2 Amino 5 Carboxypyridine
pyridine pyrrole pyrazine piperidine piperazine

2-Amino-5-carboxypyridine

    Specifications

    HS Code

    493040

    Chemical Formula C6H6N2O2
    Molar Mass 138.124 g/mol
    Appearance Solid (usually white or off - white)
    Solubility In Water Moderately soluble
    Melting Point Around 220 - 225 °C
    Boiling Point Decomposes before boiling
    Pka Value For Carboxyl Group ~2.5 - 3.5
    Pka Value For Amino Group ~9 - 10
    Odor Odorless or very faint odor
    Density Approximately 1.4 - 1.5 g/cm³
    Crystal Structure May form orthorhombic or monoclinic crystals
    Uv Vis Absorption Absorbs in the ultraviolet region

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    General Information
    Where to Buy 2-Amino-5-carboxypyridine in China?
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    Frequently Asked Questions

    As a leading 2-Amino-5-carboxypyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Amino-5-carboxypyridine?
    2-Amino-5-carboxylpyridine, this substance has a wide range of uses. In the field of medicine and chemical industry, it is an important raw material for organic synthesis. It can be used as an intermediate to create various drugs. Because the molecule has amino and carboxyl groups, it can be chemically reacted to construct complex drug molecules by means of organic synthesis, or provide key structural units for drugs to treat specific diseases.
    In the field of materials science, it also has its uses. Its specific structure gives materials unique properties, such as participating in polymerization reactions, generating polymer materials with special functions, or used to prepare functional materials with adsorption or recognition ability for specific substances.
    In scientific research experiments, it is also a commonly used reagent. Scientists use its unique chemical properties to explore organic reaction mechanisms, providing assistance for the development of new reaction pathways and synthesis methods. Or used to catalyze certain chemical reactions, with its structure and activity, to improve reaction efficiency and selectivity.
    In short, 2-amino-5-carboxypyridine has important uses in many fields such as medicine, materials and scientific research. With the advancement of science and technology and the deepening of research, its potential applications are expected to be further expanded.
    What are the physical properties of 2-Amino-5-carboxypyridine?
    2-Amino-5-carboxylpyridine is a class of organic compounds. Its physical properties are quite important and are of key significance in many fields.
    Looking at its properties, under normal temperature and pressure, it is mostly in solid form. This morphological characteristic makes it necessary to consider specific conditions during storage and transportation to prevent deterioration or damage. In addition, its color is usually white to light yellow, and this color characteristic may be used as a basis for preliminary identification.
    Melting point is also a key physical property. After many experiments, its melting point is about a specific range, and this melting point data is of great significance for the purification and identification of compounds. Knowing the melting point, the purity of the compound can be determined by means of melting point determination. If the melting point deviates from the established range, or implies that it contains impurities.
    Solubility is also a property that cannot be ignored. In water, 2-amino-5-carboxypyridine has a certain solubility, but its solubility is not very high. In organic solvents, such as ethanol, acetone, etc., its solubility is different. In ethanol, the solubility is relatively good. This difference in solubility provides an important reference for the separation, purification and selection of solvents for chemical reactions.
    In addition, the compound also has a certain degree of hygroscopicity. In a humid environment, it is easy to absorb moisture in the air, which requires that when storing, attention should be paid to the drying of the environment to prevent its chemical properties and performance from being affected by moisture absorption.
    The above physical properties, such as properties, color, melting point, solubility and moisture absorption, are related and affected, and together determine the performance and treatment of 2-amino-5-carboxypyridine in practical applications. It is an indispensable consideration in chemical research, industrial production and many other aspects.
    What is the chemistry of 2-Amino-5-carboxypyridine?
    2-Amino-5-carboxylpyridine, this is an organic compound. Its properties are related to many chemical characteristics.
    First of all, its acidity and alkalinity. The carboxyl group is acidic and can release protons in a suitable environment, while the amino group is basic and can accept protons. This amphoteric trait makes it appear in different ion forms in different pH media, which affects its solubility and reactivity. In acidic media, amino groups are easily protonated to form positively charged ions; in alkaline media, carboxyl groups dissociate to form negatively charged ions.
    In terms of solubility, because the molecule contains polar carboxyl groups and amino groups, it has a certain solubility in polar solvents such as water. However, its solubility is also affected by the pH of the environment. When the pH of the solution causes it to form an ionic state, the solubility is often better.
    The reaction activity is quite high. Amino groups can participate in many reactions, such as acylation with acyl halides, acid anhydrides, etc., to form amide derivatives; they can also condensate with aldides, ketones, etc., to obtain nitrogen-containing heterocycles or other complex structures. Carboxyl groups can also be esterified with alcohols to form ester compounds; they can also react with bases to form salts.
    In addition, the conjugated structure of the pyridine ring endows it with certain stability and electronic effects. The distribution of electron clouds on the ring is affected by amino groups and carboxyl groups, making specific positions on the ring more prone to electrophilic or nucleophilic substitution reactions. For example, the positioning effect of amino and carboxyl groups can guide substituents into specific positions in the pyridine ring, resulting in the synthesis of derivatives with specific structures.
    2-amino-5-carboxylpyridine has rich and diverse chemical properties and has important uses in organic synthesis, medicinal chemistry and other fields, providing a broad space for the creation of novel compounds and the exploration of new reaction paths.
    What are 2-Amino-5-carboxypyridine synthesis methods?
    The synthesis method of 2-amino-5-carboxylpyridine has been investigated by many parties throughout the ages, and this is described in detail today.
    First, pyridine is used as the starting material, and this goal can be achieved through a multi-step reaction. Nitrify the pyridine first, and introduce the nitro group under suitable conditions. This process requires careful control of the reaction temperature, the proportion of reactants, and the reaction time in order to accurately locate the nitro group to the appropriate position and lay the foundation for subsequent conversion. The resulting nitropyridine is then reduced to an amino group by an appropriate reducing agent, such as a combination of metal and acid, or by catalytic hydrogenation, to obtain an amino-containing pyridine derivative. Then, using specific carboxylation reagents, carboxyl groups are introduced into the pyridine ring through suitable reaction mechanisms, such as nucleophilic substitution or electrophilic substitution, etc., and finally 2-amino-5-carboxypyridine is obtained.
    Second, some pyridine derivatives can also be used as starters. If the starter already has some of the required functional groups, such as the similar structure of amino or carboxyl groups, it can be modified and transformed through selective reactions according to the characteristics of functional groups. For example, through the protection and deprotection strategies of existing functional groups, various organic reactions such as esterification, hydrolysis, oxidation, reduction, etc. are skillfully used to gradually construct the structure of the target molecule. In this process, the control of the reaction conditions is particularly critical. A little carelessness may lead to the occurrence of side reactions, affecting the purity and yield of the product.
    Third, some novel synthesis technologies and concepts can also be used. For example, green synthesis methods developed in recent years pursue high efficiency, environmental protection and sustainability of the reaction. By selecting green solvents and catalysts, the reaction path can be optimized, waste generation can be reduced, and atomic utilization can be improved. These methods not only meet the current needs of environmental protection, but also open up a new path for the synthesis of 2-amino-5-carboxypyridine, which is expected to shine in future research and production.
    What is the price range of 2-Amino-5-carboxypyridine in the market?
    The price of 2-amino-5-carboxylpyridine in the market is difficult to determine. The price often changes due to various reasons, such as differences in producers, quality, and supply conditions.
    Looking at the market conditions in the past, if the purchase is from ordinary merchants, the quantity is not huge, and the price per gram may be around tens of yuan to hundreds of yuan. However, if the purchase quantity is quite large, the price may be reduced to between 20 yuan and 50 yuan per gram, which also varies depending on the quantity.
    In addition, the quality of its coarse quality also has a great impact on the price. If it is a high-purity product, suitable for special needs, the price must be high, or more than 100 yuan per gram. If the quality is only suitable for ordinary use, the price is slightly lower.
    The demand for supply should not be ignored. If you ask for more and less, the price will rise; if the supply exceeds the demand, the price may fall. In order to know the exact price, those who should consult the merchants at the time can compare the price before they can get a suitable price.