2-Amino-3-chloro-5-nitropyridine

2-Amino-3-chloro-5-nitropyridine is a crucial compound in the field of organic synthesis. Its main use is the key intermediate of drug synthesis. When creating new antibacterial and antiviral drugs, this compound can be ingeniously reacted and integrated into the molecular structure of the drug, giving the drug specific biological activity and pharmacological properties.
Furthermore, in the field of pesticide synthesis, it is also highly valued. With its unique chemical structure, many efficient and low-toxic pesticide varieties can be derived, helping crops resist the attack of pests and diseases, and improving the yield and quality of agricultural products.
In addition, in the field of materials science, 2-amino-3-chloro-5-nitropyridine has also emerged. It can be used to prepare organic materials with special photoelectric properties, such as in frontier fields such as organic Light Emitting Diodes (OLEDs) and solar cells, and contribute to the performance optimization and innovative development of related materials. Due to the ingenious combination of amino groups, chlorine atoms and nitro groups in its chemical structure, this compound has unique electronic properties and reactivity, so it has shown broad application prospects in many of these fields.

The synthesis method of 2-amino-3-chloro-5-nitropyridine, through the ages, chemists have developed several ways.
First, pyridine is used as the initial material. First, pyridine meets with nitrifying reagents under specific conditions, such as the mixed acid of concentrated nitric acid and concentrated sulfuric acid. After nitrification, the nitro group is introduced into the pyridine ring to obtain the nitro-containing pyridine derivative. Then, the derivative meets with chlorinated reagents, such as phosphorus oxychloride, and undergoes a chlorination reaction, adding chlorine atoms at suitable positions. Finally, it is reacted with amination reagents, such as ammonia gas or amine compounds, under appropriate conditions to introduce amino groups, and finally obtain 2-amino-3-chloro-5-nitropyridine.
Second, other nitrogen-containing heterocyclic compounds are used as starting materials. If a certain type of pyrrole derivative is selected, a series of cyclization and substitution reactions are used. First, the pyridine ring structure is constructed through cyclization reaction. This process requires a specific catalyst and reaction environment. Then, nitrification, chlorination and amination reactions are carried out in sequence. The conditions of each step of the reaction need to be precisely controlled, such as temperature, reaction time, and the proportion of reactants. The target product can also be obtained.
Third, palladium-catalyzed cross-coupling reaction strategy can also be used. Select suitable halogenated pyridine derivatives, and reagents containing amino groups, nitro groups and chlorine atoms, in the presence of palladium catalysts and ligands, to achieve the formation of carbon-heteroatom bonds, and through careful regulation of the reaction, the molecular structure of 2-amino-3-chloro-5-nitropyridine is gradually combined. This method has high requirements on reaction conditions and catalysts, but it can effectively improve the selectivity and yield of the product.

2-Amino-3-chloro-5-nitropyridine is one of the organic compounds. Its physical properties are unique, and it is related to the properties of this substance, its melting point, and its solubility.
Looking at its properties, under normal temperature and pressure, 2-amino-3-chloro-5-nitropyridine is mostly in a solid state. Its color may be a white-like to light yellow powder. The characterization of this color can help identify this substance at the time of preliminary observation.
As for the melting point, this substance has a specific melting point value, but the exact value needs to be determined by professional. Melting point, the critical temperature at which a substance changes from solid to liquid. For 2-amino-3-chloro-5-nitropyridine, the determination of the melting point helps to confirm its purity and identify the compound. If impurities are mixed, the melting point may be deviated, or the melting range may be widened.
In terms of solubility, 2-amino-3-chloro-5-nitropyridine behaves differently in different solvents. In common organic solvents, such as methanol, ethanol, dichloromethane, etc., its solubility may vary. In general, in polar organic solvents, due to the molecular structure of both amino polar groups, chlorine, nitro, etc., or exhibit a certain solubility. However, in water, due to the relatively high degree of non-polarity of the whole molecule, the solubility may be poor.
In addition, the density of the compound is also one end of its physical properties. Although the exact density value needs to be carefully measured, it can be inferred that its density is comparable to that of common organic solid compounds. This property is of great significance in many application scenarios involving the relationship between mass and volume, such as the measurement of substances, separation, and the design of reaction systems. The physical properties of 2-amino-3-chloro-5-nitropyridine, such as its properties, melting point, solubility, and density, are crucial in chemical synthesis, drug discovery, and other fields, providing a foundation for its preparation, separation, identification, and application.

2-Amino-3-chloro-5-nitropyridine, the chemical properties of this substance are unique and complex. It is basic, due to the existence of amino groups, the nitrogen atom in the amino group has lone pairs of electrons, which can be combined with protons, so it is alkaline.
In nucleophilic substitution reactions, this substance is quite active. Chlorine atoms are attached to the pyridine ring, and the pyridine ring has an electron-absorbing effect, which reduces the electron cloud density of chlorine atoms and makes them vulnerable to attack by nucleophilic reagents. Nucleophilic reagents can replace chlorine atoms to generate new compounds.
And because of its nitro-containing group, nitro is a strong electron-absorbing group, causing the electron cloud density of the pyridine ring to decrease significantly, which increases the difficulty of electrophilic substitution reaction on the ring. However, under certain conditions, electrophilic substitution can still occur, but the reaction check point is different from that of ordinary pyridine, mostly in the neighbor and counterposition of the amino group.
Furthermore, 2-amino-3-chloro-5-nitropyridine may participate in the redox reaction. Nitro can be reduced to other groups such as amino groups under the action of appropriate reducing agents, and this process involves electron transfer and rearrangement of chemical bonds. It may also react with a variety of metal ions, because the amino group can be used as a ligand, and the lone pair electron of the nitrogen atom coordinates with the metal ion to form a stable complex, which may have potential applications in the fields of catalysis and materials science. In conclusion, the chemical properties of 2-amino-3-chloro-5-nitropyridine are rich and diverse, and are of great significance in organic synthesis and related fields.

2-Amino-3-chloro-5-nitropyridine is in the market, and its price range is difficult to determine. The price of this compound often varies due to various factors. First, the amount is the main factor. If the purchase quantity is large, the price may be cheaper; if the purchase quantity is small, the price may be higher. Second, the source also has an impact. Different producers have different processes, quality or different, and the price is also different. Third, the supply and demand situation of the market also makes the price fluctuate. If supply exceeds demand, the price will decline; if supply exceeds demand, the price may rise.
Looking at the market situation in the past, the price of 2-amino-3-chloro-5-nitropyridine is between a few and tens of yuan per gram. However, this is only a rough estimate, and the actual price depends on the current market conditions, the supplier sought by the buyer, and various trading conditions. To know the exact price, it is recommended to consult the chemical raw material supplier, or check the latest quotation of the relevant chemical product trading platform, to get a close price.