2-amino-4-ethoxypyridine

2-% hydroxy-4-ethoxybenzaldehyde, which has important uses in many fields.
In the field of medicine, it is a key pharmaceutical intermediate. It can be synthesized through a series of chemical synthesis steps to construct drug molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, it can be used as a starting material to introduce key benzene rings and specific substituents, which can be modified and transformed to generate drugs that inhibit or kill specific bacteria, and help in pharmaceutical research and development and disease treatment.
In the fragrance industry, 2-% hydroxy-4-ethoxybenzaldehyde plays an important role. Due to its unique chemical structure and special aroma, it can be used to prepare a variety of fragrances. It can add unique freshness and sweetness to floral fragrances, making the fragrance layer richer. It is widely used in fragrance formulations of perfumes, air fresheners, detergents and other products to improve the aroma quality and attractiveness of products.
In the field of organic synthesis, it is an important reaction substrate. With the chemical activity of hydroxyl and ethoxy groups on the benzene ring and aldehyde groups, it can participate in many classic organic reactions, such as condensation reactions, oxidation and reduction reactions. Chemists use this to construct complex organic molecular structures, expand the types and functions of organic compounds, and promote the development and innovation of organic synthesis chemistry.

To prepare 2-amino-4-ethoxyaniline, there are many methods, and the following are common methods:
First, p-nitrochlorobenzene is used as the starting material, and it is first heated with sodium ethanol, and the nucleophilic substitution reaction is carried out to obtain p-nitrophenethyl ether. After iron filings and hydrochloric acid are used as the reducing agent, the nitro group is returned to the amino group, and the final product is obtained. The raw material of this route is easy to obtain, but the method of iron filings reduction, the by-product iron mud is many, the subsequent treatment is complicated, and it is polluted to the environment.
Second, p-nitrophenol is used as the starting material, and bromoethane is reacted in an alkaline environment to form p-nitrophenethyl ether. Then the method of catalytic hydrogenation is used to reduce the nitro group to an amino group under the action of suitable catalysts such as palladium carbon. The method of catalytic hydrogenation has high product purity and less three wastes, but it requires high equipment, needs to be operated under a certain pressure and temperature, and the catalyst is expensive.
Third, 2-amino-4-chloroaniline is used as raw material and reacts with sodium ethanol, and the chlorine atom is replaced by ethoxy group to obtain 2-amino-4-ethoxy aniline. This method is simple, but the raw material of 2-amino-4-chloroaniline is not easy to obtain, and the reaction conditions also need to be precisely controlled.
Fourth, through the Ullmann reaction, p-nitrohalobenzene is co-heated with ethanol, copper powder and alkali to form p-nitrophenyl ether, and then the nitro group is reduced to obtain the product. The Ullmann reaction requires high temperature, and the catalytic efficiency of copper powder may be restricted by many factors, and the reaction selectivity also needs to be considered in detail.
In short, each method has its advantages and disadvantages. In actual preparation, when considering factors such as raw material availability, cost, environmental protection and product requirements, carefully weigh and choose the best method.

2-% hydroxyl-4-ethoxybenzaldehyde is an organic compound. It has many physical properties.
Looking at its appearance, it is often white to light yellow crystalline powder with fine texture. This form is easy to store and use, and also reflects the orderly arrangement of its molecules.
When it comes to the melting point, it is about 41-44 ° C. The low melting point indicates that the intermolecular force is relatively weak. Under moderate heating, the molecules are easy to obtain enough energy to get rid of the lattice binding and transform from solid to liquid state. This characteristic can be achieved by controlling the temperature during specific chemical reactions or material processing. In terms of boiling point, it is roughly around 294 ° C. A higher boiling point means that a large amount of energy needs to be supplied in order to make the molecules overcome the attractive force between each other and change from liquid to gaseous state, which reflects that the intermolecular force is easily broken at a higher temperature. This property is of great significance for its separation, purification and participation in high temperature reactions.
In terms of solubility, it is slightly soluble in water, but soluble in organic solvents such as ethanol and ether. Because water is a polar solvent, and the molecular polarity of the compound is relatively weak, according to the principle of "similar compatibility", it is difficult to dissolve in water; the polarity of the organic solvent is similar to that of the compound, so it can be mutually soluble. This property makes it possible to dissolve, disperse and participate in reactions with the help of organic solvents in the fields of organic synthesis and drug preparation.
In addition, 2-hydroxy-4-ethoxybenzaldehyde also has a certain odor, which is difficult to describe accurately, but can be used as one of the identification characteristics. In practical applications and analysis, olfactory discrimination may assist in the preliminary determination of its existence.

In today's market, the price of 2-hydroxy-4-ethoxybenzaldehyde varies depending on the quality and quantity, and the supply and demand. If it is an ordinary commercial product and the quantity is not huge, the price per kilogram is about hundreds of dollars. If its quality is purer, it is suitable for areas with strict quality requirements such as medicine and fine chemicals, and the price may be doubled or even higher.
If the quantity is quite large, block trade, and the price may be slightly reduced because of it, but it also depends on the supply and demand of the market. When there is an oversupply, merchants will reduce their prices to attract buyers in order to sell their goods quickly; if the supply is less than the demand, the price may rise. < Br >
And this change in price is also related to the source of production. If the origin is wide, the yield is abundant, and the transportation is easy, the price will stabilize or drop slightly; if the origin is narrow, the production is difficult, the transportation is difficult, and the price is often high and difficult to drop. The situation of the city is ever-changing, and the price is also unstable. Therefore, if you want to know the exact price, you need to carefully observe the market situation and consult the merchants before you can get it.

2-% hydroxy-4-ethoxyacetophenone is also an organic compound. Its storage conditions are related to the stability of its properties and the effectiveness of its use, which cannot be ignored.
This substance should be placed in a cool, dry and well-ventilated place. If it is cool, it should be protected from heat. Heat can cause molecular movement, or cause it to decompose or deteriorate. The temperature should not exceed 30 degrees Celsius. If it is hot in summer, there should be cooling measures, such as installing an air-conditioned temperature-controlled room, or using ice packs to help reduce its peripheral temperature.
Dry environment to prevent moisture. The moisture is easy to combine with the substance, or lead to the reaction of hydrolysis. In rainy seasons or humid places, a desiccant can be placed next to it, such as silica gel desiccant, to absorb surrounding water vapor and keep it dry.
Well ventilated, it can dissipate possible harmful gases and avoid their accumulation. If it is in a storage room, when a fan is set up, turn it on when it is turned on, change the air in the room, and keep the air fresh.
And this material should be stored with oxidants, acids, and bases. Oxidants have strong oxidizing properties, and when they are encountered, they may cause violent oxidation reactions, generate heat, generate combustion, or even explode; acids and bases are active, mixed with them, or cause chemical reactions, which damage their structure and lose their original properties.
When handling, care must also be taken. Pack and unload lightly to avoid collisions and falls. Collisions and falls make the container vulnerable, and the material may escape, which not only pollutes the environment, but also poses a safety hazard.
In this way, according to this storage condition, the quality of 2-hydroxy-4-ethoxyacetophenone can be maintained for a long time, so as to prepare for the required use.