2-Amino-4-hydroxypyridine

2-Amino-4-hydroxypyridine has a wide range of uses. In the field of medicine, it is an important pharmaceutical intermediate. With its delicate chemical synthesis path, it can be converted into a variety of specific drugs, which can be used to combat many stubborn diseases such as cardiovascular diseases and nervous system diseases. Due to the unique chemical structure of this compound, it can precisely combine with specific biomacromolecules in organisms, thereby regulating the physiological and biochemical processes in organisms and achieving the purpose of treating diseases.
In the field of materials science, it also plays a key role. It can be used as a basic raw material for the construction of special functional materials. Using it as a starting material, through a series of complex reactions and treatments, polymer materials with excellent properties can be prepared. These materials either have excellent electrical conductivity or good optical properties, and have extraordinary application prospects in many high-end fields such as electronic devices and optical instruments, which can greatly improve the performance and function of related devices.
Furthermore, in the field of organic synthetic chemistry, 2-amino-4-hydroxypyridine is an extremely important synthetic block. Because of its rich activity check points in its structure, it can participate in a variety of chemical reactions, such as nucleophilic substitution reactions, cyclization reactions, etc. By ingeniously designing reaction routes, chemists can use them to construct complex and diverse organic compounds, injecting continuous vitality into the development of organic synthetic chemistry, and promoting the creation and exploration of new organic compounds.

2-Amino-4-hydroxypyridine is also an organic compound. The synthesis method of 2-amino-4-hydroxypyridine has been used throughout the ages. All kinds of techniques have their own advantages.
One method is to use pyridine as a group, nitrate pyridine, and then reduce it, so that the nitro group can be transferred to the amino group, and then use an appropriate reagent to hydroxylate a specific position under suitable conditions. This is the classic way. First, the mixed acid of concentrated nitric acid and concentrated sulfuric acid is slowly reacted with pyridine at low temperature to obtain nitropyridine. This step requires careful observation of the temperature and reaction process to prevent side reactions. Then iron powder, hydrochloric acid, etc. are used as reducing agents to make nitro groups into amino groups. Then select suitable hydroxylating reagents, such as alkali metal hydroxides, etc., under a specific solvent, temperature and time, to promote the introduction of hydroxyl groups at specific positions.
There are also those who use nitrogen-containing heterocyclic compounds as starting materials by rearrangement and substitution. For example, with a specific nitrogen-containing heterocyclic ring, the molecular structure is rearranged to obtain an intermediate, and then halogenated with a halogenated reagent, and then reacted with a nucleophilic reagent to replace the halogen atom with a hydroxyl group, and finally obtain 2-amino-4-hydroxypyridine. In this process, the conditions of the rearrangement reaction, such as temperature and catalyst selection, are crucial. Halogenation and nucleophilic substitution steps also require fine regulation of the reaction conditions to increase the purity and yield of the product.
Another method of biosynthesis has emerged. Using the catalytic properties of microorganisms or enzymes, specific substrates are used as raw materials and synthesized under mild conditions. Biosynthesis is green and efficient, but the control of the reaction system requires strict control. It is necessary to precisely regulate the growth environment of microorganisms or the active conditions of enzymes, such as temperature, pH, substrate concentration, etc., in order to make the synthesis proceed smoothly.
All synthesis methods have their own advantages and disadvantages. According to actual needs, many factors such as raw material cost, reaction conditions, product purity and yield should be weighed to choose the best way to obtain this 2-amino-4-hydroxypyridine.

2-Amino-4-hydroxypyridine is one of the organic compounds. Its physical properties are quite specific, let me tell them one by one.
Looking at its appearance, it usually takes the form of white to light yellow crystalline powder. This morphology is also common in many chemical substances, but its internal characteristics are unique.
When it comes to the melting point, 2-amino-4-hydroxypyridine is about 210-214 ° C. The melting point is the critical temperature at which a substance changes from solid to liquid. This specific melting point range provides an important basis for the identification and identification of this compound. Just as humans have a unique logo, the melting point of compounds is also one of their characteristics.
In terms of solubility, it has a certain solubility in water. Water is the source of all things, and many substances dissolve differently in it. 2-Amino-4-hydroxypyridine can dissolve in water, indicating that there is a specific interaction between it and water molecules. In organic solvents, such as ethanol, acetone, etc., it also has a certain solubility. This solubility characteristic has an important impact on its separation, purification and participation in chemical reactions in chemical experiments and industrial applications.
In addition, 2-amino-4-hydroxypyridine has a certain stability. However, under specific conditions, such as high temperature, strong acid or strong alkali environment, its structure and properties will also change. The characteristics of this stability are like human character, which remains stable under normal conditions, and will also react when the external environment changes suddenly.
From this perspective, the physical properties of 2-amino-4-hydroxypyridine, from appearance, melting point to solubility and stability, are its unique "chemical business card", which plays an indispensable role in the research and application of chemistry.

The chemical properties of 2-amino-4-hydroxypyridine are particularly important. This compound is amphoteric because it contains amino and hydroxyl groups. The amino group is basic and can form salts with acids; the hydroxyl group can also exhibit acidic properties under appropriate conditions and can react with bases.
In terms of its reactivity, the amino group can participate in a variety of nucleophilic reactions. For example, when it encounters the acyl halide, the nitrogen atom of the amino group will launch a nucleophilic attack on the carbonyl carbon of the acyl halide, resulting in the formation of amide derivatives. This reaction is often used in organic synthesis to construct complex molecules containing amide bonds.
In addition, the hydroxyl group also has unique reactivity. Substitution reactions can occur, such as with halogenated hydrocarbons under basic conditions, the oxygen atom of the hydroxyl group nucleophilically attacks the carbon atom of the halogenated hydrocarbons, and the halogen atom leaves to form the corresponding ether compound.
In addition, 2-amino-4-hydroxypyridine has certain stability due to its conjugated system, and has a specific response to external factors such as light and heat. In solution, its acidity and alkalinity can affect the existence form and reactivity of molecules, which in turn has a significant effect on the process of related chemical reactions and product formation. Its chemical properties are rich and diverse, and it has important application value in many fields such as organic synthesis and medicinal chemistry. It provides key structural units and reaction check points for the synthesis of novel compounds and the development of drugs.

The price range of 2-amino-4-hydroxypyridine in the market is difficult to determine. Due to the complex market conditions, the price is often influenced by various factors.
First, the purity of the product has a great impact on the price. If the purity is extremely high, almost perfect, and reaches the high standard required for scientific research, the price will be high; on the contrary, if the purity is slightly lower, for general industrial use, the price will be slightly lower.
Second, the supply and supply and demand trends are also key. If the supply of this product is abundant in the market, but the demand is not strong, the price may stabilize or even drop; however, if the supply is scarce and the demand is strong, such as in the pharmaceutical industry, the price will rise.
Third, the cost of production also affects the price. The price of raw materials, the simplicity of the preparation process, and the amount of energy consumption will all be reflected in the final selling price. If the raw materials are rare and expensive, the process is complex and time-consuming, and the price is high.
Looking at past examples, the price per gram of 2-amino-4-hydroxypyridine with higher purity may be between tens and hundreds of yuan; while the price per kilogram may be around hundreds of yuan for those with slightly lower purity and for industrial batch demand. However, this is only a rough estimate. The actual price should be subject to the current market conditions. It is necessary to consult the supplier in detail to obtain accurate figures.