2-amino-4-bromopyridine

2-Amino-4-bromopyridine is an organic compound with unique physical properties. It is mostly solid at room temperature. Due to the interaction of hydrogen bonds and van der Waals forces between molecules, the molecules are arranged in an orderly manner to form a solid-state structure.
The compound has a certain melting point, but the exact value varies depending on the purity and test conditions. It is roughly within a specific temperature range. When melting, it needs to absorb energy to overcome the intermolecular force.
Its solubility is also an important physical property. The solubility in water is limited, and the interaction between the cover and water molecules is not strong enough because of its relatively weak molecular polarity. However, in some polar organic solvents, such as ethanol and dichloromethane, the solubility is better, because the molecules can form appropriate interactions with these organic solvent molecules, such as hydrogen bonds or van der Waals forces, to help them disperse in the solvent.
2 - amino - 4 - bromopyridine has a certain density, and the density is related to its molecular weight and the way of molecular accumulation, reflecting the mass of the substance per unit volume.
In addition, the compound may have a specific odor, which is caused by molecular volatilization and stimulates olfactory receptors. Although the odor description of your mileage may vary, it can provide clues to identify the substance.
Overall, the physical properties of 2-amino-4-bromopyridine are restricted by its molecular structure and intermolecular interactions, and understanding these properties is critical for its applications in organic synthesis, drug discovery, and other fields.

2-Amino-4-bromopyridine is a nitrogen-containing heterocyclic organic compound. It has unique chemical properties and is widely used in the field of organic synthesis.
The physical properties of this compound are mostly solid at room temperature, due to intermolecular forces. Its solubility is also an important property. It may have a certain solubility in organic solvents such as ethanol and dichloromethane. Due to the principle of similar miscibility, its organic structure is compatible with organic solvents.
In terms of chemical properties, amino and bromine atoms give it active reactivity. Amino groups are nucleophilic groups and can participate in many nucleophilic substitution reactions. For example, when encountering halogenated hydrocarbons, the nitrogen atom of the amino group can attack the carbon atom of the halogenated hydrocarbons with its lone pair electrons, and the halogen atom leaves to form a new carbon-nitrogen bond, which is an important step in the construction of complex organic molecules.
Bromine atoms also play a key role in compounds. It can participate in electrophilic substitution reactions. Due to the electron-absorbing properties of bromine atoms, the electron cloud density of the pyridine ring is reduced, making specific positions on the ring more vulnerable to electrophilic reagents. Moreover, bromine atoms can be connected to other organic fragments through metal-catalyzed coupling reactions, such as Suzuki reactions and Stille reactions, which greatly expand the synthesis path of compounds and lay the foundation for the creation of new organic materials and drug molecules.
2 - amino - 4 - bromopyridine is rich in chemical properties and plays an indispensable role in the stage of organic synthetic chemistry. With its unique reactivity, it helps researchers to construct a variety of organic compounds and has broad application prospects in materials science, drug development and other fields.

2-Amino-4-bromopyridine is also an important intermediate in organic synthesis. Its common synthesis methods are as follows:
First, 4-bromopyridine-2-carboxylic acid is used as the starting material. First, 4-bromopyridine-2-carboxylic acid is co-heated with dichlorosulfoxide to convert the carboxyl group into an acid chloride. This step requires mild temperature control to prevent side reactions. The obtained acid chloride reacts with ammonia water to obtain 4-bromopyridine-2-formamide. Finally, formamide is degraded by Hoffmann, and under the action of alkaline and bromine, the amide group is converted into an amino group to obtain 2-amino-4-bromopyridine.
Second, use 2-aminopyridine as raw material. In a suitable solvent, such as glacial acetic acid or dichloromethane, add a brominating reagent, such as liquid bromine or N-bromosuccinimide (NBS). During the reaction, pay attention to the reaction temperature and the amount of brominating reagent. Because the amino group is an ortho-para-site group, the control conditions can make the main substitution of bromine in the fourth position, so as to obtain the target product.
Third, start from 4-bromopyridine. 4-Bromopyridine first interacts with a suitable protective group to protect the nitrogen atom from the interference of the nitrogen atom in the reaction. After that, under the action of amination reagents, such as sodium azide and subsequent reduction steps (such as lithium aluminum hydride reduction), the amino group is introduced, and then the protective group is removed to obtain 2-amino-4-bromopyridine. In this way, the selection of protective groups and the removal conditions are both key and need to be carefully regulated.

2-Amino-4-bromopyridine is an organic compound with nitrogen, bromine and other atoms. It has a unique structure and has extraordinary applications in the fields of medicine, pesticides, and material science.
In the field of medicine, it is a key intermediate. Due to the properties of pyridine rings and amino and bromine atoms, it can be chemically modified to produce specific bioactive compounds. If the substituents are adjusted, the affinity and selectivity of molecules and biological targets can be changed. Studies have shown that drugs containing 2-amino-4-bromopyridine have inhibitory effects on specific cancer cells, can hinder the proliferation and spread of cancer cells, or are the cornerstone of the development of new anti-cancer drugs. In addition, in the research and development of drugs for neurological diseases, it can regulate the activity of neurotransmitter receptors to achieve therapeutic purposes, such as potential regulatory effects on targets related to Alzheimer's disease and Parkinson's disease.
In the field of pesticides, 2-amino-4-bromopyridine also plays an important role. The introduction of bromine atoms enhances its fat solubility and stability, making it easier for pesticides containing this structure to penetrate the waxy layer on the body surface of pests and improve the insecticidal effect. For example, some new insecticides, using 2-amino-4-bromopyridine as raw materials, have efficient killing effects on lepidoptera and homoptera pests, and have low environmental residues, which is in line with the development needs of modern green pesticides. In terms of fungicides, it can be used to complex with metal ions to produce antibacterial active compounds and protect crops from fungi.
In the field of materials science, 2-amino-4-bromopyridine can be used to synthesize functional materials. Because its amino and bromine atoms can participate in the polymerization reaction, polymers with special properties can be prepared. If polymerized with conjugated monomers, materials with photoelectric properties can be obtained, which can be used in organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices. In OLEDs, such materials can be used as light-emitting layers or transport layers to improve the luminous efficiency and stability of devices; in solar cells, they can enhance light absorption and charge transfer, and improve the photoelectric conversion efficiency of batteries.

The market price of 2-amino-4-bromopyridine is difficult to determine. The price of the cover often changes for a variety of reasons, and the market situation is changeable, and the price also fluctuates accordingly.
Looking at the price of chemical industry in the past, the supply and demand of raw materials are the key. If the raw materials required for the synthesis of 2-amino-4-bromopyridine are widely sourced and oversupplied, the price may stabilize or even drop. On the contrary, if the raw materials are scarce and the supply is difficult, the price will rise.
Furthermore, the preparation method is also related to the cost and price. If there is a convenient and efficient method, the material will be saved and the cost will be reduced, and the market price may be close to the people. If the preparation is complicated, time-consuming and expensive, the price will be difficult to lower.
Market demand also affects its price. If many industries have high demand for 2-amino-4-bromopyridine, such as medicine, pesticides and other industries rely on it as an important intermediate, the demand is greater than the supply, and the price will rise. If demand is low and supply exceeds demand, the price will fall.
In addition, changes in the world also have an impact. For example, the issuance of a government order is related to the regulations of chemical production, or the cost may increase or decrease, which will cause the price to move. Or a sudden natural and man-made disaster will disrupt the supply of raw materials and the order of production, and the price will also change. < Br >
If you want to know the accurate market price, you should carefully check the chemical market reports, consult the merchants specializing in this product, or refer to the relevant transaction records to obtain a more accurate price. However, the price changes at any time, and you need to pay attention in real time to know the situation.