2-amino-5-bromopyridine-3-carboxylic acid

2-Amino-5-bromopyridine-3-carboxylic acid, this substance has a wide range of uses. In the field of medicine, it is an important intermediate in organic synthesis. Many drug development requires this as the basic raw material. Through specific chemical reactions, ingenious steps and precise conditions, compounds with complex structures and specific pharmacological activities can be constructed, which can be used to create new drugs and treat various diseases, such as anti-cancer drugs for specific targets, drugs for the treatment of nervous system diseases, etc.
In the field of pesticides, it is also indispensable. Using it as a starting material and carefully designed synthetic routes can prepare pesticide products with high insecticidal, bactericidal or herbicidal activities. Such pesticides can precisely act on the specific physiological processes of pests, inhibit their growth and reproduction, and achieve the purpose of controlling crop diseases and insect pests, ensuring crop yield and quality.
In addition, in the field of materials science, 2-amino-5-bromopyridine-3-carboxylic acid can participate in the synthesis of functional materials. By reacting with other compounds, materials are endowed with unique electrical, optical or mechanical properties, such as application in organic optoelectronic materials, improve the photoelectric conversion efficiency of materials, and contribute to the development of new optoelectronic devices. Its application in different fields depends on its unique molecular structure and chemical properties, making it a key component in many scientific research and industrial production processes.

There are many ways to synthesize 2-amino-5-bromopyridine-3-carboxylic acid. In the past, pyridine derivatives were used as the beginning, and they were prepared by halogenation, amination and carboxylation.
First take a suitable pyridine substrate, under the condition of halogenation, apply it with a brominating agent, such as bromine in an appropriate solvent and catalyst, the pyridine ring can be brominated at a specific position to obtain 5-bromopyridine derivatives. This step requires controlling the reaction temperature, time and material ratio to prevent side reactions from occurring and causing the formation of polybrominates.
Then, the 5-bromopyridine derivatives are aminated. Ammonia sources, such as liquid ammonia or organic amines, are often used in a specific reaction system, or catalyzed by transition metals, so that the amino group replaces the halogen atom in a suitable position to obtain 2-amino-5-bromopyridine. Among them, the choice of catalyst and the control of the reaction environment are all related to the efficiency and selectivity of amination.
Last rule, carboxylation reaction. Carboxyl groups can be introduced at specific positions of 2-amino-5-bromopyridine by means of metal-organic reagents, such as Grignard reagent or lithium reagent, and carbon dioxide, or other carboxylation methods, to obtain 2-amino-5-bromopyridine-3-carboxylic acid. < Br >
There are also other methods, such as using carboxyl-containing pyridine derivatives as the starting material, first carboxylation, then halogenation, and amination, but the order of steps and the control of conditions are different, all of which need to be carefully considered and optimized according to the actual situation, in order to achieve the purpose of efficient synthesis.

2-Amino-5-bromopyridine-3-carboxylic acid, an organic compound. It has many physical properties. This substance is solid under normal conditions, but the specific appearance may vary depending on the purity and preparation method, or it may be white to light yellow crystalline powder.
Regarding the melting point, due to intramolecular hydrogen bonds and intermolecular forces, the melting point is quite high, about 250-260 ° C. This high melting point makes it stable at general ambient temperatures and does not melt easily.
In terms of solubility, its solubility in water is limited. Due to the presence of polar carboxyl groups and amino groups in this compound, it should interact with water to a certain extent; however, the presence of pyridine rings and bromine atoms reduces its hydrophilicity. However, in polar organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc., the solubility is relatively good.
The density of 2-amino-5-bromopyridine-3-carboxylic acid is also an important physical property. Although the exact value varies depending on the measurement conditions, its density is slightly higher than that of water. This property makes it possible to design the corresponding separation process when it comes to liquid-solid or liquid-liquid separation operations.
In addition, the compound has a certain degree of hygroscopicity. Water vapor in the air easily interacts with its polar groups, causing it to absorb water. Care should be taken to prevent moisture during storage to maintain its purity and stability.
The physical properties of this compound are of great significance in the fields of organic synthesis, medicinal chemistry, etc. During synthesis, properties such as melting point and solubility help to select appropriate reaction conditions and separation and purification methods. In drug development, these properties affect the design of drug formulations and the processes of absorption and distribution in vivo.

In today's world, the business situation is complicated, and it is difficult to hide the market price of 2-amino-5-bromopyridine-3-carboxylic acid. The price fluctuation often depends on many factors.
The source of raw materials is one of them. If the raw materials required for its preparation are easily obtained and the supply is stable, the cost is controllable and the price may stabilize. On the contrary, if the raw materials are scarce, or their origin changes and the supply is not smooth, the price will rise.
The difficulty of the preparation process also affects the price. If the preparation method is simple, energy consumption is low, and the yield is high, the price may be low; if the process is complicated, high-end equipment and professional technology are required, and the yield is limited, the price should be high.
The amount of market demand is more critical. If this acid is in strong demand in the fields of medicine, chemical industry, etc., and the supply exceeds the demand, the merchant will raise the price to make a profit; if the demand is low and the inventory is overstocked, the merchant will clear the goods or reduce the price for promotion.
According to past market conditions, the price range or fluctuation ranges from a few yuan to tens of yuan per gram. However, this is only a rough number. The actual price varies from time to time and from place to place, and the pricing strategies of each supplier are also different. For accurate prices, please consult chemical raw material suppliers, chemical trading platforms, etc., subject to real-time market conditions.

2-Amino-5-bromopyridine-3-carboxylic acid is a chemical substance. The important thing about its storage conditions should be careful.
This substance should be stored in a cool, dry and well-ventilated place. In a cool place, the temperature should not be too high. If it is too high, it may cause its chemical properties to change, such as the risk of decomposition and deterioration. Generally speaking, the storage temperature should not exceed [X] ° C, and the specific temperature should be determined according to its chemical properties. The dry environment is also the key. Moisture can easily cause it to get damp, or chemically react with water, which will damage its purity and quality. Therefore, the ambient humidity should be controlled below [X]%.
Furthermore, the substance should be kept away from fire and heat sources. Fire and heat sources can cause a sudden rise in temperature and cause unpredictable reactions, such as combustion, explosion and other dangerous situations. And it needs to be stored separately from oxidizing agents, acids, alkalis, etc. Because of its chemical activity, it coexists with them and is prone to chemical reactions, resulting in accidents.
When storing, the container must be well sealed to prevent leakage. If there is leakage, it will not only damage the substance itself, but also pollute the environment and endanger the safety of personnel. After taking it, it should also be sealed in time, returned to its original position, and strictly abide by the storage specifications. In this way, the quality and safety of 2-amino-5-bromopyridine-3-carboxylic acid can be guaranteed for subsequent use.