2-AMINO-4-(TRIFLUOROMETHYL)PYRIDINE-5-BORONIC ACID PINACOL ESTER

The chemical structure of 2-amino-4- (trifluoromethyl) pyridine-5-boronic acid pinacol ester is as follows.
The core of this compound is a pyridine ring. The pyridine ring is connected with an amino group ($- NH_ {2} $) at position 2, a trifluoromethyl group ($- CF_ {3} $) at position 4, and a boric acid pinacol ester at position 5. The boric acid pinacol ester group is a structure formed by the dehydration and condensation of two hydroxyl groups in boric acid ($B (OH) _ {3} $) and pinacol (2,3-dimethyl-2,3-butanediol). Specifically, the two hydroxyl groups ($-OH $) of boric acid and the two hydroxyl groups of pinacol remove molecular water respectively, forming a stable five-membered ring structure connected to the 5 position of the pyridine ring. The introduction of amino, trifluoromethyl and boric acid pinacol ester groups endows the compound with unique physical and chemical properties. It is often used as a key intermediate in the field of organic synthesis, especially in the reaction of constructing fluorine-containing and nitrogen-containing heterocyclic compounds.

2-Amino-4- (trifluoromethyl) pyridine-5-boronic acid pinacol ester is an important intermediate in organic synthesis and is widely used in various fields.
First, in the field of medicinal chemistry, its use is very critical. The construction of many drug molecules depends on its participation. By combining with other active groups through specific chemical reactions, compounds with specific pharmacological activities can be prepared. For example, it can be used to synthesize inhibitors targeting specific disease targets. In the development of some anti-cancer drugs, this compound can be used as a key structural unit to precisely modify drug molecules to enhance their affinity and selectivity with targets, improve drug efficacy and reduce toxic and side effects.
Second, it is also indispensable in the field of materials science. It can participate in the synthesis of functional materials, such as organic optoelectronic materials. Due to its special structure and properties, it can impart unique optoelectronic properties to materials. In the preparation of organic Light Emitting Diode (OLED) materials, this compound can optimize the charge transfer and luminous efficiency of materials, so that OLED devices exhibit better luminous properties, such as higher brightness, purer color and longer service life.
Third, in the field of organic synthetic chemistry, it is an important building block. It can use various classical organic reactions, such as Suzuki-Miyaura coupling reaction, to react with different halogenated aromatics or alkenes and other substrates to construct diverse and complex organic molecular structures. The reaction conditions are mild and highly selective, allowing the synthesis of complex organic compounds with special functions, providing a powerful tool for the development of organic synthetic chemistry and promoting the creation and research of new organic compounds.

There are many different ways to synthesize 2-amino-4- (trifluoromethyl) pyridine-5-boronic acid pinacol esters. One common approach is to start with a compound containing a pyridine structure. If a specific substituted pyridine is taken, a halogen atom is introduced into the pyridine ring first. In this step, a halogenated reagent can be used to selectively connect the halogen atom to the desired position under appropriate reaction conditions to form a halogenated pyridine derivative.
Then, the trifluoromethyl-containing group is connected by a metal-catalyzed coupling reaction. Commonly used metal catalysts, such as palladium catalysts, in the presence of bases and ligands, halogenated pyridine derivatives are coupled with trifluoromethyl-containing reagents to obtain trifluoromethyl-containing pyridine intermediates.
Finally, for the introduction of boric acid pinacol ester groups on the pyridine ring, boronizing reagents, such as double pinacol borate, can be used to react under a metal catalytic system. The metal catalytic system or palladium, nickel and other metal catalysts with corresponding ligands, at a suitable temperature and reaction time, promote the interaction of the intermediate with the boronizing reagent, and finally obtain 2-amino-4- (trifluoromethyl) pyridine-5-boronic acid pinacol ester. < Br >
There is also another method. The basic skeleton containing trifluoromethyl and pyridine is first constructed, and then the amino and boric acid pinacol ester groups are gradually introduced through functional group transformation. This approach requires fine planning of the reaction sequence and conditions, and proper consideration of the interaction between each step of the reaction to ensure the smooth synthesis and obtain the target product.

2-Amino-4- (trifluoromethyl) pyridine-5-boronic acid pinacol ester, the price of this product in the market is difficult to determine. Its price often changes for many reasons, just like the market situation, unpredictable.
Its price depends on the state of supply and demand. If there are many people in the market, and the demand exceeds the supply, the price will often rise. Like the pharmaceutical industry, when developing new drugs, the demand for this product increases sharply, and its price may skyrocket at that time. On the contrary, if the supply exceeds the demand, the stock is in the market, and the price will decline.
Furthermore, the manufacturing cost is also a major factor. The price of raw materials, if the required raw materials are scarce or difficult to harvest, resulting in high raw material prices, the price of finished products will also rise. The complexity of the preparation process also has an impact. If the process is complicated, many steps and fine equipment are required, and human and material resources are costly, the price is not cheap.
The quality is also related to the price. High purity and high quality, the price must be higher than the ordinary product. In areas with strict quality requirements such as fine chemicals, it is better to ask for high-quality goods at high prices.
The difference in regions also makes the price different. The convenience of transportation and the congestion of logistics all make the cost different, resulting in poor prices. < Br >
The price of this product on the market may range from tens of yuan to hundreds of yuan per gram. However, this is only a rough figure. The actual price must be consulted with the chemical raw material supplier and the current market conditions in detail before a more accurate price can be obtained.

2-Amino-4- (trifluoromethyl) pyridine-5-boronic acid pinacol ester, which is a commonly used reagent in organic synthesis. When storing and transporting, many key matters should be paid attention to.
First words storage, because of its active nature, it is highly susceptible to moisture hydrolysis, so it should be stored in a dry place, preferably in a sealed container to prevent moisture intrusion. If stored in a humid environment, the substance will react with water, causing structural changes, reducing purity and activity, and ultimately affecting the experimental effect. And to avoid high temperature, excessive temperature can easily trigger decomposition reactions and lead to deterioration. Generally speaking, it should be stored in a cool place, and the temperature should not exceed 25 ° C.
When it comes to transportation, because it may have certain chemical hazards, the transportation process must strictly follow the relevant regulations. Appropriate packaging materials should be selected to ensure that there will be no leakage due to vibration and collision during transportation. And the transportation environment should also be kept dry and cool to prevent direct sunlight and high temperature invasion. Transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies such as leakage, they can quickly and properly dispose of it to avoid causing greater harm.
In short, the storage and transportation of 2-amino-4- (trifluoromethyl) pyridine-5-boronic acid pinacol ester must be treated with caution, and environmental conditions and operating specifications must be strictly controlled to ensure its quality and safety.