2-Amino-5-bromo-3-(trifluoromethyl)pyridine

2-Amino-5-bromo-3- (trifluoromethyl) pyridine, an organic compound, has important applications in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Through specific chemical reactions, its structure can be modified to synthesize many biologically active drug molecules. For example, in the development of new drugs for specific disease targets, the unique structure of 2-amino-5-bromo-3- (trifluoromethyl) pyridine can provide a key chemical check point, which helps to construct pharmacophore that fits the target, so as to achieve precise treatment of diseases.
In the field of pesticide chemistry, it also plays an important role. Due to its fluorine-containing atoms, pesticides synthesized from this raw material often have the characteristics of high efficiency, low toxicity, and environmental friendliness. By introducing it into the molecular structure of pesticides, the effect of pesticides on pests and pathogens can be enhanced, while reducing the harm to the environment and non-target organisms, contributing to the creation of high-efficiency green pesticides.
In the field of materials science, the compound also shows application potential. Its special chemical structure can participate in the synthesis of polymer materials, giving the materials unique properties, such as improving the thermal stability and chemical stability of the materials, providing a new way for the development of new functional materials.
In summary, 2-amino-5-bromo-3- (trifluoromethyl) pyridine, with its unique structure, plays an important role in the fields of medicine, pesticides, materials, etc., promoting the sustainable development and innovation of related fields.

The common methods for synthesizing 2-amino-5-bromo-3- (trifluoromethyl) pyridine are as follows.
One is to use a compound containing a pyridine ring as the starting material, which is prepared by a series of reactions such as halogenation and amination. The pyridine is first brominated to selectively introduce bromine atoms into a specific position. This step requires the selection of suitable brominating reagents and reaction conditions to achieve the ideal regioselectivity. Subsequently, the introduction of trifluoromethyl can be achieved by nucleophilic substitution or free radical reaction with suitable trifluoromethylating reagents. Finally, the amination reaction is carried out, and the amino group is introduced into the target position to obtain 2-amino-5-bromo-3- (trifluoromethyl) pyridine.
Second, the pyridine ring can be constructed by multi-step cyclization reaction from simple organic small molecules. First, the carbon chain structure containing bromine and trifluoromethyl is constructed with suitable reagents, and then the pyridine ring is formed by cyclization, and the amino group is introduced at the same time. This path requires precise regulation of the cyclization conditions to ensure the formation of pyridine rings and the desired position of each substituent.
Furthermore, the coupling reaction catalyzed by transition metals can also be used. Using different fragments containing bromine, amino group and trifluoromethyl as raw materials, under the action of transition metal catalysts, each fragment is precisely spliced through carbon-nitrogen, carbon-carbon coupling and other reactions, and then the target product is synthesized. This method requires high requirements for the selection of catalysts, the design of ligands and the optimization of reaction conditions, but it can achieve high-efficiency and high-selectivity synthesis.
When synthesizing this compound, it is necessary to comprehensively consider the availability of starting materials, the complexity of reaction steps, the yield and selectivity, etc., and carefully select an appropriate synthesis method to achieve the goal of efficient and economical synthesis.

2-Amino-5-bromo-3- (trifluoromethyl) pyridine is one of the organic compounds. Its physical and chemical properties are quite important and are related to many application fields.
Looking at its physical properties, under normal temperature and pressure, this substance is mostly in a solid state, but it also varies depending on specific conditions. The values of its melting point and boiling point are crucial in the separation, purification and application of substances. It is difficult to obtain accurate data, but it is conceivable that because its molecular structure contains bromine atoms and trifluoromethyl, it can enhance the intermolecular force, and the melting point, boiling point or higher than that of ordinary pyridine compounds.
As for chemical properties, due to the presence of amino groups, bromine atoms and trifluoromethyl groups on the pyridine ring, the chemical activity is quite strong. Amino groups have certain alkalinity and can react with acids to form corresponding salts. Bromine atoms are good leaving groups, which can participate in many nucleophilic substitution reactions, such as interacting with nucleophilic reagents such as alcohols and amines, introducing different functional groups to expand the application range of compounds. Trifluoromethyl, on the other hand, has strong electron absorption, which can affect the electron cloud density of the pyridine ring, reduce the electron cloud density on the ring, making it difficult for electrophilic substitution reactions to occur, but also enhance the stability and chemical inertness of the compound. At the same time, this structure may affect the solubility of the compound. Due to the hydrophobicity of trifluoromethyl, its solubility in organic solvents may be better than that in water.
The physical and chemical properties of this compound lay the foundation for its application in organic synthesis, medicinal chemistry and other fields. It can be used as an important synthesis intermediate to prepare various compounds with special properties.

Today there is a question, what is the price range of 2-amino-5-bromo-3- (trifluoromethyl) pyridine in the market. This is a compound in the field of fine chemicals, and its price often varies due to many factors.
The first to bear the brunt varies in quantity. If the purchase quantity is huge, such as industrial-grade large-scale purchase, the unit price may be relatively low due to scale efficiency. However, if it is a small trial in a laboratory, only a few grams or tens of grams are required, and the merchant may price it higher due to the cost of preparation, packaging, and transportation. According to past market conditions, small quantities of reagents can range from tens of yuan to hundreds of yuan per gram.
Furthermore, the purity has a great impact. Those with high purity, such as those used in pharmaceutical research and development, have strict requirements for impurities, complex preparation processes, rising costs, and high prices. Those with a purity of more than 98%, the price per gram may exceed 100 yuan. If the purity is slightly lower, it is suitable for general chemical synthesis, and the price may be relatively easy, or tens of yuan per gram.
The status of supply and demand is also key. The market demand is strong, but the supply is limited. If there is a large increase in demand for a new drug research and development, the price will rise. On the contrary, if the supply exceeds the demand, merchants may reduce the price for promotion.
The origin and brand also affect the price. Imported well-known brands often have higher prices than domestic counterparts due to strict quality control and advanced technology. Domestic production, if the production process is mature and large-scale, the price may be competitive.
Overall, the market price of 2-amino-5-bromo-3- (trifluoromethyl) pyridine is about 100 yuan per gram for small quantities and high purity; for large quantities and general purity, it is about ten yuan per gram. However, this is only a rough guess, and the actual price should be determined according to real-time market conditions.

2-Amino-5-bromo-3- (trifluoromethyl) pyridine is a crucial fine chemical in the field of organic synthesis, and is widely used in various industries such as medicine, pesticides, and materials. As far as its manufacturers are concerned, in China, many chemical companies are involved in the production of this product.
In East China, there is a fine chemical company in Shanghai. It has been deeply cultivated in the field of organic synthesis for many years, with profound technical foundation and advanced production technology. It has strict control over the production of 2-amino-5-bromo-3- (trifluoromethyl) pyridine, and its products are of high quality and are highly praised by the industry.
In South China, a chemical company in Guangdong Province also focuses on the production of this chemical. He focuses on R & D investment, works closely with universities and scientific research institutions to continuously optimize the production process and improve product quality. The 2-amino-5-bromo-3 - (trifluoromethyl) pyridine produced is not only supplied to the domestic market, but also exported overseas.
In North China, a chemical company in Jinmen is also an important manufacturer of this product. With its geographical advantages, convenient access to raw materials, and sophisticated production equipment, it has large-scale capacity and can steadily supply market needs.
In addition to Huaxia, there are also overseas manufacturers involved in the production of 2-amino-5-bromo-3- (trifluoromethyl) pyridine. Some chemical giants in Europe, America and other places, with their leading technology and strong financial strength, produce high-quality products and performance, and occupy a place in the international high-end market.
To sum up, the manufacturers of 2-amino-5-bromo-3- (trifluoromethyl) pyridine are widely distributed, and many enterprises at home and abroad participate in it. The market competition is quite fierce, but it also promotes continuous technological innovation and product quality improvement.