2-Amino-3-methoxy-5-bromopyridine

2-Amino-3-methoxy-5-bromopyridine is also an organic compound. It has a wide range of uses and is a key synthetic intermediate in the field of medicinal chemistry. Using it as a raw material, through various chemical reactions, a variety of biologically active drug molecules can be prepared. For example, when developing antibacterial drugs, with its unique chemical structure, it can combine with specific targets in bacteria to interfere with the normal physiological metabolism of bacteria, thus achieving antibacterial effect.
In the field of pesticide chemistry, 2-amino-3-methoxy-5-bromopyridine also has important uses. It can be used as a starting material for the synthesis of high-efficiency and low-toxicity pesticides. It can be chemically modified and transformed to generate pesticide products that have significant inhibitory or killing effects on crop pests, and are less harmful to the environment, which is in line with the current needs of green agriculture development.
Furthermore, in the field of materials science, it can also be seen. Participating in the synthesis of some organic materials can endow materials with special electrical, optical or thermal properties, providing novel approaches and options for the development and preparation of new functional materials. From this perspective, 2-amino-3-methoxy-5-bromopyridine has shown important application value in many fields such as medicine, pesticides and materials due to its unique chemical structure, providing an indispensable chemical basis for the development of various fields.

To prepare 2-amino-3-methoxy-5-bromopyridine, the general number method. First, start with 3-methoxy-pyridine, brominate first, then amide. In a suitable solvent, such as dichloromethane, 3-methoxy-pyridine is blended with bromine and a suitable catalyst such as iron powder, and the temperature control makes the bromination reaction smooth to obtain 3-methoxy-5-bromopyridine. Then it is reacted with liquid ammonia and a catalyst such as copper salt in an autoclave at high temperature to obtain the target product.
Second, start from 2-amino-3-hydroxypyridine. 2-Amino-3-methoxypyridine is obtained by methoxylation with dimethyl sulfate and other methylating reagents in an alkaline environment, such as potassium carbonate, in a suitable solvent such as acetonitrile. Subsequently, N-bromosuccinimide (NBS) is used as a bromine source, in an inert solvent such as carbon tetrachloride, in light or with an initiator, to achieve 5-position bromination to obtain 2-amino-3-methoxy-5-bromopyridine.
Third, the rearrangement reaction of pyridine derivatives is used. Select suitable substituted pyridine derivatives, and through specific rearrangement conditions, such as strong alkalinity or specific metal reagents, first form the rearrangement intermediate, and then gradually introduce amino, methoxy and bromine atoms through subsequent conversion to synthesize the target compound. Each method has its own advantages and disadvantages, and the actual synthesis needs to be carefully selected according to factors such as raw material availability, cost and reaction conditions.

2-Amino-3-methoxy-5-bromopyridine is one of the organic compounds. Its physical properties are crucial and related to many chemical applications.
Looking at its appearance, it is usually a white-like to light yellow crystalline powder. This feature is easy to identify. In laboratory or industrial production, the preliminary identification of substances by their appearance helps chemists quickly recognize.
When it comes to melting point, it is about 155-159 ° C. Melting point is an inherent property of a substance, which is of great significance for the determination of the purity of a compound. Those with high purity have a narrow melting point range and are close to the theoretical value; those with impurity have a reduced melting point and a wider range. Therefore, the purity of 2-amino-3-methoxy-5-bromopyridine can be measured, which lays the foundation for its quality control.
In terms of solubility, it has certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), but poor solubility in water. This property affects its medium selection in chemical reactions. The reaction is easier to proceed in organic solvents because it can fully contact the reactants and improve the reaction rate and efficiency.
Furthermore, the stability of the compound needs to be considered. At room temperature and pressure, if properly stored, it can be maintained relatively stable. In case of high temperature, open flame or strong oxidizing agent, it may be risky. High temperatures may cause it to decompose, change its chemical structure and properties; strong oxidizing agents may come into contact with it, or cause severe oxidation reactions. Therefore, when storing and using, it is necessary to follow safety regulations to ensure the safety of personnel and the environment.
In short, the physical properties of 2-amino-3-methoxy-5-bromopyridine, such as appearance, melting point, solubility and stability, are of guiding significance for its research, production and application in the field of chemistry. Chemists need to be familiar with these properties in order to use this compound rationally and carry out efficient and safe chemical work.

2-Amino-3-methoxy-5-bromopyridine, this is an organic compound. It is basic because its amino group accepts protons. In nucleophilic substitution reactions, bromine atoms are highly active and easily replaced by nucleophilic reagents. Due to the electronegativity of bromine and the electronic effect of the pyridine ring, the C-Br bond is polarized, which is conducive to the attack of nucleophilic reagents. Methoxy is the power supply group, which can enhance the electron cloud density of the pyridine ring, affecting the reaction activity and selectivity.
The compound has considerable stability, but under specific conditions, such as strong acids, strong bases or high temperatures, the structure may change. Its solubility varies from solvent to solvent. It has better solubility in polar organic solvents such as methanol, ethanol, and dimethyl sulfoxide, and poor solubility in non-polar solvents such as n-hexane and benzene.
In the field of organic synthesis, 2-amino-3-methoxy-5-bromopyridine is widely used. It can be used as a key intermediate to synthesize drugs, pesticides, dyes, etc. When synthesizing specific biologically active drug molecules, amino, methoxy, and bromine atoms can all be used as reaction check points, and complex molecular structures can be constructed through a series of reactions to obtain desired pharmacological properties.

2-Amino-3-methoxy-5-bromopyridine is on the market, and its price range is difficult to determine. The price of this product often varies due to various factors. First, the quality of the place of origin is of great importance. If the producer is skilled in craftsmanship, the raw materials are appropriate, and the scale is effective, the cost may be reduced, and the price will also be lower; conversely, if the craftsmanship of the place of origin is simple, the raw materials are rare and expensive, and the price will be high. Second, the amount of less than the price has a huge impact. If you buy in large quantities, the producer may offer a discount to promote sales, and the price will be lower; if you only need a small amount, the producer may consider the cost and profit, and the price may be high. Third, the supply and demand situation in the city determines the price. If the demand is too much, the business is pursuing profit, and the price will rise; if the supply is too much, the business is destocking, or price promotion.
Looking at past market conditions, the price of 2-amino-3-methoxy-5-bromopyridine ranges from a few yuan to tens of yuan per gram. However, this is only a rough number, and it is not an exact value. To know the exact price, you need to consult the suppliers of chemical raw materials, or visit the chemical product trading platform to get the current real-time price. And the chemical market is turbulent, and the price is changing rapidly. When inquiring about the price, the current market must prevail, and there is almost no difference.