2-Amino-4-chloropyridine

2-Amino-4-chloropyridine is also an organic compound. It has a wide range of uses and is used in medicine, pesticides, materials and other fields.
In the field of medicine, it is a key intermediate. Due to its special structure, it can be converted into biologically active compounds through many chemical reactions, and then used to create new drugs. For example, based on this, it can synthesize drug molecules with antibacterial, antiviral, anti-tumor and other effects. Pharmaceutical developers often use its unique nitrogen heterocyclic structure and substituent properties to build a new drug skeleton and explore high-efficiency and low-toxicity therapeutic drugs.
In terms of pesticides, 2-amino-4-chloropyridine also plays an important role. It can be used in the preparation of pesticides, fungicides and other pesticide products. Due to its chemical properties, it can react with other compounds to generate pesticide ingredients with specific biological activities, which is of great benefit to the control of crop diseases and pests. It can precisely act on specific targets of pests or pathogens, effectively inhibit their growth and reproduction, ensure the healthy growth of crops, and improve crop yield and quality.
In the field of materials, it can participate in the synthesis of some functional materials. For example, in the field of photoelectric materials, by combining with other conjugated structural units, the electronic structure and optical properties of the material can be adjusted, and materials with specific photoelectric properties can be prepared for use in organic Light Emitting Diodes, solar cells and other devices, which contributes to the development of materials science. Due to its important use in many fields, it has attracted much attention in the chemical synthesis industry and has become the focus of research and application for many researchers and industry professionals.

2-Amino-4-chloropyridine is also an organic compound. It has unique physical properties and is widely used in various fields of chemistry.
Looking at its properties, it is mostly white to light yellow crystalline powder at room temperature. This form is easy to store and use, and can be well dispersed in many reaction systems, which is conducive to the progress of the reaction.
When it comes to the melting point, it is between 116-119 ° C. The melting point is an inherent property of the substance. This specific melting point range can help identify the compound and is of great significance in separation, purification and other operations. When the temperature reaches this range, 2-amino-4-chloropyridine gradually melts from solid to liquid. According to this characteristic, its purity can be determined by melting point measurement. If the purity is high, the melting point range is narrow and approaches the theoretical value.
In terms of solubility, it is slightly soluble in water, but soluble in organic solvents such as methanol, ethanol, and acetone. This solubility characteristic is related to the molecular structure. The existence of amino groups and pyridine rings in the molecule makes it have a certain polarity, so it has a certain solubility in polar organic solvents. Although water is a polar solvent, its structure is quite different from that of 2-amino-4-chloropyridine, resulting in its limited solubility in water. This solubility allows it to be selected in different reaction media. In organic synthesis, a suitable solvent can be selected according to the reaction requirements to promote the smooth occurrence of the reaction.
In addition, the stability of 2-amino-4-chloropyridine is also an important physical property. Under normal conditions, its properties are relatively stable, and its structure may change under extreme conditions such as strong acid, strong base or high temperature. Such unfavorable factors need to be avoided during storage to ensure that its chemical structure and properties remain unchanged and ensure that it has the same effect in subsequent applications.

2-Amino-4-chloropyridine is also an organic compound. The synthesis method is described in the past literature, roughly as follows.
One method is to use 4-chloropyridine-2-carboxylic acid as the starting material. First, the acid is co-heated with dichlorosulfoxide to transform the acid into an acyl chloride. In this process, dichlorosulfoxide is used as a chlorination reagent, and the reaction is intense. It needs to be controlled moderately to prevent it from getting out of control. After the acyl chloride is formed, cool down and slowly add concentrated ammonia water. Ammonia reacts with acyl chloride to obtain 4-chloropyridine-2-formamide. In this step, it is necessary to pay attention to the amount of ammonia and the rate of drip, so as to avoid side reactions. The resulting formamide is then treated with sodium hypochlorite alkaline solution. This is a Hoffman rearrangement reaction, where the amide group is converted to an amino group, and 2-amino-4-chloropyridine is obtained. In this process, the concentration of sodium hypochlorite, the reaction temperature and time need to be precisely regulated to achieve the best yield.
Another method uses 2-chloro-4-nitropyridine as the starting material. It is heated with iron powder and hydrochloric acid to carry out a reduction reaction. Iron powder is used as a reducing agent here, and hydrochloric acid provides an acidic environment. Nitro is gradually reduced to amino groups to obtain 2-amino-4-chloropyridine. However, in this reaction system, the amount of iron powder, the concentration of hydrochloric acid, and the reaction temperature and time have a great impact on the purity and yield of the product. After the reaction, the remaining iron powder and acidic waste liquid need to be properly disposed of.
Others use 2-hydroxy-4-chloropyridine as a raw material. First, it is co-heated with phosphorus oxychloride, and the hydroxyl group is replaced by chlorine to obtain 2,4-dichloropyridine. This reaction needs to be carried out under the protection of inert gas, and phosphorus oxychloride is highly toxic and corrosive, so the operation needs to be cautious. 2,4-Dichloropyridine reacts with ammonia at high temperature and pressure and under the action of a catalyst, and the monochlorine atom is replaced by an amino group to obtain 2-amino-4-chloropyridine. In this reaction, the choice of catalyst, temperature and pressure control are related to the success or failure of the reaction.
All these methods have advantages and disadvantages. It is necessary to choose carefully according to actual needs, such as the availability of raw materials, the level of cost, and the requirements of product purity. Only then can 2-amino-4-chloropyridine be effectively synthesized.

In today's world, it is not easy to know the price range of 2-amino-4-chloropyridine in the market. The market conditions are fickle, and the price fluctuates for many reasons.
In the past, the price of things that were easy to change in the market always depended on supply and demand. If there are many people who want this thing, but there are few suppliers, the price will increase; on the contrary, if the supply exceeds the demand, the price will be reduced.
In addition, the origin, quality, and method of making this thing also have a great impact on the price. The origin is different, the convenience of obtaining materials and the amount of freight can make the price different. Those with high quality often have higher prices than ordinary products. The method of preparation is simple and the cost is high or low, which also affects the price.
Looking at past transactions, the price may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, this is only a rough figure, and it cannot be determined. In recent years, the chemical industry has undergone repeated changes, new technologies have emerged, and the price of raw materials has also risen and fallen from time to time, making the price of 2-amino-4-chloropyridine elusive.
To get an accurate price, when consulting chemical material merchants, trade companies, or visiting chemical trading platforms, you can know the current price range with real-time information. It is impossible to judge today's market just by the price of the past year.

2-Amino-4-chloropyridine is an organic compound. Its storage conditions are crucial and related to the stability and quality of this substance.
When it is stored, the first environment is dry. If this substance encounters water vapor or hydrolysis, its chemical structure will be damaged and its performance will be different. Therefore, it should be placed in a dry place, away from water sources and moisture-filled places.
Control of times and temperature. It should be stored in a cool place to avoid high temperature and hot topics. Under high temperature, 2-amino-4-chloropyridine may react chemically, cause molecular structure turbulence, or cause decomposition, polymerization, etc., which will damage its original characteristics. Generally speaking, the temperature should not exceed 30 ° C.
Furthermore, it is necessary to prevent it from contacting with oxidants, acids and other substances. When the two meet, it is easy to cause violent reactions, or risk explosion or combustion, endangering safety. It must be isolated and placed in different places.
In addition, the storage place is well ventilated. Good ventilation can dissipate harmful gases that may escape, reduce its concentration in the air, reduce safety risks, and help maintain the stability of the environment and maintain the quality of this substance.
As for storage containers, use corrosion-resistant materials, such as glass, specific plastics, etc. Such materials do not chemically react with them, ensuring their integrity and preventing leakage.
In short, the storage of 2-amino-4-chloropyridine must adhere to the principles of drying, cooling, isolation, ventilation, and selection of suitable containers to ensure its quality and safety for subsequent use.