2-Amino-3-formylpyridine

2-Amino-3-formylpyridine is an important compound in organic chemistry. It has a wide range of uses and has important applications in many fields.
First, in the field of medicinal chemistry, this compound is often used as a key intermediate. Due to its unique structure, it can undergo a series of chemical reactions to construct drug molecules with specific pharmacological activities. By modifying and modifying its structure, chemists can design and synthesize drugs for different disease targets, such as anti-cancer, anti-inflammatory, antibacterial and other drugs. Taking the development of anti-cancer drugs as an example, researchers can use 2-amino-3-formylpyridine as a starting material to introduce various active groups and synthesize new anti-cancer compounds through multi-step reactions, providing new drug options for the treatment of cancer.
Second, in the field of materials science, 2-amino-3-formylpyridine also has important functions. Because it can coordinate with metal ions, it can be used to prepare metal-organic framework materials (MOFs). These materials have excellent characteristics such as high specific surface area and regular pore structure, and show great potential in gas adsorption, separation, catalysis and other fields. For example, in the field of gas adsorption, MOFs materials with specific structures can efficiently adsorb gases such as carbon dioxide, which contributes to environmental protection and resource recovery.
Furthermore, in the field of organic synthesis chemistry, 2-amino-3-formylpyridine is often used as a reaction substrate and participates in various organic reactions, such as nucleophilic substitution reactions, cyclization reactions, etc. Through these reactions, complex organic compounds can be constructed, methods and strategies of organic synthesis can be expanded, and new ideas and approaches can be provided for the development of organic synthesis chemistry.

2-Amino-3-formylpyridine is one of the organic compounds. Its physical properties are quite important and are related to many chemical applications.
First of all, its appearance is mostly solid at room temperature and pressure, but it is not absolute, or slightly different due to purity and preparation conditions. Looking at its color, it is often white to light yellow powder, just like fine sand, fine and uniform.
As for the melting point, the value of the melting point of this substance is within a certain range. This value is a key indicator when identifying and purifying. The determination of the melting point of the cap can verify its purity. The melting point of the pure one is relatively constant. If it contains impurities, the melting point changes and the melting range increases.
Solubility is also an important physical property. 2-Amino-3-formylpyridine exhibits specific solubility properties in organic solvents. Common organic solvents such as ethanol and dichloromethane are soluble, but their solubility varies. In ethanol, with the increase of temperature, the solubility increases gradually. This is because the change of temperature affects the intermolecular force, making it easier for the solute to interact with the solvent molecules. In water, its solubility is relatively limited. Although there are polar groups in the molecular structure of the cap, the overall hydrophobic part also exists, so it is difficult to dissolve in water.
In addition, the density of this substance is also a specific value. Although it is not a primary concern in general experiments, it cannot be ignored in some situations involving accurate measurement and construction of reaction systems. The determination of density can help chemists accurately control the amount of reaction materials and ensure that the reaction proceeds as expected.
In short, the physical properties of 2-amino-3-formylpyridine, such as appearance, melting point, solubility, density, etc., are the cornerstones of chemical research and application. Scholars should investigate in detail to make good use of this substance.

To prepare 2-amino-3-formylpyridine, the following method can be used.
2-aminopyridine is often used as the starting material. First, the 3-position of 2-aminopyridine is formylated. The commonly used method is the Vilsmeier-Haack reaction. In this reaction, N, N-dimethylformamide (DMF) reacts with phosphorus oxychloride (POCl 🥰) to form an active Vilsmeier reagent. This reagent can be electrophilically substituted with the 3-position of 2-aminopyridine to introduce formyl groups.
For specific operation, first add an appropriate amount of DMF to the reaction vessel containing POCl < unk > at low temperature, and stir for a few times to fully react to generate Vilsmeier reagent. Then, slowly add 2-aminopyridine to it, heat up to an appropriate temperature, usually 50-80 ° C, and react for several hours. After the reaction is completed, pour the reaction solution into ice water, neutralize it with alkali solution to neutral or weakly alkaline, and solid precipitation can be seen at this time. Suction filtration, polyester it with cold water to obtain a crude product. After recrystallization, using solvents such as ethanol or ethyl acetate, pure 2-amino-3-formylpyridine can be obtained.
There are other methods, such as using 2-amino-3-methylpyridine as raw material, first oxidizing the methyl group to the aldehyde group. A mild oxidizing agent can be used, such as manganese dioxide (MnO _ 2) combined with sulfuric acid, or SeO _ 2, etc., in a suitable solvent, such as glacial acetic acid, 2-amino-3-formylpyridine can also be obtained. However, caution should be taken to control the reaction conditions to obtain satisfactory yield and purity.

2-Amino-3-formylpyridine is an organic compound. When storing and transporting, many matters need careful attention.
First, the storage temperature is very important. This compound is sensitive to temperature and should be stored in a cool place. Generally, the temperature should not exceed 25 ° C. If the temperature is too high, it may cause chemical reactions such as decomposition and polymerization, which will damage the quality. For example, if it is hot in summer, if the warehouse does not have good temperature control, the compound may deteriorate.
Second, the humidity should not be ignored. It should be stored in a dry environment to prevent moisture. Because of its certain hygroscopicity, the purity and stability may be affected after moisture absorption. For example, in the rainy season in the south, the air humidity is high. If there are no moisture-proof measures, it is easy to increase the water content of the compound.
Third, pay attention to the storage container. A well-sealed container should be used to avoid contact with the air. 2-Amino-3-formylpyridine may react with oxygen, carbon dioxide and other ingredients in the air. When storing in a glass bottle, the cap must be tightened.
Fourth, during transportation, ensure that the packaging is in good condition. Due to vibration, collision or damage to the packaging, the compound leaks. If long-distance transportation, when the road conditions are not good, it is necessary to do a good job of buffering protection.
Fifth, this compound may have certain toxicity and irritation, and storage and transportation personnel should take good protection. Such as wearing gloves, masks, goggles, etc. to prevent contact and inhalation.
In short, 2-amino-3-formylpyridine has strict requirements on temperature and humidity, containers, packaging and personnel protection during storage and transportation, so as to ensure its quality and safety.

2-Amino-3-formylpyridine, the price on the market is geometric, it is difficult to determine. The price varies from reason to reason, such as the quality of the quality, the amount of purchase, and the supply and demand of the market, all of which can affect the price.
Looking at the past, the price of chemical raw materials often fluctuated. Those who are of high quality may have a slightly higher price; those who buy in large quantities may have a discount. And changes in market supply and demand are also the key to the price. If there are many in demand and few in supply, the price will rise; conversely, if the supply exceeds the demand, the price will decline. < Br >
If you want to know the exact price, you should consult the merchant of chemical materials, or visit it on the platform of chemical trading. Where you can get the current market conditions, the price is credible. Or you can refer to the price of past transactions, but you can't rely entirely on it. The market conditions are fickle, and the price changes over time.