2-Amino-4,6-dichloropyridine

2-Amino-4,6-dichloropyridine is widely used in the chemical and pharmaceutical fields.
In the process of chemical synthesis, this is an important intermediate. Many organic compounds can be derived from it through specific chemical reactions. Due to the unique activity of amino and chlorine atoms in the molecular structure, it can participate in various nucleophilic substitution, condensation and other reactions. By nucleophilic substitution, chlorine atoms can be replaced by other functional groups, thereby constructing more complex and diverse organic molecules, laying the foundation for the synthesis of special materials, dyes and other chemical products.
In the creation of medicine, its role is also crucial. Due to its specific chemical structure, it has potential biological activity. The study found that with this as the starting material, through a series of chemical modifications and optimizations, new drug molecules with antibacterial, antiviral or anti-tumor activities can be prepared. The drug molecules built on it can precisely act on specific targets in organisms, or interfere with the metabolic process of pathogens, or affect the proliferation signaling pathway of tumor cells, and then exert therapeutic effects.
Furthermore, in the field of pesticide research and development, 2-amino-4,6-dichloropyridine has also emerged. With this as the core structure, high-efficiency pesticides, fungicides and other pesticide products can be created. Due to their unique chemical structure and biological activity, these pesticides can effectively kill crop pests and pathogens, ensure the healthy growth of crops, and improve the yield and quality of crops. They are indispensable in modern agricultural production.

2-Amino-4,6-dichloropyridine is an important compound in organic chemistry. Its physical properties are particularly critical and have a great impact on its application in many fields.
When it comes to appearance, 2-amino-4,6-dichloropyridine is often in the state of white to pale yellow crystalline powder. Such appearance characteristics are an important basis for identification in actual operation and identification. Its color and morphology can help chemists preliminarily determine the purity and characteristics of substances.
Melting point is also a key physical property. The melting point of 2-amino-4,6-dichloropyridine is about 148-152 ° C. The exact value of the melting point is of great significance in the purification and identification of compounds. By accurately measuring the melting point, it can be clear whether the substance is pure. If the melting point deviates from the standard range, it may suggest that impurities are mixed in.
In terms of solubility, this compound is slightly soluble in water. However, in organic solvents, such as ethanol, acetone, and dichloromethane, it has good solubility. Such solubility characteristics determine the selection and application of organic solvents in chemical reactions and separation and purification processes. In organic synthesis reactions, selecting a suitable organic solvent can promote the dissolution of the reactants and make the reaction easier to proceed.
In addition, 2-amino-4,6-dichloropyridine has certain stability. However, under certain conditions, such as high temperature, strong acid or strong alkali environment, its structure may change. Understanding this stability characteristic, when storing and using the compound, appropriate measures can be taken to avoid deterioration due to environmental factors.
In summary, the physical properties of 2-amino-4,6-dichloropyridine, from appearance, melting point, solubility to stability, play a crucial role in its application in chemical research, industrial production and related fields.

The synthesis method of 2-amino-4,6-dichloropyridine has been known in ancient times, and this is a detailed description for you.
First, 4,6-dichloropyridine-2-carboxylic acid is used as raw material, which is a commonly used method. First, 4,6-dichloropyridine-2-carboxylic acid is heated with sulfinyl chloride, so that it undergoes an acylation reaction to obtain 4,6-dichloropyridine-2-formyl chloride. This reaction needs to be controlled by temperature. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow. Then, 4,6-dichloropyridine-2-formyl chloride is reacted with ammonia to obtain 4,6-dichloropyridine-2-formamide. In this step, the amount of ammonia and the reaction time are both critical. After treatment with 4,6-dichloropyridine-2-formamide with an oxidant such as sodium hypochlorite or sodium bromate, 2-amino-4,6-dichloropyridine can be obtained through Hoffman rearrangement reaction. During operation, the dropwise rate of the oxidant and the pH of the reaction system need to be carefully adjusted.
Second, take 2-hydroxy-4,6-dichloropyridine as the starting material. First, 2-hydroxy-4,6-dichloropyridine is reacted with dichlorosulfoxide, and the hydroxyl group is replaced by a chlorine atom to obtain 2,4,6-trichloropyridine. This reaction needs to be carried out in an anhydrous environment to prevent side reactions. Then 2,4,6-trichloropyridine is reacted with liquid ammonia, and the reaction conditions are controlled so that one of the chlorine atoms is replaced by an amino group to obtain 2-amino-4,6-dichloropyridine. During this process, the pressure of liquid ammonia and the reaction temperature have a great influence on the purity and yield of the product.
Third, use 2-methoxy-4,6-dichloropyridine as raw material. First, 2-methoxy-4,6-dichloropyridine is treated with ammonia water, and the methoxy group is replaced by the amino group to form 2-amino-4,6-dichloropyridine. The conditions of this reaction are mild or not, which is related to the quality of the product, and the choice of solvent is also important. Different solvents or reaction rates and yields vary.
All synthesis methods have their own advantages and disadvantages. In practical application, the choice should be made carefully according to factors such as the availability of raw materials, cost, and purity requirements of the product.

It is difficult to determine the price range of 2-amino-4,6-dichloropyridine in the market. The price of 2-amino-4,6-dichloropyridine often varies due to various factors, such as the cost of raw materials, the production process, the supply and demand of the market, and even regional differences and the batch of transactions.
Looking at past market conditions, the price of this chemical may fluctuate greatly at different times and between different merchants. If the raw materials are abundant and the production process is advanced, the cost can be controlled, and the price may stabilize or even decline; conversely, if the raw materials are scarce and the production is in trouble, the price may rise.
And the price varies depending on the transaction batch. Bulk purchasers may get better prices due to economies of scale; small purchasers, per unit price or higher. And different regions, due to logistics costs and market competition, their selling prices may vary.
Although it is difficult to give an exact price range, for details, you can consult the chemical product trading platform, chemical suppliers, and refer to relevant industry reports and market surveys to obtain more accurate and timely price information.

2-Amino-4,6-dichloropyridine is a crucial chemical raw material in the field of organic synthesis and is widely used in pesticides, medicine and other industries. The following are some common manufacturers of synthesizing this substance:
Shandong Yanhe Chemical Co., Ltd., which specializes in Chemical Products Research & Development and Production, has accumulated deep experience in the synthesis process of 2-amino-4,6-dichloropyridine. Its advanced technology and strict quality control system ensure high product quality and have a good reputation in the market.
Wuhan Yuancheng Co., Ltd. has a long-standing reputation in the chemical industry. When producing 2-amino-4,6-dichloropyridine, it focuses on technological innovation and optimization of processes. The company can meet the diverse needs of different customers for product quantity and quality with its own strong R & D and capacity.
Changzhou Jiana Chemical Co., Ltd. is also an important manufacturer of 2-amino-4,6-dichloropyridine. The company has been committed to improving product quality. During the synthesis process, it strictly follows relevant standards and specifications. The products produced have high purity and excellent performance, and are recognized in domestic and foreign markets.
However, the production enterprises of chemical products may change over time, and the market competition is fierce, and the development trend of each manufacturer varies. If you need to purchase 2-amino-4,6-dichloropyridine, it is recommended to comprehensively inspect the manufacturer's reputation, product quality, price and after-sales service, so as to select the supplier that best meets your own needs.