fluorine and other substituents, although the amino group can form hydrogen bonds with water, the hydrophobicity of the pyridine ring and the halogen atom results in limited overall water solubility. However, it can be better dissolved in common organic solvents, such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. In dichloromethane, due to the Van der Waals force and weak interaction between molecules and dichloromethane, it can be uniformly dispersed to form a solution, which is essential for the separation and purification steps of organic synthesis.
2-amino-5-chloro-3-fluoropyridine has a certain stability and can exist stably at room temperature and pressure. However, when encountering strong oxidizing agents, strong acids or strong bases, amino groups, halogen atoms and pyridine rings in its structure may participate in the reaction. In case of strong acids, amino groups are easily protonated; in case of strong bases, halogen atoms may undergo substitution or elimination reactions. It is usually stable in organic solvents, providing convenience for use as an intermediate in organic synthesis.
Because it contains multiple activity check points, it has important applications in the field of organic synthesis. Amino, chlorine and fluorine atoms can all be converted into other functional groups through different chemical reactions to build complex organic molecular structures, which has broad prospects in the synthesis of fine chemicals such as pharmaceuticals and pesticides.

To prepare 2-amino-5-chloro-3-fluoropyridine, the common synthesis methods are as follows.
First, a compound containing a pyridine structure is used as the starting material. You can first take a suitable pyridine derivative, which has a modifiable group on the pyridine ring. For example, choose a pyridine halide, have a halogen atom at a specific position in the pyridine ring, and introduce an amino group by means of a nucleophilic substitution reaction. In this process, the reaction conditions and reagents need to be carefully selected. Ammonia or amine compounds are often used as amino donors. In suitable solvents, such as alcohols or polar aprotic solvents, suitable bases, such as potassium carbonate and sodium carbonate, are added to promote the reaction. And it is necessary to pay attention to the control of the reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions to occur, which will affect the purity and yield of the product.
Second, it can also be achieved by the strategy of constructing a pyridine ring. A multi-step reaction can be used to synthesize a chain or cyclic intermediate containing a specific substituent first, and then form a pyridine ring through a cyclization reaction. For example, using β-ketone esters, amines, and halogenated hydrocarbons as raw materials, pyridine rings are formed through multi-step condensation and cyclization. In such methods, the order and conditions of each step of the reaction are crucial. Each step of the reaction requires fine regulation of the ratio of reactants, reaction temperature, catalyst and other factors, so that the reaction can proceed in the desired direction, successfully construct a pyridine ring, and precisely introduce chlorine, fluorine and amino groups into the ring.
In addition, transition metal catalysis can also be used. Transition metal catalysts, such as palladium, copper and other complexes, catalyze the coupling reaction between halogenated pyridine and amino-containing reagents. Such methods usually have high selectivity and reaction efficiency. However, due to the high cost of transition metal catalysts and the sensitivity of the reaction system to impurities, the raw materials and solvents must be strictly purified before the reaction, and the reaction conditions, such as reaction temperature, ligand selection and dosage, must be precisely controlled to ensure the smooth progress of the reaction and efficient synthesis of 2-amino-5-chloro-3-fluoropyridine.

2-Amino-5-chloro-3-fluoropyridine is in the market, and its price range is difficult to determine. The price of this compound often changes for many reasons.
First, the amount of quantity has a significant effect on its price. If the purchase quantity is wide, the price per unit may be cheaper. If mass production and sales are covered, the unit cost can be reduced. Merchants are also willing to offer preferential prices to big customers, hoping to increase sales and promote revenue.
Second, the quality of the quality is also one of the reasons for the price. For high quality, the production process may require more refined craftsmanship and stricter quality control, and the cost will increase, and the price will follow. And the lesser one, although it can be used for part of the foundation, the price may be slightly lower due to poor quality.
Third, the supply and demand of the city also affect the price. If there are many applicants, and the supply is limited, the price will rise; on the contrary, if the supply exceeds the demand, the merchant will sell the goods, or reduce the price.
Fourth, the place of origin also has an impact. Different origins, due to differences in raw material costs, labor costs, and transportation expenses, the price of this compound varies.
Looking at past transactions, the price of 2-amino-5-chloro-3-fluoropyridine varies from a few yuan to tens of yuan per gram. However, this is only an approximate figure, and the actual price shall be subject to the current market conditions and specific transaction conditions. To know the exact price, you need to consult the relevant suppliers and investigate the details of quantity, quality, delivery terms, etc., before you can know the exact price.

2-Amino-5-chloro-3-fluoropyridine is an organic compound. During storage and transportation, many matters must be paid attention to.
Dry storage environment. This compound is susceptible to water vapor. If the environment is humid, or it causes reactions such as hydrolysis, it will damage the quality. Therefore, it should be stored in a dry, well-ventilated place and in a sealed container to prevent the intrusion of water vapor.
Time and temperature control. High temperature may cause it to decompose, deteriorate, or increase reactivity, causing danger. It should be stored in a cool place, usually at 2-8 ° C, depending on its physicochemical properties and relevant instructions.
In addition, avoid contact with oxidants, acids, bases and other substances. The structure of 2-amino-5-chloro-3-fluoropyridine contains amino groups, chlorine atoms and fluorine atoms. In case of oxidants, or oxidation reactions; in case of acids and bases, or substitution, addition and other reactions, the composition and properties can be changed.
When transporting, the packaging must be sturdy. Make sure that the packaging is not damaged or leaked during handling. Choose suitable packaging materials, such as glass bottle jacket buffers, or special plastic containers, to protect it.
Strictly abide by transportation regulations. Because it may belong to the category of hazardous chemicals, the transporter needs to have corresponding qualifications, complete transportation documents, and clear product names, properties, hazards and emergency measures to prepare for inspection and response to emergencies. In this way, 2-amino-5-chloro-3-fluoropyridine is safe in storage and transportation.