2-Amino-3-Fluoro-4-methylpyridine

2-Amino-3-fluoro-4-methylpyridine is one of the organic compounds. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate for the synthesis of many drugs. Due to its special chemical structure, it can participate in a variety of chemical reactions and help to construct molecular structures with specific biological activities, which is expected to develop new drugs for the treatment of various diseases.
In the field of pesticide chemistry, this compound also plays an important role. It can be used as a raw material to prepare highly efficient and low-toxic pesticides. With its unique chemical properties, pesticide products that have a strong targeted killing effect on pests and have little impact on the environment and non-target organisms can be designed and synthesized to meet the needs of modern agriculture for green and environmentally friendly pesticides.
In addition, in the field of materials science, 2-amino-3-fluoro-4-methylpyridine may play a role. It can be used as a synthetic component of functional materials, giving materials such as special optical and electrical properties, and has potential value in the research and development of new organic materials. In the process of scientific research and exploration, it is also an important object of organic synthetic chemistry research. Chemists can explore various reactions and expand the methodology of organic synthesis, providing new ideas and methods for the synthesis of more complex organic compounds.

2-Amino-3-fluoro-4-methylpyridine, this substance is white to pale yellow crystalline powder, which is fine and uniform in appearance. Its melting point is about a specific range, due to the characteristics of intermolecular forces and structures. Under normal temperature and pressure, the properties are quite stable, but under extreme temperature and pressure conditions, there may be subtle changes.
When it comes to solubility, it has a certain solubility in organic solvents such as ethanol and acetone. Due to the fact that organic substances are similar and compatible, their molecular structure is compatible with organic solvents. However, in water, the solubility is relatively limited, because the polarity of water and the polarity of the substance are not perfectly matched.
2-Amino-3-fluoro-4-methylpyridine has a certain chemical activity, and the amino group, fluorine atom and methyl group give it unique reactivity. Amino groups can participate in many nucleophilic reactions. Fluorine atoms affect the distribution of molecular electron clouds due to their electronegativity, while methyl groups contribute to steric hindrance and electronic effects. The interaction of these three makes the substance capable of involving various organic reactions and has a wide range of uses in the field of organic synthesis.

To prepare 2-amino-3-fluoro-4-methylpyridine, there are many methods, and the following are common synthesis methods.
First, pyridine derivatives containing suitable substituents are used as starting materials. You can take 4-methylpyridine first, and introduce nitro at a suitable position through nitration reaction. In this step, you need to choose a suitable nitrification reagent and reaction conditions, such as the mixed acid system of nitric acid and sulfuric acid, control the temperature, the proportion of reactants and other factors, so that the nitro group precisely falls at the desired check point. Then the nitro group is reduced to an amino group, and common reducing agents such as hydrogen (using palladium carbon as a catalyst), iron/hydrochloric acid system, etc. As for the introduction of fluorine atoms, fluorine atoms can be introduced into the pyridine ring at a suitable position by means of a nucleophilic substitution reaction. This process requires the selection of the leaving group and ensures that the reaction environment is conducive to the smooth progress of nucleophilic substitution.
Second, it can also be started from the perspective of constructing a pyridine ring. For example, a suitable nitrogen-containing, fluorine-containing, and methyl-containing small molecule compound is used as raw material to construct a pyridine ring through a multi-step reaction. For example, a β-ketone ester compound, a fluorine-containing amine compound, etc. are used in the presence of a suitable base and catalyst to form a pyridine ring through cyclization, and the desired amino group, fluorine atom, and methyl group are introduced at the same time. In the reaction process, it is crucial to control the reaction conditions, such as the choice of temperature and solvent, and the selectivity and yield of products vary significantly under different conditions.
Third, the coupling reaction catalyzed by transition metals can also be used. First prepare pyridine intermediates containing specific functional groups, and then couple with reagents containing fluorine, amino or methyl groups catalyzed by transition metals (such as palladium, nickel, etc.). Reactions such as Suzuki coupling and Heck coupling can effectively connect different fragments to achieve the synthesis of the target product. In this way, the choice of ligands, the amount and activity of metal catalysts have a great impact on the success or failure of the reaction. In the process of
synthesis, each step of the reaction often requires separation and purification operations, such as extraction, distillation, column chromatography, etc., to obtain high-purity products. Each step requires fine operation and strict control to achieve satisfactory yield and purity.

I look at this question, and I am inquiring about the price range of 2-amino-3-fluoro-4-methylpyridine on the market. However, the price of this chemical often changes for many reasons, and it is difficult to determine its fixed number.
First, the source of supply has a great impact. If the supply is sufficient and there are many products, the price may be more affordable; if the supply is scarce, the supply is limited, and the price will rise. And the price of goods from different origins varies depending on the process and quality.
Second, the quantity of purchase is related to the price. If the purchase volume is huge, the merchant may give it a discount in order to promote the transaction, and the price may be reduced; if the purchase volume is only a small case, the merchant may maintain a higher price considering the cost.
Third, the supply and demand situation of the market is also the key. If there are many demands, but there is insufficient supply, the price will go up; if there are few demands, the supply will exceed the demand, and the price will tend to decline.
Fourth, the quality specifications are different, and the price is also different. For high purity and meeting special standards, the price will be higher than that of ordinary specifications.
According to past market conditions, the price of this chemical may range from a few yuan to tens of yuan per gram. However, this is only a rough estimate, and market conditions are constantly changing. To know the exact price, you need to consult chemical raw material suppliers, chemical trading platforms, etc., and they can only be confirmed based on the current situation.

2-Amino-3-fluoro-4-methylpyridine is one of the organic compounds. Its storage conditions are related to the stability and quality of this substance, which cannot be ignored.
When storing this substance, the first environment is drying. The cover moisture can easily cause the compound to undergo reactions such as hydrolysis, which damages its structure and properties. Therefore, it should be placed in a dry place, such as a sealed container with a desiccant, to prevent the intrusion of moisture.
The temperature is also the key. It should be stored in a cool place to avoid high temperature. Under high temperature, the compound or biodegradation, polymerization, etc. change, causing it to deteriorate. Generally speaking, a low temperature environment of 2-8 ° C is preferred, which can effectively slow down its chemical reaction rate and maintain its stability.
Furthermore, light can also affect its quality. Light can initiate photochemical reactions, resulting in changes in the structure of the compound. Therefore, when storing, it should be placed in a container protected from light, such as a brown bottle, to block light exposure.
In addition, the storage place should be away from fire sources, oxidants, etc. If this compound encounters an open flame, hot topic or oxidant, it may burn or explode. And it needs to be placed separately from other chemicals to prevent mutual reaction.
To properly store 2-amino-3-fluoro-4-methylpyridine, it is necessary to create a dry, cool, dark environment, and avoid sources of ignition and incompatible substances, so as to ensure its quality and safety.