2-amino-3-iodopyridine

2-Amino-3-iodopyridine is a crucial compound in the field of organic synthesis. It has a wide range of main uses and plays a key role in many fields.
First, in the field of medicinal chemistry, this compound can be regarded as an important cornerstone for the construction of many drug molecules. Due to the unique activity of amino and iodine atoms in its structure, it can participate in a variety of chemical reactions to construct complex molecular structures with specific pharmacological activities. In the development of many new antibacterial and antiviral drugs, 2-amino-3-iodopyridine is often an indispensable starting material. By chemically modifying it, drug molecules that specifically bind to targets in organisms can be obtained, and then play a therapeutic effect on diseases.
Second, in the field of materials science, 2-amino-3-iodopyridine also has important uses. It can be used as a synthesis intermediate of functional materials for the preparation of materials with special optoelectronic properties. For example, in the development of organic Light Emitting Diode (OLED) materials, its participation in the synthesis of materials can improve the luminous efficiency and stability of OLED devices. Due to its structural properties, it can regulate the electron transport and luminous properties of materials, providing support for the development of new optoelectronic devices.
Furthermore, in the field of organic synthesis chemistry, 2-amino-3-iodopyridine is often used as a key intermediate, participating in the construction of various complex organic molecules. Its amino and iodine atoms can undergo nucleophilic substitution, coupling and other reactions respectively. Through ingenious design of reaction routes, organic compounds with special structures and functions can be synthesized, providing rich material basis and synthesis strategies for the development of organic synthetic chemistry.
In short, 2-amino-3-iodopyridine has shown important application value in the fields of medicinal chemistry, materials science and organic synthetic chemistry due to its unique chemical structure, promoting the continuous development and innovation of various fields.

2-Amino-3-iodopyridine is an important compound in organic synthesis. There are many different synthesis methods. The following are common methods:
First, 3-iodopyridine is used as the starting material. This pyridine is first reacted with a suitable protecting group to protect a specific position of the pyridine ring and avoid side reactions in subsequent reactions. The selection of the protecting group is crucial and depends on the subsequent reaction conditions and product requirements. Then, the protected 3-iodopyridine is reacted with an ammonia source. The ammonia source can be ammonia gas, ammonia water or other amino-containing reagents. This reaction usually needs to be carried out in a specific solvent, and the reaction temperature and pressure should be controlled. The choice of solvent has a great influence on the reaction, and its effect on the solubility and reactivity of the reactants needs to be considered. After this reaction, ammonia binds to the specific position of the pyridine ring to form the precursor of 2-amino-3-iodopyridine. Finally, remove the protecting group to obtain the target product 2-amino-3-iodopyridine. The deprotection step requires mild conditions to avoid affecting the structure and purity of the product.
Second, use 2-aminopyridine as the starting material. First protect the amino group of 2-aminopyridine to prevent it from being affected in the subsequent iodization reaction. Then, suitable iodizing reagents, such as iodine elemental substance, N-iodosuccinimide (NIS), etc., are selected to make the pyridine ring iodize at the 3 position. The iodization reaction conditions also need to be precisely controlled, such as reaction temperature, time and amount of iodizing reagent. After the reaction is completed, the amino protecting group is removed to obtain 2-amino-3-iodopyridine. This route focuses on the control of the selectivity of the iodization reaction to ensure that the iodization occurs at the 3 position of the pyridine ring.
Furthermore, it can be synthesized by metal-catalyzed cross-coupling reaction. A suitable halogenated pyridine (e.g. 2-halogenated-3-iodopyridine) is reacted with an amino-containing reagent in the presence of a metal catalyst (e.g. palladium catalyst) and a ligand. The activity and selectivity of metal catalysts have a significant impact on the success or failure of the reaction. Ligands can adjust the electron cloud density and steric resistance of metal catalysts, which in turn affect the activity and selectivity of the reaction. The reaction is usually carried out under basic conditions, and the choice and dosage of basic reagents also need to be considered. After this reaction, the coupling of amino groups and halogenated pyridine is achieved, resulting in 2-amino-3-iodopyridine.

2-Amino-3-iodopyridine is one of the organic compounds. It has unique physical properties and is very important in the field of organic synthesis.
Looking at its properties, it is mostly solid at room temperature, which is due to the intermolecular force. And this substance has a specific melting point. If you want to accurately determine it, you must use professional instruments to be cautious. The value of the melting point can be an important basis for identifying this compound.
As for solubility, 2-amino-3-iodopyridine may have a certain solubility in organic solvents, such as ethanol, dichloromethane, etc. However, in water, its solubility is relatively limited, which is due to the degree of matching between the polarity of the molecule and the polarity of the water molecule. The characteristics of solubility in organic solvents provide convenience for their application in organic reaction systems and can make the reaction proceed more efficiently.
Its appearance, or white to light yellow crystalline powder, the purity of color also reflects its purity. If it contains impurities, the color may change.
And its density, although the exact value needs to be strictly measured experimentally, it can be seen that its density is within a certain range compared with common organic compounds. The characteristics of density have a far-reaching impact on the material measurement and separation of chemical production and experimental operations.
The physical properties of 2-amino-3-iodopyridine are the basis for its application in many fields such as organic synthesis and drug development. Only by knowing its physical properties can we make good use of it and open up new avenues for chemical research and industrial production.

The market price of 2-amino-3-iodopyridine is difficult to determine. The price often varies due to various reasons, such as the supply and demand of the market, the cost of production, the process of production, the purity of the product, and the difference between suppliers.
Looking at the past market conditions, if the demand is prosperous and the supply is small, the price will increase; if the cost of production increases, such as the price of raw materials, labor costs, and energy consumption, the price will also rise. If the process of production is complex, or the purity is difficult to improve, the price will not be cheap.
However, according to the current market conditions, the price per gram may be between a few yuan and a few tens of yuan. This is only an approximate number, not an exact value. If you want to know the exact price, you must check the real-time dynamics of the market in detail, or consult the chemical raw material suppliers and reagent suppliers. In the industry, if the price changes, you can tell the current price to help you know the market conditions and make a purchasing decision.

2-Amino-3-iodopyridine is an organic chemical. When storing and transporting, many things need to be paid attention to.
The first priority is safety. This compound may have certain toxicity and irritation. Protective measures must be taken when contacting. Storage should be placed in a cool, dry and well-ventilated place, away from fire and heat sources to prevent danger caused by thermal decomposition. Because it is sensitive to light, it should be stored away from light. Brown bottles or opaque containers can be used.
When transporting, it is necessary to follow relevant regulations and standards, and properly pack it to ensure that it is not at risk of leakage during transportation. Packaging materials should be able to withstand certain external forces to avoid damage to the container due to collision and extrusion.
Furthermore, it should be stored and transported separately from oxidants, acids and other substances to prevent chemical reactions. Due to its active chemical properties, it is very harmful to encounter specific substances or cause violent reactions.
During storage and transportation, its packaging and storage conditions should be regularly checked to ensure that there are no abnormalities. Once package damage or other problems are detected, corresponding measures should be taken immediately.
In short, the storage and transportation of 2-amino-3-iodopyridine requires caution and strict follow of safety regulations to ensure that personnel safety and the environment are not endangered.