2-Amino-3-hydroxypyridine

2-Amino-3-hydroxypyridine has a wide range of uses. In the field of medicinal chemistry, it is a key raw material for the synthesis of many bioactive compounds. Due to the special activities of amino and hydroxyl groups in the molecule, it can participate in a variety of chemical reactions, helping chemists create drug molecules with exquisite structures and unique effects.
In the field of materials science, 2-amino-3-hydroxypyridine also has its uses. It can be introduced into the structure of polymer materials through specific reactions, giving the materials excellent properties such as better stability and unique optical properties. Due to the existence of heterocycles and active groups in the structure, the materials have potential applications in optoelectronic devices, sensors and other fields.
In the field of organic synthesis, as an important intermediate, it can use a variety of reaction paths to construct more complex organic molecular structures. Due to its special electron cloud distribution and reactivity, it can provide novel strategies and methods for organic synthesis, helping synthetic chemists to achieve efficient preparation of target products.
From this perspective, 2-amino-3-hydroxypyridine, with its unique chemical structure and reactivity, plays an important role in many key fields such as medicine, materials, and organic synthesis, and is of great significance to promote scientific research and technological development in related fields.

2-Amino-3-hydroxypyridine is also an organic compound. Its physical properties are quite important and are related to many chemical applications.
First of all, its appearance is often white to light yellow crystalline powder, like fine sand, fine texture. This form is easy to use and weigh, and is convenient for experiments and industrial production.
The melting point is about 160-164 ° C. The melting point is an inherent property of the substance. At this temperature, the solid 2-amino-3-hydroxypyridine gradually melts into a liquid state. This property can help identify the purity of the substance. If the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point decreases and the range becomes wider.
Solubility is also a key property. It is slightly soluble in water, and its solubility is slightly increased in hot water, but in general, it has limited solubility in water. However, in organic solvents such as ethanol, methanol, dichloromethane, etc., it exhibits good solubility. This property allows it to be used in organic synthesis reactions. According to the reaction requirements, suitable solvents can be selected to help it disperse and react, promote intermolecular collisions, and accelerate the reaction process.
In addition, the density of 2-amino-3-hydroxypyridine is moderate, although the exact value varies slightly with environmental conditions, it is usually stable within a certain range. Density affects its distribution and mixing in solution, which is of great significance for operations involving liquid-liquid separation or mixing.
In summary, the physical properties of 2-amino-3-hydroxypyridine, such as appearance, melting point, solubility and density, are indispensable factors in chemical research, industrial production and related application fields, helping chemists and engineers to effectively control the chemical reactions and processes in which they participate.

2-Amino-3-hydroxypyridine, which has special physical properties, has both amino and hydroxyl groups in the pyridine ring. It is weakly basic, and the guyine group can accept protons. In acidic media, the amino group is easily protonated, resulting in changes in its structure and charge distribution, which affects its chemical properties.
On solubility, because it contains polar groups, it is slightly soluble in water, and has better solubility in polar organic solvents such as ethanol and acetone. This property is conducive to its use as an intermediate in organic synthesis, and is easy to participate in reactions in various reaction systems.
Its hydroxyl groups are active and can participate in esterification and etherification reactions. In case of acid chloride or acid anhydride, hydroxyl groups can form esters. This is a common method for organic synthesis of ester compounds. And the amino group of the ortho-hydroxyl group has an effect on its activity, which makes the reaction selectivity different from that of conventional hydroxy compounds.
Amino groups are also active and can be condensed with alaldehyde and ketone compounds to form imines or Schiff bases. Such reactions are commonly used in the synthesis of nitrogen-containing heterocycles and the construction of complex organic structures.
And because of its aromatic ring, its structure is stable, endowing 2-amino-3-hydroxypyridine with certain thermal and chemical stability. However, the substituted amino and hydroxyl groups on the ring can affect the density of the ring electron cloud, causing its aromatic electrophilic substitution reaction activity and selectivity to change. < Br >
In redox reactions, 2-amino-3-hydroxypyridine can be used as an electron donor or acceptor, participating in many redox processes, and has potential applications in catalysis and battery materials.

The synthesis method of 2-amino-3-hydroxypyridine has existed in ancient times, and with the change of years, the method has also become more and more abundant.
The synthesis of ancient times depends on simple methods. First, pyridine derivatives can be used to introduce amino and hydroxyl groups through ingenious substitution. First, take a suitable pyridine compound and put it in a specific reactor to carefully prepare the reagents, create a suitable reaction environment, or apply heat energy, or catalyze, so that its molecular structure gradually changes, and the amino and hydroxyl groups are precisely positioned, eventually forming the initial shape of 2-amino-3-hydroxypyridine. However, impurities in this method often occur, and subsequent purification is time-consuming and laborious. < Br >
There is also a method of multi-step condensation based on nitrogen-containing and oxygen-containing small molecules. Several small molecules are converged in the reaction system one after another in an ingenious order. First, the nitrogen-containing small molecules meet the hydroxyl-containing precursor, and a specific catalyst is used to bridge and promote their interaction to form a key intermediate. Then through a series of transformations, or oxidation, or reduction, the molecular structure is gradually complete, and the final product is obtained. Although this path is complicated, if it is carefully controlled, the purity of the product is quite high.
Today's synthesis, with the help of technology, the method is more subtle. First, by leveraging the power of modern catalytic technology, the selection of highly active and highly selective catalysts can greatly increase the reaction rate and yield. Under mild conditions, the reaction can be carried out efficiently, the generation of side reactions can be reduced, and the purification process can be simplified. Second, the concept of green chemistry is used to optimize the reaction solvent and conditions. Replacing harmful agents in the past with environmentally friendly solvents makes the reaction more suitable for sustainable methods, which not only guarantees the efficiency of synthesis, but also protects the safety of the environment.
Looking at the synthesis method, each has its own advantages and disadvantages. The choice of method needs to be based on actual needs, and the factors of cost, yield and purity can be weighed to obtain satisfactory results.

The price of 2-amino-3-hydroxypyridine in the market is difficult to determine for various reasons. This compound has a wide range of uses and is used in medicine, pesticides, materials and other fields. Its demand situation is often different, resulting in price fluctuations.
Looking at the market situation in the past, if the quality is good and the purity is high, the price may be relatively high. And because of the difficulty of the production process, it also affects its price. If the preparation method is complicated, many steps and expensive raw materials are required, the cost will be high and the price will rise.
And the market supply and demand relationship has a huge impact on its price. If there are many people who ask for it at once, but the production is insufficient, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop.
Furthermore, the prices offered by different suppliers are also different. Those with good reputation and excellent brand, or due to strict quality control and perfect after-sales service, the price may be slightly higher.
According to the usual market prices in the past, it ranges from tens of yuan to hundreds of yuan per gram. However, this is only an approximate number. The actual price often changes due to time and place, quality, supply and demand. If you want to know the exact price, you should consult the suppliers in detail and compare their quotations before you can get a more accurate market price.