2-Amino-4-Methyl-5-Bromopyridine

2-% hydroxyl-4-methyl-5-methoxypyridine. Although this substance is not directly recorded in Tiangong Kaiwu, its use can be deduced from the perspective of ancient pharmacy and technology.
In the field of pharmacy, pyridine compounds containing hydroxyl groups, methyl groups and methoxy groups often have biological activities. Hydroxyl groups can enhance the hydrophilicity of compounds, which is conducive to their transportation and metabolism in organisms. They can also participate in the formation of hydrogen bonds, affect the interaction between compounds and biological macromolecules, or have antibacterial and anti-inflammatory effects. Methyl groups can change the molecular spatial structure and electron cloud distribution, affect the lipid solubility and biological activity of compounds, or enhance the affinity of drugs to specific targets. The presence of methoxy groups can adjust the polarity and stability of molecules, and in drug design, it can improve the absorption, distribution, metabolism and excretion characteristics of drugs. Therefore, 2-hydroxy-4-methyl-5-methoxy pyridine can be used as a medicinal ingredient, which can be extracted, purified and prepared for the prevention and treatment of diseases.
In the field of technology, pyridine derivatives are often used as intermediates in organic synthesis. The specific functional groups of 2-hydroxy-4-methyl-5-methoxy pyridine can participate in many chemical reactions, such as esterification and etherification of hydroxy groups, and nucleophilic substitution of methoxy groups. With these reactions, more complex organic compounds can be synthesized for the production of dyes, fragrances, pesticides, etc. For example, in dye synthesis, by modifying its structure, chromophore groups are introduced to synthesize dyes with specific colors and properties; in perfume synthesis, perfume molecules with unique aroma structures are constructed using their reaction properties.

To prepare 2-amino-4-methyl-5-methoxypyrimidine, there are various methods.
First, the corresponding pyrimidine derivative can be obtained by a series of reactions of amination, methylation and methoxylation. First, find a suitable pyrimidine parent, introduce the amino group with an amination reagent, such as ammonia or its derivatives react with the pyrimidine parent under suitable conditions, or convert the suitable substituent into an amino group by means of diazotization-reduction. Then, select methylating reagents, such as iodomethane, dimethyl sulfate, etc., and react with the amino-containing pyrimidine intermediate in an alkaline environment to introduce methyl groups. Finally, the methoxylation reagent, such as sodium methoxide, is used to connect the methoxyl group to the pyrimidine ring to obtain the target product.
Second, the strategy of constructing the pyrimidine ring can be used. Nitrogen-containing and carbon-containing raw materials, such as ethyl cyanoacetate, methylamine, formaldehyde, etc., are directly constructed by condensation and cyclization under appropriate catalyst and reaction conditions, and amino, methyl, methoxy and other substituents are introduced at the same time. For example, ethyl cyanoacetate is first condensed with methylamine to obtain a nitrogen-containing carbon chain intermediate, and then cyclized with formaldehyde and other reagents under acid or base catalysis. During the process, the reaction conditions can be controlled to achieve the purpose of introducing each substituent at a suitable position.
Third, it can also be started from halogenated pyrimidine derivatives. First prepare halogenated pyrimidine, use halogen atoms as active check points, react with amination reagents, methylation reagents, and methoxylation reagents in sequence, and gradually introduce the required groups. This process requires attention to the selectivity and condition control of each step of the reaction, such as reaction temperature, solvent, type and dosage of base, etc., to prevent side reactions and ensure the formation of the target product. And after each step of the reaction, appropriate separation and purification methods, such as extraction, distillation, recrystallization, etc., are required to obtain high-purity products.

The physical properties of 2-% hydroxy-4-methyl-5-methoxypyridine are as follows:
This substance is mostly crystalline solid at room temperature, and the appearance is usually white or almost white powder. The texture is fine and uniform. Under the illumination of light, you can occasionally see a subtle luster flickering, just like fine ice crystals, which are pure and clear.
Smell it, its smell is slight and specific, not pungent and intolerable. However, under the fine taste, it is still different from common odorless substances. This smell is unique. Although it is not strong, it can be recognized by people's sense of smell.
When it comes to solubility, it shows a certain affinity in organic solvents. Such as in ethanol, it can be moderately dissolved, and with the increase of temperature, the dissolution rate accelerates and the solubility increases. In water, the solubility is poor, and only a very small amount can be dispersed in it. Most of them are suspended in tiny particles, like tenaciously sticking to their own independent state in the world of water.
Its melting point is also an important physical property. After determination, it is about a certain temperature range. Under this temperature, it survives in a stable solid state, with a solid structure and stable intermolecular forces. When the temperature gradually rises to near the melting point, the molecules are energized to intensify the vibration, and the structure begins to loosen, slowly changing from solid to liquid, just like the melting of ice and snow, transforming from a regular state into a smart flow. < Br >
Its density is slightly higher than that of common organic solvents, and when placed in a specific container, it can be seen that it sits firmly at the bottom, highlighting the thickness of its substance. And because of its physical properties, in many fields such as organic synthesis, drug research and development, it can be separated, purified, and the reaction conditions can be precisely controlled according to its solubility, melting point, etc., providing an important material basis and theoretical basis for related scientific research and industrial production.

When storing 2-% hydroxy-4-methyl-5-methoxypyrimidine, pay attention to the following key points:
The first dry environment. This substance is highly susceptible to moisture. Once it is damp, it may cause changes in properties and even cause deterioration. Therefore, it must be stored in a dry place, away from water sources, sinks and other places where moisture is easy to accumulate, and an appropriate amount of desiccant can be placed in the storage container to keep the environment dry.
The second is temperature control. It should be stored in a cool and low temperature place, usually 2-8 ° C. Too high temperature or cause it to decompose, too low temperature or cause crystallization of substances, which affects its chemical activity and quality. Do not place it in direct sunlight or near high-temperature equipment.
Furthermore, it is also crucial to isolate the air. Some groups in this compound may react with oxygen, carbon dioxide and other components in the air, thereby changing its chemical structure. Therefore, the storage container should be well sealed and sealed in time after use to prevent air intrusion.
In addition, avoid contact with incompatible substances. Due to its unique chemical properties, it may come into contact with some acids, bases, oxidants, reducing agents and other substances, or cause violent reactions. When storing, it should be placed separately from such substances to prevent inadvertent contact.
At the same time, the label identification must be clear and accurate. Key information such as the name of the substance, purity, production date, shelf life, etc. should be clearly marked on the container to facilitate management and use, and to prevent misuse and misuse.
The storage site also needs to have good ventilation conditions. To prevent the accumulation of volatile gases of substances and reduce latent risks.
Finally, strictly follow relevant regulations and standards. Act in accordance with chemical storage management practices to ensure legal compliance of storage operations and ensure personnel and environmental safety.

Today there are 2-hydroxy-4-methyl-5-methoxypyridine, what is the market price? This is related to the medicinal substance, the price is high or low, often depends on various factors.
First, look at the purity. If its purity is extremely high, impurities are rare, and the preparation process is complicated, it requires exquisite methods and expensive materials, and the price will be very high. Just like the finely crafted beautiful jade, the price of flawless jade is more than ordinary. For example, if the purity is above 99%, it is the best choice for scientific research experiments, and its price can be several times higher than that of 95% purity.
Second, it depends on the scale of production. If a merchant mass-produces, due to the efficiency of scale, the unit cost may be reduced, and the price will also become more affordable. It is like a workshop making utensils, and if the quantity is large, the labor cost will be diluted. On the contrary, a small amount of special production, the price will be high.
Third, it is related to market supply and demand. If there are many people who want it, but there are few people who supply it, the price will rise. In case of a new drug research and development boom, the demand for this product will surge, and the supply will outstrip the demand. The price will rise like a rising tide.
Fourth, the raw materials and production methods also have an impact. If the required raw materials are scarce and difficult to find, or the production method is time-consuming and labor-intensive, the cost will be
According to the current market conditions, the price fluctuates between tens of yuan and hundreds of yuan per gram. However, the market is volatile, and the price changes at any time. To know the exact price, you should consult the chemical raw material supplier and reagent supplier, and check their latest quotations and trading conditions carefully.