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What are the main uses of 2-amino-4-cyanopyridine?
2-Amino-4-cyanopyridine is an organic compound. It has a wide range of uses and is useful in various fields.
In the field of medicinal chemistry, this compound is often an important traditional Chinese medicine and can be used as a raw material for the synthesis of various drugs. Due to its unique structure, it can participate in the construction of molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, 2-amino-4-cyanopyridine can contribute its amino and cyano groups. After chemical modification, the resulting drug has excellent antibacterial properties to deal with various bacterial infections.
In the field of materials science, it can also be used as a starting material for the preparation of special functional materials. Through specific chemical reactions, it is introduced into the structure of polymer materials and imparts new properties to the materials. It can enhance the stability of materials, or make them have special optical and electrical properties, and have applications in electronic devices, optical materials, etc.
Furthermore, in the field of organic synthetic chemistry, 2-amino-4-cyanopyridine is a key synthetic building block. Because of its high reactivity of amino and cyano groups, it can react with many reagents such as nucleophilic substitution and addition, providing an effective way to construct complex organic molecular structures. Chemists can use this to construct various carbon-nitrogen bonds and other chemical bonds, expand the structural diversity of organic compounds, and lay the foundation for the creation of new substances.
To sum up, 2 - amino - 4 - cyanopyridine is an indispensable compound in many fields such as medicine, materials and organic synthesis, and has significant effect on promoting the development of various fields.
What are the physical properties of 2-amino-4-cyanopyridine?
2-Amino-4-cyanopyridine is an organic compound. It has unique physical properties, which are detailed as follows.
When it comes to appearance, 2-amino-4-cyanopyridine is often in the form of a white-like to light yellow crystalline powder. This form is quite stable in ordinary environments and is easy to identify and handle.
As for the melting point, it is usually in a specific temperature range. It has been determined by many experiments to be between [specific melting point range]. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This property is of great significance when identifying and purifying the compound.
In terms of solubility, 2-amino-4-cyanopyridine exhibits a certain solubility in some organic solvents. For example, in alcoholic solvents such as methanol and ethanol, it can be moderately dissolved. However, in water, its solubility is relatively limited. This difference in solubility is due to the difference between the molecular structure of the compound and the interaction between solvent molecules. The molecular structure of organic solvents may be more compatible with 2-amino-4-cyanopyridine, and it can be dissolved by intermolecular forces such as hydrogen bonds and van der Waals forces. Although the polarity of water is strong, the interaction with the compound cannot reach the required degree of effective dissolution, so the solubility is poor.
Furthermore, the stability of 2-amino-4-cyanopyridine is also an important physical property. Under normal temperature and humidity conditions, its chemical structure can be stable for a long time without the influence of special chemical reagents or external strong factors. In case of extreme conditions such as high temperature, strong acid, and strong base, chemical reactions may be triggered, resulting in structural changes, which in turn affect its physical properties and chemical activities.
In addition, the density of the compound is also a physical characterization. Although the exact density value needs to be determined by rigorous experiments, its approximate range is helpful for estimating the relationship between mass and volume in practical applications, providing an important reference for operation during preparation, storage, and transportation.
It can be seen from the above that the physical properties of 2-amino-4-cyanopyridine are diverse and interrelated, and play an indispensable role in many fields such as organic synthesis and drug development. Only through in-depth understanding of its physical properties can this compound be used more scientifically and effectively.
2-amino-4-cyanopyridine chemical synthesis methods
The chemical synthesis method of 2-amino-4-cyanopyridine has been investigated by many predecessors, and is described in detail as follows.
First, the method of using pyridine as the starting material. First, the pyridine is nitrified to obtain the nitropyridine derivative. With a suitable reducing agent, such as iron and hydrochloric acid system, the nitro group is reduced to an amino group to obtain the aminopyridine derivative. Then, through cyanation, the aminopyridine derivative is reacted with the cyanide reagent, such as potassium cyanide or sodium cyanide, under specific conditions, and the cyano group can be introduced to obtain the final 2-amino-4-cyanopyridine. This approach is a bit complicated, but the raw material pyridine is easy to obtain, and the cost is controllable.
Second, starting from nitrogen-containing heterocyclic compounds. For example, some specific pyrimidine compounds are used as the starting materials, through a series of reactions such as ring opening, rearrangement and introduction of cyano and amino groups. This process requires precise control of the reaction conditions, but the special structure of heterocyclic compounds can be used to simplify part of the reaction process and improve the selectivity of the target product.
Third, halogenated pyridine is used as the raw material. First select a suitable halogenated pyridine, and carry out an amination reaction with an amination reagent, such as ammonia or an amine compound, in the presence of a catalyst, and replace the halogen atom with an amino group. Subsequently, 2-amino-4-cyanopyridine can be synthesized by the cyanidation step and the cyanyl group is introduced. This method has relatively mild reaction conditions and high reactivity of halogenated pyridine, which is conducive to the reaction and is also a common synthesis strategy.
All these methods have their own advantages and disadvantages. When synthesizing, it is necessary to consider the cost of raw materials, reaction conditions, product purity and many other factors according to actual needs, and carefully select them to achieve the best synthesis effect.
What is the price range of 2-amino-4-cyanopyridine in the market?
The price range of 2-amino-4-cyanopyridine in the market is difficult to say exactly. Due to the changeable market conditions, the price is often influenced by many factors.
On the source side of raw materials, if the raw materials are easy to obtain and the output is abundant, the cost may be reduced, and the selling price may also be reduced; on the contrary, if the raw materials are scarce and difficult to collect, the cost will rise, and the selling price will increase accordingly.
Furthermore, the production process is also the key. An exquisite and efficient process can improve output efficiency, reduce energy consumption, and make the product price more competitive; while a complicated and inefficient method will increase the cost and the price will remain high.
Market supply and demand conditions have a particular impact on prices. With strong demand and limited supply, prices tend to rise; when supply exceeds demand, merchants may reduce prices in order to promote sales.
In addition, factors such as regional differences and quality grades will make prices different. Generally speaking, in the ordinary chemical raw material market, the price may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, this is only a rough estimate. The actual price should be consulted with each supplier in detail, subject to real-time market conditions.
What are 2-amino-4-cyanopyridine storage conditions?
2-Amino-4-cyanopyridine is one of the chemical substances. Its storage conditions are crucial and related to the quality and safety of this substance.
At the beginning of storage, find a cool and dry place. Cover 2-amino-4-cyanopyridine with moisture and heat. If it is placed in a warm and humid place, it is afraid of chemical changes and deterioration. A cool place can slow down its molecular activity and maintain its chemical stability; a dry place can avoid its fusion with water vapor and avoid adverse reactions such as hydrolysis.
Furthermore, the storage place needs to be well ventilated. This substance may evaporate a little gas. If the ventilation is not smooth and the gas accumulates, it will damage itself on the one hand, and there may be a risk of safety on the other, such as explosion, poisoning, etc. Good ventilation can make the gas dissipate and maintain the safety of the storage environment.
And keep away from fire and heat sources. 2-Amino-4-cyanopyridine encounters open flames, hot topics, or causes combustion, or even explosions, endangering the surroundings. Therefore, in the storage place, fireworks are strictly prohibited, and various heat sources are properly placed to keep a safe distance from them.
At the same time, it should be stored separately from oxidants, acids, bases and other substances. Because of its active chemical properties, coexisting with the above, it is easy to trigger chemical reactions, or cause fires, explosions, or generate harmful substances. Isolated storage can avoid interactions and ensure safety.
Storage containers should not be ignored. Use a sealed device to prevent it from evaporating and getting damp. And the material of the container should be compatible with 2-amino-4-cyanopyridine, and it should not chemically react with it, so as not to damage the container and the substance itself.
During storage, it should also be checked regularly. Check whether its packaging is in good condition and whether there is any leakage; check whether its properties change, such as color, smell, etc. If there is any abnormality, dispose of it quickly to avoid the expansion of harm. All of these are essential for the storage of 2-amino-4-cyanopyridine and must be handled with caution.