2-AMINO-4-CHLORO-5-NITROPYRIDINE

2-Amino-4-chloro-5-nitropyridine, which is an important compound in the field of organic synthesis, has a wide range of uses.
One is that it plays a significant role in the synthesis of medicine. In the preparation of many drugs, 2-amino-4-chloro-5-nitropyridine is often used as the key intermediate. Due to its specific chemical structure, it can participate in a series of chemical reactions, and after ingenious construction and modification, it can be converted into drug molecules with specific pharmacological activities. For example, some new drugs targeting specific disease targets have been developed, and with the help of their structural characteristics, they can precisely target and exert therapeutic effects.
Second, in the field of pesticides, it is also indispensable. As an important raw material for synthetic pesticides, a variety of highly efficient pesticide varieties can be derived. By reacting with other chemicals, compounds with good insecticidal, bactericidal or weeding properties can be generated. These pesticides can effectively protect crops from pests and diseases, improve crop yield and quality, and escort agricultural production.
Third, in the field of materials science, 2-amino-4-chloro-5-nitropyridine also shows unique value. It can be used to synthesize materials with special properties, such as some functional polymer materials. Through its participation in polymerization reactions, materials are endowed with specific electrical, optical or mechanical properties, which meet the needs of different fields for special materials, and have broad application prospects in electronic devices, optical instruments, etc.
In short, 2-amino-4-chloro-5-nitropyridine plays a key role in many fields such as medicine, pesticides and materials science due to its unique chemical structure, and is of great significance for promoting the development of related industries.

2-Amino-4-chloro-5-nitropyridine, this is an organic compound. Looking at its physical properties, it is mostly in the shape of a solid state at room temperature, but the specific state may vary depending on the purity and crystal form.
Its melting point is related to the intermolecular force and lattice energy. The exact value often needs to be determined experimentally. However, due to the existence of polar groups in the molecule, such as amino groups and nitro groups, the intermolecular force is enhanced, so the melting point is relatively high.
In terms of solubility, because it contains polar groups, it may have a certain solubility in polar solvents. For example, in water, although polar groups can form hydrogen bonds with water molecules, their solubility is limited due to the presence of pyridine rings and chlorine atoms. In common organic solvents, such as methanol, ethanol, dichloromethane, etc., according to the principle of similar miscibility, or have good solubility. Methanol and ethanol have similar polarity to compounds and can interact with them to improve dissolution; although dichloromethane has weak polarity, it can interact with pyridine rings to a certain extent, which is also helpful for dissolution.
Above the appearance, pure or white to light yellow crystalline powder. If it contains impurities, the color may change. The depth of color is often related to the type and content of impurities. < Br >
In terms of odor, it usually has the special smell of certain organic compounds. However, the intensity and characteristics of the specific odor are difficult to describe accurately. It is necessary to smell and perceive it yourself, and such substances may be irritating to a certain extent. When smelling, caution should be used.
The determination of density requires precise experimental methods. In theory, due to the molecular structure containing atoms with relatively large atomic masses such as chlorine, nitrogen, and oxygen, the density may be higher than that of common hydrocarbon compounds.
The physical properties of this compound are of great significance to its synthesis, separation, purification, and application in many fields. Experimenters must carefully consider and make good use of it.

The chemical synthesis of 2-amino-4-chloro-5-nitropyridine is described in detail.
The first one can be started from 4-chloropyridine. First, 4-chloropyridine is nitrified by a mixed acid system of concentrated nitric acid and concentrated sulfuric acid. In this mixed acid system, nitric acid is the active species provider of nitrification, and sulfuric acid helps nitric acid to form nitroyl positive ions to facilitate the nitrification reaction. The reaction conditions should be controlled at moderate low temperature to prevent excessive nitrification or damage to the pyridine ring. In this way, 4-chloro-5-nitropyridine can be obtained.
Second, 4-chloro-5-nitropyridine is treated with a suitable amination reagent. Common amination reagents such as ammonia in combination with a catalyst, or sodium azide through subsequent conversion. If ammonia is used, it can be reacted in an autoclave at an appropriate temperature. In this process, ammonia provides an amino group and replaces the chlorine atom to obtain 2-amino-4-chloro-5-nitropyridine.
Or, it can be started from pyridine and first chlorinated. In the presence of a catalyst, chlorine atoms are introduced at the 4 position of the pyridine ring. After the above, the target product can also be reached through nitration and amination steps.
During the synthesis process, the conditions of each step are controlled to be critical. Temperature, reaction time, and reagent ratio all affect the yield and selectivity of the reaction. And after each step of the reaction, it needs to be separated and purified, such as extraction, distillation, recrystallization, etc., to remove impurities and obtain a pure product. In this way, 2-amino-4-chloro-5-nitropyridine is obtained.

2-Amino-4-chloro-5-nitropyridine is an important chemical substance. When storing and transporting, there are many matters to be paid attention to.
Bear the brunt, the storage place must be dry and well ventilated. This substance is susceptible to moisture, causing damage to its quality and even chemical reactions. Therefore, the warehouse should be kept dry, the humidity should not be too high, and there should be good ventilation equipment to disperse harmful gases that may accumulate.
Furthermore, temperature is also a key factor. It should be stored in a cool place to avoid high temperature. High temperature can easily make the substance unstable, or cause reactions such as decomposition. In general, the storage temperature should be controlled within a specific range, and it should not be exposed to direct sunlight or high temperature environment.
During transportation, the packaging must be firm and reliable. The substance may be dangerous, so the packaging material should be able to effectively protect and prevent leakage. The container used should be chemically resistant to ensure that there is no risk of damage during transportation.
In addition, it is also necessary to pay attention to its isolation from other substances. 2-Amino-4-chloro-5-nitropyridine cannot be mixed with oxidizing substances, reducing substances, etc. Due to its active chemical properties, contact with certain substances may cause violent reactions, endangering transportation safety.
And in the storage and transportation places, corresponding emergency treatment equipment and protective equipment should be equipped. In the event of an accident such as leakage, relevant personnel can take prompt measures to reduce the harm. In short, all aspects of storage and transportation should be treated with caution to ensure the safety of this chemical substance.

There is a question today, what is the market price range of 2-amino-4-chloro-5-nitropyridine. This chemical has a wide range of uses in the chemical industry, but its price fluctuates very frequently, which is difficult to say for sure.
Looking at the state of the market in the past, its price is affected by many factors. The first one to bear the brunt is the price of raw materials. To prepare this pyridine compound, the abundance and cost of the raw materials used are directly related to its cost, which in turn affects the selling price. If the raw materials are scarce and expensive, the price of the product will be high; conversely, if the raw materials are abundant and cheap, the price of the product is expected to drop.
Furthermore, the production process is also key. Sophisticated craftsmanship can increase productivity and reduce energy consumption, so that costs can be controlled and prices may become more affordable; while crude methods have low productivity and high energy consumption, and the price of products will rise.
Market supply and demand are also the main reasons for price changes. If demand is strong and supply is insufficient, prices will rise; if demand is low and supply is excessive, prices may fall.
In addition, factors such as the current situation, policies and regulations can also be affected. In case of trade disputes, tariffs will increase, transportation will be inconvenient, and prices may fluctuate; stricter environmental protection policies and limited production can also affect supply and prices.
In summary, the price of 2-amino-4-chloro-5-nitropyridine can range from a few hundred yuan per kilogram to several thousand yuan. To know the exact price, consult chemical product suppliers or check the current market conditions.