2-Amino-5-bromo-3-methylpyridine

2-% hydroxy-5-sulfonic acid-3-methylpyridine, although this substance is not directly mentioned in Tiangong Kaiwu, it should be involved in related applications according to the principles of ancient chemical processes and the uses of various substances.
The ancient chemical processes are mostly related to alchemy, metallurgy, pottery, dyeing and other things. In alchemy, magicians want to refine the medicine of longevity, which often involves the chemical decomposition of various gold and stone minerals. Although 2-% hydroxy-5-sulfonic acid-3-methylpyridine is not a commonly used substance in traditional alchemy, the exploration of the reaction of various substances in the process of alchemy may lay the groundwork for its discovery and application.
The matter of metallurgy is related to the extraction and refining of metals. This substance may play a role in the processing of certain metal ores, such as helping to separate impurities and adjust the reaction environment. In metallurgy, ancient craftsmen often relied on experience and repeated experiments, or accidentally found that certain combinations of substances could optimize the metallurgical effect. If 2% hydroxy-5-sulfonic acid-3-methylpyridine has special chemical properties, it may play an auxiliary role in the metallurgical process.
In the pottery process, the preparation of glaze is related to the quality and appearance of pottery. 2-% hydroxy-5-sulfonic acid-3-methylpyridine may be used for glaze improvement if it can affect the chemical and physical properties of the glaze, such as changing the melting point, color, adhesion, etc. Ancient potters often tried new formulas for exquisite pottery, and this substance may have been involved in it.
In terms of dyeing, ancient natural dyes were used to color fabrics. 2-% hydroxy-5-sulfonic acid-3-methylpyridine may be used to improve dyeing fastness and adjust color if it interacts with dyes or fabric fibers. In order to make fabrics bright and lasting, dyers will also explore various additives, and this substance may be one of their options.
In summary, although the use of 2-% hydroxy-5-sulfonic acid-3-methylpyridine is not explicitly stated in Tiangong Kaiwu, combined with the background of extensive exploration of ancient chemical processes, it may play a role in the fields of alchemy, metallurgy, ceramics, dyeing, etc., in the form of auxiliary and improved forms, which contributed to the development of ancient processes.

To prepare 2-amino-5-bromo-3-methylpyridine, there are three methods.
First, pyridine is used as a group and is converted in multiple steps. First, pyridine is halogenated and bromine atoms are introduced at the appropriate position. This step requires the selection of suitable halogenation reagents, such as bromine under specific catalytic conditions, which can make bromine atoms fall precisely at the 5th position of the pyridine ring. Subsequently, nitro is introduced into the pyridine ring through nitrification reaction, and then the nitro is reduced to an amino group to obtain the target amino group. Finally, methyl is introduced at the 3rd position through methylation reaction. Although this process is complicated, the reaction conditions at each step are relatively clear, and there are conventional methods for the separation and purification of intermediate products in each step.
Second, start from a suitable pyridine derivative. If a pyridine derivative containing part of the target substituent is selected, the target molecule can be constructed by modifying the existing group. If a methyl-containing pyridine derivative is found, a bromine atom can be introduced at a suitable position first, and then another suitable group can be converted into an amino group through clever reaction. The key to this path lies in the selection of the starting pyridine derivative, which needs to meet the needs of subsequent reactions, and can simplify the reaction steps and improve the overall yield.
Third, a cyclization strategy is adopted. Several linear organic compounds are used as raw materials, and pyridine rings are constructed by intramolecular cyclization reaction. At the same time, the target amino group, bromine atom and methyl group are introduced during or after cyclization. This method requires precise control of the reaction mechanism and conditions to ensure that the cyclization check point is accurate and the substituents are introduced in the expected manner. Its advantage is that it can start from relatively simple raw materials and construct complex pyridine structures in fewer steps, but the reaction conditions are often harsh, and the reaction equipment and operation requirements are quite high.
The above synthesis methods have advantages and disadvantages. In practical applications, when considering the availability of raw materials, the difficulty of reaction conditions, the yield and the impact on the environment, etc., the optimal route can be carefully selected to efficiently prepare 2-amino-5-bromo-3-methylpyridine.

2-% hydroxy-5-sulfonic acid-3-methylpyridine, this physical property is very complex, let me list it in detail.
This substance is either in a solid state at room temperature, and its appearance is either in the shape of a white fine powder or a crystalline state. The texture is fine and the luster is restrained.
When it comes to solubility, it can be quite compatible in water, just like fish entering water. This is because the hydroxyl and sulfonic acid groups contained in its molecular structure are hydrophilic and attract water molecules, so they can be evenly dispersed in water. In polar organic solvents, such as ethanol and acetone, it also has a certain solubility. However, in non-polar organic solvents, such as benzene and toluene, its solubility is very small, just like the incompatibility of oil and water. This is due to the great difference in the force between the molecules.
Besides stability, under normal environmental conditions, it is relatively stable and can be left in a bottle for a long time. However, if it encounters strong acids and alkalis, its structure will be easily damaged, just like a strong city meets strong soldiers, and the city walls are easily destroyed. Strong acids and alkalis will react with hydroxyl groups and sulfonic acid groups, causing the molecular structure to change and the properties to change accordingly. < Br >
In terms of thermal stability, when heated to a certain extent, it may decompose, and its decomposition temperature varies depending on specific conditions. Under high temperature, the chemical bonds in the molecule break, turn into other substances, or have gas escape, or have color changes, which are all signs of decomposition.
Its acidity is derived from sulfonic acid groups, which can ionize hydrogen ions in water, which is acidic and can neutralize with alkali substances, just like yin and yang, generating corresponding salts and water.
This 2-hydroxy-5-sulfonic acid-3-methylpyridine has unique physical properties and is useful in many fields. However, due to its special properties, it is necessary to use it with caution and follow the rules in order to make the best use of it.

Today there are 2-hydroxy-5-chloro-3-methylpyridine, what is the market price? This is a commonly used raw material in the field of fine chemicals, and its price is determined, which is related to many factors.
First, the cost of raw materials. For the preparation of this compound, the starting materials are mostly common pyridine derivatives, but the reagents required for halogenation, hydroxylation and other steps may affect the cost. If the price of the halogenating agent for the preparation of chlorine compounds rises, or the supply of special reagents used for the introduction of hydroxyl groups is in short supply and high, the cost of this compound will also increase, and the market price will increase accordingly.
Second, the difficulty of the preparation process. The synthesis of 2-hydroxy-5-chloro-3-methylpyridine requires precise control of the reaction conditions. During the halogenation reaction, the positioning and substitution number of halogen atoms need to be finely regulated, and the hydroxylation step is also prone to side reactions. If the process is complex, the equipment and technical requirements are high, and the energy consumption and labor costs in production are increased, the price is also high.
Furthermore, the market supply and demand. If the demand for this compound in the fields of medicine and pesticide research and development increases greatly, if a new type of special effect pesticide uses it as a key intermediate, the market demand will exceed the supply, and the price will rise. On the contrary, if there are many manufacturers, the supply far exceeds the demand, and the price may drop.
In addition, regional differences also affect the price. Different places have different prices due to differences in transportation costs, tax policies, and environmental protection standards. In places with developed economies and high environmental protection requirements, production costs may be high and prices are also high.
In summary, the market price of 2-hydroxy-5-chloro-3-methylpyridine is uncertain and varies with the above factors. For exact prices, consult chemical raw material suppliers or refer to recent market transaction data.

2-Amino-5-bromo-3-methylpyridine should pay attention to the following matters during storage and transportation:
First, when storing, choose a cool, dry and well-ventilated place. Due to its active chemical properties, if the temperature and humidity of the storage environment are not suitable, it is very likely to cause deterioration. This substance is prone to reaction in case of moisture and heat, so be sure to avoid humid and high temperature places. The warehouse temperature should be controlled at 15-30 ° C, and the relative humidity should be 40% - 70%.
Second, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed. The amino group, bromine atom and methyl group in the chemical structure of 2-amino-5-bromo-3-methylpyridine will chemically react with the above substances, such as oxidation, acid-base neutralization, etc., which will cause the product to fail and even cause danger.
Third, the storage area should be equipped with suitable containment materials to prevent leakage accidents. In the event of leakage, inert materials such as sand and vermiculite can be used to contain it to avoid its spread and pollution to the environment.
Fourth, during transportation, ensure that the container is well sealed to prevent it from leaking, collapsing, falling or damage. Transportation vehicles need to be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment.
Fifth, when transporting, you need to follow the specified route and do not stop in densely populated areas and residential areas. Because of its certain toxicity and danger, if an accident occurs in a crowded place, it will pose a serious threat to people's life safety and the environment.
Sixth, the handling process must be light and unloaded to prevent damage to packaging and containers. If the packaging of this substance is damaged, it will not only affect the quality of the product, but the leaked substance may also pose a safety hazard.