2-Amino-4-(benzyloxy)pyridine

2-Amino-4- (benzyloxy) pyridine is a valuable compound in organic synthesis. It has a wide range of uses, first in the field of medicinal chemistry. In this field, it is often used as a key intermediate to create a variety of drug molecules. Due to its unique structure, it can be modified by various chemical reactions, thereby imparting specific biological activities to the synthesized drugs, such as antibacterial, anti-inflammatory, and anti-tumor equivalent properties.
In the field of materials science, this compound has also emerged. By introducing it into polymer materials by appropriate chemical means, it can effectively improve the properties of materials, such as enhancing the stability, conductivity or optical properties of materials. This is of great benefit when preparing new functional materials.
Furthermore, in the basic research of organic synthesis chemistry, 2-amino-4- (benzyloxy) pyridine is often used as a model compound. By exploring the various reaction mechanisms it participates in, such as nucleophilic substitution, electrophilic substitution, and metal catalysis, researchers can provide important theoretical basis and practical experience for the development of organic synthesis methodologies, and help to develop more efficient and green organic synthesis strategies.
In summary, 2-amino-4- (benzyloxy) pyridine plays an indispensable role in drug development, material creation, and basic research in organic synthesis. It is of great significance to promote scientific progress and technological innovation in related fields.

To prepare 2-amino-4- (benzyloxy) pyridine, there are three methods. The first method is to start with 4-hydroxypyridine, first with benzyl halide, such as benzyl bromide or benzyl chloride, stored in a base, such as potassium carbonate, in a suitable solvent, such as acetonitrile or N, N-dimethylformamide, nucleophilic substitution reaction is carried out to obtain 4- (benzyloxy) pyridine. Next, with a suitable amination reagent, such as sodium azide, the azide is formed first, and then reduced, such as hydrogenation with lithium aluminum hydride or palladium carbon, the target can be obtained. < Br >
Second, 2-nitro-4- (benzyloxy) pyridine is used as raw material. This compound can be prepared by benzylation of 4-hydroxypyridine first and then nitration. 2-nitro-4- (benzyloxy) pyridine is reduced to amino groups by reducing agents such as iron and hydrochloric acid, or catalytic hydrogenation, palladium carbon is used as a catalyst, and hydrogen is used as a hydrogen source to reduce nitro groups to amino groups, then 2-amino-4- (benzyloxy) pyridine is obtained.
Third, using pyridine derivatives as substrates, benzyloxy and amino groups are constructed through multi-step reactions. For example, with 4-halogenated pyridine, a halogen atom such as chlorine or bromine, first with benzyl alcohol in the presence of a base and appropriate ligands, such as cesium carbonate and tri-tert-butylphosphine, nucleophilic substitution is introduced into the benzyloxy group. Then, through a suitable amination strategy, such as the Ullmann reaction, using a copper salt as a catalyst, an amine source such as ammonia or an amine compound, at high temperature and with the assistance of ligands, the amino group is introduced to synthesize 2-amino-4- (benzyloxy) pyridine.

2-Amino-4- (benzyloxy) pyridine is an important compound in organic chemistry. Its physical properties are unique and of great research value.
Looking at its properties, it usually shows a white to light yellow crystalline powder state. This state is easy to store and handle, and in many chemical reactions, the powder form is more conducive to full contact between substances and accelerates the reaction process.
When it comes to the melting point, it is about 100-105 ° C. As an important physical property of a substance, the melting point can help identify its purity. If the melting point of the sample is consistent with the standard value and the melting range is narrow, it can be proved that its purity is very high; on the contrary, if the melting point deviation is large and the melting range is wide, it may contain impurities.
In terms of solubility, the compound is slightly soluble in water, but easily soluble in common organic solvents, such as ethanol, dichloromethane, acetone, etc. This solubility characteristic is of great significance in organic synthesis. When constructing the reaction system, an appropriate solvent can be selected according to its solubility to ensure that the reactants are fully dissolved and achieve a good reaction effect. In the stage of product separation and purification, it can also take advantage of its solubility differences and choose suitable methods, such as extraction, to obtain high-purity products.
Its density is about 1.21 g/cm ³. Density data are indispensable in chemical production and experimental operations. When formulating solutions and determining the proportion of reactants, density can help to accurately calculate the amount of substances, thereby ensuring the smooth progress of experiments and production processes.
The physical properties of 2-amino-4- (benzyloxy) pyridine, from their properties, melting point, solubility to density, are related to each other and affect their application in organic synthesis, drug development and other fields. These properties provide important basis for researchers to design experiments, optimize reaction conditions, and perform product separation and identification, and are of great significance for promoting the development of related fields.

2-Amino-4- (benzyloxy) pyridine is a key intermediate in organic synthesis and is of great importance in the field of medicinal chemistry. Its chemical properties are unique, containing amino and benzyloxy groups, which give the compound a variety of reactivity.
Let's talk about the amino group first. As a nucleophilic group, the amino group is active and easy to react with electrophilic reagents. In case of acyl halide, the nitrogen atom on the amino group will nucleophilically attack the carbonyl carbon in the acyl halide and form an amide through nucleophilic substitution. This reaction is often used to introduce specific functional groups in the construction of drug molecular structures, laying the foundation for the optimization of drug activity. In addition, when reacting with halogenated hydrocarbons, amino groups can participate in nucleophilic substitution, form new carbon-nitrogen bonds, expand the molecular skeleton, and provide the possibility for the synthesis of complex drugs.
Looking at the benzyloxy group, the benzene ring in the benzyloxy group is connected to the oxygen atom. Due to the conjugation of the benzene ring, the benzyloxy group is relatively stable. However, under certain conditions, the benzyloxy group can be broken. For example, under the condition of catalytic hydrogenation, the carbon-oxygen bond in the benzyloxy group can be hydrogenated under the action of the catalyst to generate a hydroxyl group, which is of great significance in the late modification of drug synthesis. It can precisely introduce the hydroxyl group, change the polarity, solubility and interaction mode of the drug molecule with the target,
At the same time, the pyridine ring of the compound also has special properties. The nitrogen atom of the pyridine ring has a certain alkalinity and can react with acids to form salts. This property can be used to adjust the physical and chemical properties of the compound, such as improving its solubility in water, which is conducive to the development of pharmaceutical formulations. In addition, the pyridine ring can participate in a variety of electrophilic substitution reactions. By rationally designing the reaction conditions and reagents, different functional groups can be introduced at specific positions of the pyridine ring, which further enriches the diversity of molecular structures and meets the needs of drug development for structural diversification. In summary, 2-amino-4- (benzyloxy) pyridine plays an indispensable role in drug synthesis chemistry due to these unique chemical properties.

I have not yet confirmed the price of 2 - Amino - 4 - (benzyloxy) pyridine on the market. However, if you want to estimate its price, you should consider various factors.
First look at the difficulty of its preparation. If its preparation requires a sophisticated method, the materials used are rare, the process is long and the purification is difficult, the price will be high. On the contrary, if the preparation method is easy, the materials used are common, and the price may be slightly lower.
Check the demand for the second time. In pharmaceutical research and development, if it is an intermediary for the synthesis of key drugs, and the drug is in high demand, the price of this compound should not be low. Or if it is an important raw material in the field of materials science, its demand will also increase.
Furthermore, market competition is also a major factor. If there are many producers of this compound, the supply will exceed the demand, and the price may drop; if there are few suppliers, the demand will exceed the supply, and the price will rise.
In addition, differences in regions, logistics costs, etc., can also make the price different. Generally speaking, without more information, it is difficult to determine the exact price. Or due to the above factors, the price fluctuates in a wide range, from a low price of a few yuan per gram to a high price of several hundred yuan per gram, it is possible. It is necessary to carefully investigate market dynamics, production processes and other details to obtain a close price range.