2-amino-3-hydroxy-5-bromopyridine

2-Amino-3-methoxy-5-bromopyridine is mainly used in the fields of pharmaceuticals, pesticides and materials chemistry.
In pharmaceutical chemistry, this compound is often a key intermediate for the synthesis of drugs. Due to its unique chemical structure, it can be linked to other groups through a series of reactions to construct molecules with specific pharmacological activities. For example, in the synthesis pathway of many anti-cancer drugs, 2-amino-3-methoxy-5-bromopyridine can be used as a starting material. After modification and splicing, drug molecules that can precisely act on cancer cell targets can be prepared, interfering with the proliferation and metastasis of cancer cells, and providing a powerful means for cancer treatment.
In terms of pesticide chemistry, new pesticides can be developed based on this. Its structure can endow pesticides with unique biological activities and have efficient inhibition and killing effects on specific pests or pathogens. For example, for some common fungal diseases of crops, fungicides developed based on this compound can interfere with the metabolic process of pathogens, inhibit their growth and reproduction, ensure the healthy growth of crops, and improve crop yield and quality.
In the field of material chemistry, 2-amino-3-methoxy-5-bromopyridine also has important uses. It can be used to prepare functional materials, such as organic optoelectronic materials. Due to its special electronic structure, it can affect the photoelectric properties of materials, showing potential application value in organic Light Emitting Diode (OLED), solar cells and other fields. By introducing it into the material system, it is expected to improve the performance indicators such as charge transfer efficiency and luminous efficiency of materials, and promote the development and progress of related materials science.

2-% hydroxy-3-methoxy-5-bromopyridine is a kind of organic compound. Its physical properties are quite characteristic, let me describe them in detail for you.
This substance is mostly solid at room temperature. Looking at its appearance, it is often a white or off-white crystalline powder with a fine texture, like snow falling at the beginning of winter, pure and delicate. Its melting point is about a specific range, and this melting point is an important basis for identifying and purifying the substance. Due to different purity and crystalline morphology, the melting point may vary slightly, but the approximate range is relatively stable.
When it comes to solubility, 2-hydroxy-3-methoxy-5-bromopyridine exhibits different solubility characteristics in organic solvents. In common organic solvents such as ethanol and acetone, it has a certain solubility and can slowly dissolve, and it fuses with the solvent to form a uniform solution. However, in water, its solubility is relatively low, and it can only dissolve a little, just like a shy dancer, showing only a limited posture in water.
In addition, its density is also an important physical property. Although the specific value needs to be accurately measured by instruments, the density determines its position and distribution in the mixture, which is of great significance in the separation and purification process.
Furthermore, the stability of the substance also needs attention. Under normal environmental conditions, it is relatively stable. However, in case of extreme conditions such as strong acid, strong alkali or high temperature, its structure may change, triggering a chemical reaction, like throwing boulders into a calm lake, breaking the original balance.
These physical properties have important applications in many fields such as organic synthesis and drug research and development. During synthesis, suitable reaction conditions and purification methods can be selected according to their solubility, melting point and other properties. During drug development, these properties are essential for the preparation, stability and absorption of drugs in vivo.

2-% hydroxy-3-% methoxy-5-% bromopyridine is an organic compound, which is quite useful in many fields. Its chemical properties are unique, and it can be used as a key intermediate in the field of organic synthesis. The hydroxyl group, methoxy group and bromine atoms in this compound endow it with various reactivity.
Hydroxy groups are nucleophilic and can participate in esterification reactions and react with acids to form ester compounds. Under suitable conditions, it can react with acid chloride or acid anhydride to form corresponding esters. This reaction is commonly used in the preparation of specific functional materials or pharmaceutical intermediates. The electron cloud distribution of the pyridine ring is influenced by the methoxy group, which enhances the electron cloud density of the pyridine ring and makes it more susceptible to attack by electrophilic reagents. For example, in electrophilic substitution reactions, the presence of methoxy groups can make the reaction more likely to occur, and affect the position of the substituents entering the pyridine ring, and guide the electrophilic reagents into the adjacent and para-sites of the methoxy group. The bromine atom is an active substituent and can participate in nucleophilic substitution reactions. Under the action of appropriate nucleophiles, the bromine atom can be replaced by other groups, such as amino groups and alkoxy groups, to construct compounds with more complex structures. At the same time, bromine atoms can also be used in metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc., to connect the compound with other organic fragments, expand the molecular structure, and synthesize organic materials or bioactive molecules with special functions.
In addition, these chemical properties of 2-% hydroxy-3-% methoxy-5-% bromopyridine have attracted much attention in the field of medicinal chemistry. Researchers can modify and modify its structure to develop new drugs with specific pharmacological activities based on it, providing an important material basis and research direction for pharmaceutical research and development.

2-Amino-3-furyl-5-bromopyridine is a crucial intermediate in the field of organic synthesis and is widely used in medicinal chemistry and other fields. Its synthesis methods are rich and diverse, and the following are some common ones:
###Pyridine as the starting material
1. ** Halogenation reaction foundation **: Select a suitable pyridine derivative, put it in a suitable solvent (such as dichloromethane, etc.), and carry out a bromination reaction with a brominating agent (such as N-bromosuccinimide, i.e. NBS), and introduce bromine atoms precisely at the 5-position of the pyridine ring. The reaction conditions in this step are mild, and the reaction check point can be well controlled.
2. ** Introduction of amino and furan groups **: After bromination, the product is introduced into the amino group at the 2-position and the furan group at the 3-position by nucleophilic substitution. Amination can be achieved by using a suitable amination reagent (such as an alcohol solution of ammonia, etc.) under the catalysis of a base (such as potassium carbonate, etc.), and then using furan-based halides or furan-based borates, etc., with the help of metal-catalyzed coupling reactions (such as Suzuki coupling, etc.). This process requires precise regulation of reaction conditions to improve yield and selectivity.
###Use furan derivatives as starting materials
1. ** Construction of pyridine ring precursors **: Starting with specific furan derivatives, and nitrogen-containing compounds (such as nitrile derivatives, etc.) under acidic or alkaline conditions, through cyclization reaction to construct the prototype of the pyridine ring, and pay attention to this process, cleverly reserve modifiable check points to create conditions for the subsequent introduction of bromine atoms and other groups.
2. ** Bromination and modification **: After the structure of the pyridine ring is basically formed, bromine atoms are introduced at the appropriate position (5-position) through bromination reaction, and then the 2-position amination modification is realized through appropriate reaction conditions adjustment, and the final synthesis target product 2-amino-3-furyl-5-bromopyridine. This route focuses on the rational design of furan derivatives and the careful planning of the reaction sequence to achieve efficient synthesis.
###Multi-component reaction strategy
1. ** Multi-component convergence **: Compounds containing furan fragments, nitrogen fragments and bromine fragments are selected, and multi-component reactions occur in the same reaction system under the synergistic action of metal catalysts (such as copper catalysts, etc.) and specific ligands. This method can construct complex molecular structures in one step, greatly shorten the reaction steps, and improve the synthesis efficiency.
2. ** Optimization and regulation **: However, the multi-component reaction requires fine optimization of the proportion of each component, reaction temperature, time, etc., to ensure that each reaction component effectively participates in the reaction and accurately generates the target product 2-amino-3-furanyl-5-bromopyridine, while reducing the chance of side reactions.

Nowadays, there are compounds with dihydroxy, triamino, and pentacarboxyl groups, and it is difficult to determine the price range on the market. The price is affected by many factors, and it is difficult to generalize.
As far as raw materials are concerned, if the raw materials are scarce and difficult to obtain, or the preparation process is complicated, many steps and special reagents and equipment are required, the cost will be high, and the price will also rise. And the preparation of this compound may require fine operation and precise control. A slight difference in the pool affects the yield and purity, which also increases the cost and causes price fluctuations.
Market supply and demand are also critical. If many industries have strong demand for it, such as medicine, chemical industry, etc., but the supply is limited, the price will rise according to the reason of supply and demand. On the contrary, if there is little demand or there are substitutes, the price will be lower.
Furthermore, the quality standard has a great impact. High purity and high quality, due to the difficulty of preparation, the price is far higher than that of ordinary ones.
Although it is difficult to determine the price range, it is common sense that in the fine chemical raw material market, if the quality is ordinary, the price per gram may be between tens and hundreds of yuan. If the quality is high and the purity is extremely high, it may reach thousands of yuan per gram or even higher when used in high-end pharmaceutical research and development and other fields. But this is only speculation, and the actual price must be carefully considered according to specific market conditions, quality specifications and other factors.